SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e6p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		5 / 10 LEU A1530
VAL A1494
TYR A1552
TRP A1521
LEU A1560
 None
 1.12A 1fkoA-5e6pA:
2.1		 1fkoA-5e6pA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K2S_A_H4BA1760_1
(NITRIC-OXIDE
SYNTHASE)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 MET A1393
TRP A1683
PHE A1661
GLU A1402
 None
 1.48A 1k2sA-5e6pA:
undetectable
1k2sB-5e6pA:
undetectable		 1k2sA-5e6pA:
20.94
1k2sB-5e6pA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LZX_B_H4BB1760_1
(NITRIC-OXIDE
SYNTHASE)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.44A 1lzxA-5e6pA:
undetectable
1lzxB-5e6pA:
undetectable		 1lzxA-5e6pA:
20.94
1lzxB-5e6pA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM4_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.40A 1om4A-5e6pA:
undetectable
1om4B-5e6pA:
undetectable		 1om4A-5e6pA:
21.19
1om4B-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 5e6p PLEXIN-B2
(Mus
musculus) 		5 / 12 GLU A1437
HIS A1594
VAL A1469
LEU A1549
THR A1548
 None
 1.03A 1oq5A-5e6pA:
undetectable		 1oq5A-5e6pA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6H_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.48A 1p6hA-5e6pA:
undetectable
1p6hB-5e6pA:
undetectable		 1p6hA-5e6pA:
21.19
1p6hB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.35A 1p6kA-5e6pA:
undetectable
1p6kB-5e6pA:
undetectable		 1p6kA-5e6pA:
21.19
1p6kB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVL_A_H4BA900_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 MET A1393
TRP A1683
PHE A1661
GLU A1402
 None
 1.40A 1zvlA-5e6pA:
undetectable
1zvlB-5e6pA:
2.3		 1zvlA-5e6pA:
22.07
1zvlB-5e6pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 5 ILE A1810
PHE A1332
PHE A1336
ILE A1831
 None
 0.92A 2hjhA-5e6pA:
undetectable		 2hjhA-5e6pA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 6 GLN A1803
PHE A1336
LEU A1340
PHE A1346
 None
 1.14A 3ablP-5e6pA:
2.3
3ablW-5e6pA:
undetectable		 3ablP-5e6pA:
16.96
3ablW-5e6pA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 6 ILE A1432
ILE A1703
LEU A1636
PHE A1639
 None
 1.06A 3adsA-5e6pA:
undetectable		 3adsA-5e6pA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5e6p PLEXIN-B2
RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Homo
sapiens;
Mus
musculus) 		6 / 11 ILE A1831
ALA A1834
ALA A1833
GLN B  70
LEU A1835
ILE A1809
 None
 1.46A 3fc6A-5e6pA:
undetectable		 3fc6A-5e6pA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 MET A1393
TRP A1683
PHE A1661
GLU A1402
 None
 1.45A 3hspA-5e6pA:
undetectable
3hspB-5e6pA:
undetectable		 3hspA-5e6pA:
21.19
3hspB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HSP_B_H4BB1760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.50A 3hspA-5e6pA:
undetectable
3hspB-5e6pA:
undetectable		 3hspA-5e6pA:
21.19
3hspB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JT4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.43A 3jt4A-5e6pA:
undetectable
3jt4B-5e6pA:
undetectable		 3jt4A-5e6pA:
21.19
3jt4B-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N69_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 6 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.49A 3n69A-5e6pA:
0.0
3n69B-5e6pA:
0.0		 3n69A-5e6pA:
21.06
3n69B-5e6pA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.43A 4cx6A-5e6pA:
undetectable
4cx6B-5e6pA:
undetectable		 4cx6A-5e6pA:
21.19
4cx6B-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 5e6p PLEXIN-B2
(Mus
musculus) 		3 / 3 ARG A1783
TYR A1369
ASN A1328
 None
 0.96A 4ffwB-5e6pA:
undetectable		 4ffwB-5e6pA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.40A 4fvwA-5e6pA:
undetectable
4fvwB-5e6pA:
undetectable		 4fvwA-5e6pA:
