SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 SER A 197
GLY A 343
HIS A 344
ILE A 342
 None
 0.94A 1gtnF-5e6kA:
undetectable
1gtnG-5e6kA:
undetectable		 1gtnF-5e6kA:
9.30
1gtnG-5e6kA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ALA A 440
ILE A 576
LEU A 578
PRO A 579
TYR A 568
 None
 1.13A 1jolB-5e6kA:
undetectable		 1jolB-5e6kA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ALA A 440
ILE A 576
LEU A 578
PRO A 579
TYR A 568
 None
 1.09A 1rx8A-5e6kA:
undetectable		 1rx8A-5e6kA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 ALA A 440
LEU A 499
LEU A 578
PRO A 579
TYR A 568
 None
 1.06A 1rx8A-5e6kA:
undetectable		 1rx8A-5e6kA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 6 TYR A 199
SER A 169
ALA A 347
SER A 346
 None
 1.06A 1yvpB-5e6kA:
undetectable		 1yvpB-5e6kA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		3 / 3 GLY A 336
GLU A 302
ASN A 389
 None
 0.71A 1zq9A-5e6kA:
undetectable		 1zq9A-5e6kA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 TYR A 199
SER A 169
ALA A 347
SER A 346
 None
 0.98A 2i91A-5e6kA:
undetectable		 2i91A-5e6kA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 TYR A 199
SER A 169
ALA A 347
SER A 346
 None
 0.99A 2i91B-5e6kA:
undetectable		 2i91B-5e6kA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 PHE A  76
TYR A  99
ALA A 238
ALA A 236
GLY A 194
 None
 1.26A 2igtC-5e6kA:
undetectable		 2igtC-5e6kA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 LEU A 156
VAL A 354
LEU A 358
ARG A 180
 None
 1.02A 2oiqA-5e6kA:
undetectable		 2oiqA-5e6kA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 LEU A 499
ARG A 496
ALA A 493
ILE A 469
 None
 0.95A 2qhfA-5e6kA:
undetectable		 2qhfA-5e6kA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 GLY A 336
THR A 369
PHE A 381
PHE A 379
 None
 1.12A 2qx4A-5e6kA:
undetectable
2qx4B-5e6kA:
undetectable		 2qx4A-5e6kA:
16.61
2qx4B-5e6kA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 VAL A 240
GLY A 194
TYR A 120
ILE A 123
GLN A  90
 None
 1.38A 3bwyA-5e6kA:
undetectable		 3bwyA-5e6kA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 GLU A 483
TYR A 455
TYR A 581
PHE A 155
 None
 1.37A 3ku9B-5e6kA:
undetectable		 3ku9B-5e6kA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		3 / 3 ASP A 104
SER A 577
ARG A  21
 None
 1.00A 3loqA-5e6kA:
undetectable		 3loqA-5e6kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 LEU A  86
ARG A  92
LEU A 132
PRO A 591
 None
 1.34A 3onnA-5e6kA:
undetectable		 3onnA-5e6kA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 9 ILE A   7
ILE A   5
VAL A 354
THR A 176
ILE A 419
 None
 1.25A 3p4wB-5e6kA:
undetectable		 3p4wB-5e6kA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLN A 355
GLY A  12
GLY A   9
ALA A 101
PHE A 102
 None
 0.92A 3sudC-5e6kA:
undetectable		 3sudC-5e6kA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLN A 355
GLY A  12
GLY A   9
ALA A 101
PHE A 102
 None
 0.94A 3sudD-5e6kA:
undetectable		 3sudD-5e6kA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 LEU A 492
ALA A 440
MET A 498
PHE A 442
 None
 1.45A 3uq6A-5e6kA:
undetectable		 3uq6A-5e6kA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLY A 353
ALA A 349
SER A 408
VAL A 407
ILE A 421
 None
 0.97A 4ax8A-5e6kA:
undetectable		 4ax8A-5e6kA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 8 TYR A  14
VAL A  20
TYR A  23
LEU A 239
 None
 1.09A 4jtrA-5e6kA:
undetectable		 4jtrA-5e6kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 9 SER A 125
ALA A 148
LEU A 121
GLY A 122
ALA A 580
 None
 1.24A 4l6va-5e6kA:
undetectable
4l6vf-5e6kA:
undetectable		 4l6va-5e6kA:
21.41
4l6vf-5e6kA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 7 GLN A 479
THR A 477
LEU A 578
THR A 464
 None
 1.11A 4mbsA-5e6kA:
undetectable		 4mbsA-5e6kA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 9 ALA A 405
ILE A 258
GLY A 260
ILE A 287
VAL A 357
 None
 1.13A 4nptA-5e6kA:
undetectable		 4nptA-5e6kA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 GLY A 233
GLY A 235
ALA A  33
ILE A  34
ALA A 347
 None
 1.21A 5bw4B-5e6kA:
undetectable		 5bw4B-5e6kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5H_C_ACTC1742_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SUBUNIT)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 5 ASP A  45
LYS A  46
THR A  39
ASP A  43
 None
 1.43A 5g5hC-5e6kA:
0.0		 5g5hC-5e6kA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 8 SER A 169
SER A 409
LYS A 309
SER A 337
 None
 1.10A 5l5fY-5e6kA:
undetectable
5l5fZ-5e6kA:
undetectable		 5l5fY-5e6kA:
16.37
5l5fZ-5e6kA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 SER A 408
GLY A 353
ALA A 352
SER A 171
GLU A 315
 None
 1.48A 5wbvA-5e6kA:
undetectable		 5wbvA-5e6kA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		5 / 12 SER A 408
GLY A 353
ALA A 352
SER A 171
GLU A 315
 None
 1.49A 5wbvB-5e6kA:
undetectable		 5wbvB-5e6kA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		3 / 3 MET A 190
ASP A 252
ARG A 482
 None
 0.96A 5z6jA-5e6kA:
undetectable		 5z6jA-5e6kA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		3 / 3 MET A 190
ASP A 252
ARG A 482
 None
 1.22A 5z6kA-5e6kA:
undetectable		 5z6kA-5e6kA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 8 GLY A 256
ILE A   7
ASP A 252
HIS A 253
 None
 0.89A 6ag0A-5e6kA:
undetectable		 6ag0A-5e6kA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		3 / 3 SER A 279
LYS A 278
SER A 276
 None
 0.72A 6az3P-5e6kA:
undetectable		 6az3P-5e6kA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 6 ILE A 293
TYR A 288
VAL A 420
SER A 297
 None
 1.25A 6f6jA-5e6kA:
undetectable		 6f6jA-5e6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5e6k POLYKETIDE SYNTHASE
PKSL
(Bacillus
subtilis) 		4 / 6 LEU A 578
THR A 477
GLY A 106
ARG A 482
 None
 1.38A 6gtqB-5e6kA:
undetectable
6gtqD-5e6kA:
undetectable		 6gtqB-5e6kA:
14.56
6gtqD-5e6kA:
5.51