SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 8 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.79A 1v54C-5e6gA:
3.6
1v54J-5e6gA:
undetectable		 1v54C-5e6gA:
19.51
1v54J-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 8 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.79A 1v54P-5e6gA:
3.6
1v54W-5e6gA:
undetectable		 1v54P-5e6gA:
19.51
1v54W-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 8 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.80A 2dyrC-5e6gA:
3.6
2dyrJ-5e6gA:
undetectable		 2dyrC-5e6gA:
19.51
2dyrJ-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 8 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.81A 2dyrP-5e6gA:
3.6
2dyrW-5e6gA:
undetectable		 2dyrP-5e6gA:
19.51
2dyrW-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 6 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.83A 3abkP-5e6gA:
3.6
3abkW-5e6gA:
undetectable		 3abkP-5e6gA:
19.51
3abkW-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 8 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.79A 3ag4C-5e6gA:
3.6
3ag4J-5e6gA:
undetectable		 3ag4C-5e6gA:
19.51
3ag4J-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 7 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.82A 3ag4P-5e6gA:
3.6
3ag4W-5e6gA:
undetectable		 3ag4P-5e6gA:
19.51
3ag4W-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 6 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.81A 3wg7C-5e6gA:
3.6
3wg7J-5e6gA:
undetectable		 3wg7C-5e6gA:
19.51
3wg7J-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 6 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.90A 3wg7P-5e6gA:
3.6
3wg7W-5e6gA:
undetectable		 3wg7P-5e6gA:
19.51
3wg7W-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 7 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.82A 3x2qC-5e6gA:
3.6
3x2qJ-5e6gA:
undetectable		 3x2qC-5e6gA:
19.51
3x2qJ-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 7 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.84A 3x2qP-5e6gA:
3.6
3x2qW-5e6gA:
undetectable		 3x2qP-5e6gA:
19.51
3x2qW-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		5 / 12 ALA A  65
LEU A  46
ILE A  15
LEU A  16
LEU A 106
 None
 1.03A 4j24D-5e6gA:
undetectable		 4j24D-5e6gA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		6 / 12 LEU A  88
LEU A  12
ILE A   8
ILE A  58
VAL A  62
PHE A  81
 None
 1.34A 4y0rA-5e6gA:
undetectable		 4y0rA-5e6gA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 7 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.92A 5b1bP-5e6gA:
3.6
5b1bW-5e6gA:
undetectable		 5b1bP-5e6gA:
19.51
5b1bW-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		5 / 12 GLN A  18
PRO A 110
ALA A 111
LEU A  88
ILE A   8
 None
 1.03A 5hv1A-5e6gA:
undetectable		 5hv1A-5e6gA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 5 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.81A 5x19C-5e6gA:
3.6
5x19J-5e6gA:
undetectable		 5x19C-5e6gA:
19.51
5x19J-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 7 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.90A 5zcoC-5e6gA:
3.6
5zcoJ-5e6gA:
undetectable		 5zcoC-5e6gA:
19.51
5zcoJ-5e6gA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6g DE NOVO DESIGNED
PROTEIN CA01
(synthetic
construct) 		4 / 7 LEU A  88
PHE A 102
LEU A 106
PHE A  81
 None
 0.89A 5zcqC-5e6gA:
3.6
5zcqJ-5e6gA:
undetectable		 5zcqC-5e6gA:
19.51
5zcqJ-5e6gA:
16.81