21.19
4fvwB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.43A 4fvyA-5e6pA:
undetectable
4fvyB-5e6pA:
undetectable		 4fvyA-5e6pA:
21.19
4fvyB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GQE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.44A 4gqeA-5e6pA:
undetectable
4gqeB-5e6pA:
undetectable		 4gqeA-5e6pA:
21.19
4gqeB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMU_A_H4BA809_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 6 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.44A 4imuA-5e6pA:
1.5
4imuB-5e6pA:
undetectable		 4imuA-5e6pA:
21.19
4imuB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_B_SAMB603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5e6p PLEXIN-B2
(Mus
musculus) 		5 / 9 ASP A1299
LEU A1795
VAL A1360
ILE A1302
ASP A1286
 None
 1.45A 4pcuA-5e6pA:
undetectable
4pcuB-5e6pA:
undetectable		 4pcuA-5e6pA:
23.21
4pcuB-5e6pA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.41A 4uh5A-5e6pA:
undetectable
4uh5B-5e6pA:
undetectable		 4uh5A-5e6pA:
21.19
4uh5B-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.34A 5fvuA-5e6pA:
undetectable
5fvuB-5e6pA:
3.1		 5fvuA-5e6pA:
21.19
5fvuB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.37A 5fvvA-5e6pA:
0.9
5fvvB-5e6pA:
2.5		 5fvvA-5e6pA:
21.19
5fvvB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.39A 5fvwA-5e6pA:
0.8
5fvwB-5e6pA:
2.6		 5fvwA-5e6pA:
21.19
5fvwB-5e6pA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5e6p PLEXIN-B2
(Mus
musculus) 		3 / 3 GLY A1364
LEU A1366
HIS A1363
 None
 0.71A 5u63A-5e6pA:
undetectable		 5u63A-5e6pA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5e6p PLEXIN-B2
(Mus
musculus) 		3 / 3 GLY A1364
LEU A1366
HIS A1363
 None
 0.65A 5u63B-5e6pA:
undetectable		 5u63B-5e6pA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5e6p PLEXIN-B2
RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Mus
musculus;
Homo
sapiens) 		4 / 8 GLN B  45
GLY B 121
ILE A1810
GLN A1803
 None
 1.01A 5vlmH-5e6pB:
undetectable		 5vlmH-5e6pB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 6 GLN A1803
PHE A1336
LEU A1340
PHE A1346
 None
 1.07A 5z86C-5e6pA:
2.3
5z86J-5e6pA:
undetectable		 5z86C-5e6pA:
16.96
5z86J-5e6pA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 6 GLN A1803
PHE A1336
LEU A1340
PHE A1346
 None
 1.10A 5zcpC-5e6pA:
2.3
5zcpJ-5e6pA:
undetectable		 5zcpC-5e6pA:
16.96
5zcpJ-5e6pA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 MET A1393
TRP A1683
PHE A1661
GLU A1402
 None
 1.43A 6aurA-5e6pA:
undetectable
6aurB-5e6pA:
undetectable		 6aurA-5e6pA:
9.00
6aurB-5e6pA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 PHE A1661
GLU A1402
MET A1393
TRP A1683
 None
 1.40A 6av3A-5e6pA:
undetectable
6av3B-5e6pA:
undetectable		 6av3A-5e6pA:
9.00
6av3B-5e6pA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 MET A1393
TRP A1683
PHE A1661
GLU A1402
 None
 1.43A 6av4A-5e6pA:
undetectable
6av4B-5e6pA:
undetectable		 6av4A-5e6pA:
9.00
6av4B-5e6pA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		4 / 7 MET A1393
TRP A1683
PHE A1661
GLU A1402
 None
 1.41A 6av5A-5e6pA:
undetectable
6av5B-5e6pA:
undetectable		 6av5A-5e6pA:
9.00
6av5B-5e6pA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		3 / 3 THR A1490
ALA A1443
LYS A1446
 None
 0.72A 6fgcA-5e6pA:
undetectable		 6fgcA-5e6pA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5e6p PLEXIN-B2
(Mus
musculus) 		3 / 3 THR A1490
ALA A1443
LYS A1446
 None
 0.69A 6fgdA-5e6pA:
undetectable		 6fgdA-5e6pA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5e6p PLEXIN-B2
RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11
(Mus
musculus;
Homo
sapiens) 		4 / 5 GLY B  63
LEU B  68
TYR A1799
GLN A1803
 None
 1.24A 6ji6A-5e6pB:
undetectable		 6ji6A-5e6pB:
20.18