SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e66'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		5 / 12 SER A 281
PHE A 138
TYR A 139
LEU A 154
TYR A 103
 None
 1.48A 1p33A-5e66A:
2.6		 1p33A-5e66A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		4 / 6 GLY A 372
GLY A  42
GLN A 316
PHE A  80
 None
 0.98A 2qx6A-5e66A:
undetectable
2qx6B-5e66A:
undetectable		 2qx6A-5e66A:
18.89
2qx6B-5e66A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		4 / 5 VAL A 116
PHE A 138
ARG A  58
ARG A 327
 CAC  A 501 (-4.7A)
None
None
None
 1.49A 3bjwE-5e66A:
undetectable		 3bjwE-5e66A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		5 / 12 ALA A  43
GLY A  42
SER A 369
PHE A 344
TYR A 113
 None
 1.30A 3bxoA-5e66A:
undetectable		 3bxoA-5e66A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		5 / 12 ALA A  43
GLY A  42
SER A 369
PHE A 344
TYR A 113
 None
 1.33A 3bxoB-5e66A:
undetectable		 3bxoB-5e66A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		4 / 5 TYR A 101
ARG A  81
ILE A  52
THR A 150
 None
 0.94A 3dgqA-5e66A:
undetectable		 3dgqA-5e66A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		5 / 9 ASP A 261
GLY A 258
ILE A 257
PRO A 301
VAL A 300
 None
 1.17A 3ekyB-5e66A:
undetectable		 3ekyB-5e66A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		3 / 3 TRP A 179
VAL A 300
TRP A 185
 None
None
5KQ  A 513 ( 4.8A)
 1.50A 3zq8A-5e66A:
undetectable
3zq8B-5e66A:
undetectable		 3zq8A-5e66A:
4.43
3zq8B-5e66A:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		4 / 5 VAL A 111
LEU A 371
VAL A  76
PHE A  80
 None
 0.94A 4lb0B-5e66A:
undetectable		 4lb0B-5e66A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5e66 HEMAGGLUTININ-ESTERA
SE
(Influenza
D
virus) 		4 / 7 ILE A 257
GLY A 258
PHE A  93
PHE A 138
 None
 1.06A 5hieA-5e66A:
undetectable		 5hieA-5e66A:
19.06