SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L2I_B_CCSB417_0 (ESTROGEN RECEPTOR)	5e5m	CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 (Mus musculus)	4 / 6	PRO A 20 PHE A 19 GLN A 5 VAL A 8	None	0.99A	1l2iB-5e5mA: undetectable	1l2iB-5e5mA: 17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	5e5m	CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 MOUSE ANTI CTLA-4 NANOBODY (Mus musculus)	5 / 12	GLY B 101 VAL B 4 LEU A 96 ALA B 35 SER B 53	None	1.27A	3d91B-5e5mB: undetectable	3d91B-5e5mB: 15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNW_A_RTZA602_1 (CYTOCHROME P450 2D6)	5e5m	CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 (Mus musculus)	5 / 12	GLY A 81 LEU A 82 GLN A 80 SER A 12 VAL A 114	GOL A 201 (-4.5A) GOL A 201 (-4.7A) None None None	1.22A	4wnwA-5e5mA: undetectable	4wnwA-5e5mA: 12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UL4_A_SAMA803_0 (OXSB PROTEIN)	5e5m	CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 (Mus musculus)	5 / 12	PHE A 52 GLY A 68 GLY A 59 GLU A 46 LEU A 37	None	1.09A	5ul4A-5e5mA: undetectable	5ul4A-5e5mA: 9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X66_F_MTXF402_1 (THYMIDYLATE SYNTHASE)	5e5m	CYTOTOXIC T-LYMPHOCYTE PROTEIN 4 (Mus musculus)	5 / 12	LEU A 82 GLY A 81 PHE A 65 ALA A 84 VAL A 85	GOL A 201 (-4.7A) GOL A 201 (-4.5A) GOL A 201 ( 4.6A) None None	0.89A	5x66F-5e5mA: undetectable	5x66F-5e5mA: 20.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1L2I_B_CCSB417_0","ESTROGEN RECEPTOR","5e5m","CYTOTOXIC T-LYMPHOCYTE PROTEIN 4","Mus musculus",4,"PRO A  20;PHE A  19;GLN A   5;VAL A   8","None","0.99A","1l2iB-5e5mA:undetectable","1l2iB-5e5mA:17.76"],["3D91_B_REMB350_1","RENIN","5e5m","CYTOTOXIC T-LYMPHOCYTE PROTEIN 4;MOUSE ANTI CTLA-4 NANOBODY","Mus musculus",5,"GLY B 101;VAL B   4;LEU A  96;ALA B  35;SER B  53","None","1.27A","3d91B-5e5mB:undetectable","3d91B-5e5mB:15.74"],["4WNW_A_RTZA602_1","CYTOCHROME P450 2D6","5e5m","CYTOTOXIC T-LYMPHOCYTE PROTEIN 4","Mus musculus",5,"GLY A  81;LEU A  82;GLN A  80;SER A  12;VAL A 114","GOL A 201 (-4.5A);GOL A 201 (-4.7A);None;None;None","1.22A","4wnwA-5e5mA:undetectable","4wnwA-5e5mA:12.66"],["5UL4_A_SAMA803_0","OXSB PROTEIN","5e5m","CYTOTOXIC T-LYMPHOCYTE PROTEIN 4","Mus musculus",5,"PHE A  52;GLY A  68;GLY A  59;GLU A  46;LEU A  37","None","1.09A","5ul4A-5e5mA:undetectable","5ul4A-5e5mA:9.26"],["5X66_F_MTXF402_1","THYMIDYLATE SYNTHASE","5e5m","CYTOTOXIC T-LYMPHOCYTE PROTEIN 4","Mus musculus",5,"LEU A  82;GLY A  81;PHE A  65;ALA A  84;VAL A  85","GOL A 201 (-4.7A);GOL A 201 (-4.5A);GOL A 201 ( 4.6A);None;None","0.89A","5x66F-5e5mA:undetectable","5x66F-5e5mA:20.07"]]