SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 6 THR A 272
PHE A 402
PHE A 257
GLY A 404
 None
 1.07A 1icuA-5e5bA:
undetectable
1icuB-5e5bA:
undetectable		 1icuA-5e5bA:
20.75
1icuB-5e5bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 6 PHE A 257
GLY A 404
THR A 272
PHE A 402
 None
 1.10A 1icuA-5e5bA:
undetectable
1icuB-5e5bA:
undetectable		 1icuA-5e5bA:
20.75
1icuB-5e5bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 PHE A 257
GLY A 404
THR A 272
PHE A 402
 None
 1.00A 1icuC-5e5bA:
undetectable
1icuD-5e5bA:
undetectable		 1icuC-5e5bA:
20.75
1icuD-5e5bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 PHE A 257
GLY A 404
THR A 272
PHE A 402
 None
 1.12A 1icvA-5e5bA:
undetectable
1icvB-5e5bA:
undetectable		 1icvA-5e5bA:
20.75
1icvB-5e5bA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 6 THR A 272
PHE A 402
PHE A 257
GLY A 404
 None
 1.06A 1kqbA-5e5bA:
undetectable
1kqbB-5e5bA:
undetectable		 1kqbA-5e5bA:
20.27
1kqbB-5e5bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 6 THR A 272
PHE A 402
PHE A 257
GLY A 404
 None
 1.02A 1kqbC-5e5bA:
undetectable
1kqbD-5e5bA:
undetectable		 1kqbC-5e5bA:
20.27
1kqbD-5e5bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 6 PHE A 257
GLY A 404
THR A 272
PHE A 402
 None
 1.05A 1kqbC-5e5bA:
undetectable
1kqbD-5e5bA:
undetectable		 1kqbC-5e5bA:
20.27
1kqbD-5e5bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 SER A  37
SER A  49
VAL A 136
PHE A 137
 None
 1.22A 1oipA-5e5bA:
undetectable		 1oipA-5e5bA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		5 / 11 ALA A 186
THR A 406
SER A 284
TYR A 243
SER A 191
 None
 1.28A 2xfsB-5e5bA:
undetectable		 2xfsB-5e5bA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		5 / 12 ILE A 247
LEU A 217
ILE A 205
MET A 266
VAL A 292
 None
 0.96A 2ygnA-5e5bA:
undetectable		 2ygnA-5e5bA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 GLU A 204
SER A 220
VAL A 221
 None
 0.81A 3eeoA-5e5bA:
undetectable		 3eeoA-5e5bA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		5 / 12 PHE A 356
ASN A 367
PHE A 257
ILE A 379
GLY A 351
 None
 1.13A 3ps9A-5e5bA:
undetectable		 3ps9A-5e5bA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 LEU A 381
GLY A 382
MET A 330
PHE A 304
 None
 1.30A 3uq6B-5e5bA:
undetectable		 3uq6B-5e5bA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 4 LEU A 381
GLY A 382
MET A 330
PHE A 304
 None
 1.28A 3vaqB-5e5bA:
undetectable		 3vaqB-5e5bA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		3 / 3 ASP A  63
GLU A 145
GLY A 144
 None
 0.58A 3w9tA-5e5bA:
undetectable		 3w9tA-5e5bA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 THR A 171
ILE A 172
GLU A 358
PHE A 137
 None
 1.44A 4ac9C-5e5bA:
undetectable		 4ac9C-5e5bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 THR A 171
ILE A 172
GLU A 358
PHE A 137
 None
 1.39A 4acaC-5e5bA:
undetectable		 4acaC-5e5bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		4 / 5 THR A 171
ILE A 172
GLU A 358
PHE A 137
 None
 1.40A 4acbC-5e5bA:
undetectable		 4acbC-5e5bA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		5 / 9 VAL A  36
PHE A 137
ILE A 164
TRP A  55
LEU A  17
 None
 1.34A 5e4dA-5e5bA:
undetectable		 5e4dA-5e5bA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_B_6T0B913_0
(TOLL-LIKE RECEPTOR 7)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		5 / 9 VAL A 428
THR A 419
ASP A 405
LEU A 286
ILE A 403
 None
 1.26A 5zsfA-5e5bA:
undetectable
5zsfB-5e5bA:
undetectable		 5zsfA-5e5bA:
13.15
5zsfB-5e5bA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5e5b FACT COMPLEX SUBUNIT
SPT16
(Homo
sapiens) 		5 / 9 LEU A 418
THR A 419
SER A 378
GLY A 404
ILE A 379
 None
 1.34A 6ebpA-5e5bA:
undetectable		 6ebpA-5e5bA:
10.50