SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		5 / 12 HIS A  11
ALA A  22
VAL A   9
ALA A 160
LEU A 166
 None
 1.17A 1udtA-5e68A:
undetectable		 1udtA-5e68A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		5 / 12 MET A  14
ALA A  16
ASN A  44
ILE A 142
ILE A  53
 None
None
None
None
PAV  A 202 ( 4.2A)
 1.29A 2bjfA-5e68A:
undetectable		 2bjfA-5e68A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.74A 2dysA-5e68A:
undetectable		 2dysA-5e68A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_N_CUN601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.74A 2dysN-5e68A:
undetectable		 2dysN-5e68A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.74A 2eimN-5e68A:
undetectable		 2eimN-5e68A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_A_CUA517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.72A 2einA-5e68A:
undetectable		 2einA-5e68A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.73A 2einN-5e68A:
undetectable		 2einN-5e68A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		5 / 12 HIS A  11
ALA A  22
VAL A   9
ALA A 160
LEU A 166
 None
 1.08A 2h42B-5e68A:
undetectable		 2h42B-5e68A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		5 / 10 GLU A  57
PHE A  87
VAL A  19
ALA A  18
PHE A  40
 None
 1.30A 3a3yA-5e68A:
undetectable		 3a3yA-5e68A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S39_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.77A 3s39A-5e68A:
undetectable		 3s39A-5e68A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3B_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.78A 3s3bA-5e68A:
undetectable		 3s3bA-5e68A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3C_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.78A 3s3cA-5e68A:
undetectable		 3s3cA-5e68A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3D_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		3 / 3 HIS A  58
HIS A 134
HIS A  54
 ZN  A 201 (-3.3A)
ZN  A 201 ( 4.8A)
ZN  A 201 (-3.2A)
 0.77A 3s3dA-5e68A:
undetectable		 3s3dA-5e68A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		5 / 12 VAL A  73
PHE A  36
LEU A  38
LYS A 105
ALA A 107
 None
 1.03A 4rtbA-5e68A:
undetectable		 4rtbA-5e68A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		5 / 12 GLY A  52
HIS A  54
PHE A  87
ILE A 146
ALA A 143
 None
ZN  A 201 (-3.2A)
None
None
None
 0.96A 5n4iA-5e68A:
undetectable		 5n4iA-5e68A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5e68 S-RIBOSYLHOMOCYSTEIN
E LYASE
(Salmonella
enterica) 		4 / 8 ALA A 106
ILE A 146
ALA A 143
LEU A 147
 None
 0.75A 5te8B-5e68A:
undetectable		 5te8B-5e68A:
16.77