SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 ALA A 349
VAL A 343
TRP A 348
 None
 0.69A 1bdwA-5e6sA:
undetectable
1bdwB-5e6sA:
undetectable		 1bdwA-5e6sA:
1.61
1bdwB-5e6sA:
1.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		6 / 10 LEU A 132
VAL A 233
ILE A 235
TYR A 257
LYS A 287
LEU A 298
 None
 0.40A 1cqpA-5e6sA:
33.1
1cqpB-5e6sA:
32.9		 1cqpA-5e6sA:
100.00
1cqpB-5e6sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 7 LEU A 132
VAL A 233
TYR A 257
LYS A 287
LEU A 298
 None
 0.47A 1cqpA-5e6sA:
33.1
1cqpB-5e6sA:
32.9		 1cqpA-5e6sA:
100.00
1cqpB-5e6sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 GLY A 494
ALA A 525
TYR A 491
GLU A 545
 None
 0.73A 1dmaB-5e6sA:
undetectable		 1dmaB-5e6sA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 ILE B 297
ALA B 240
LYS B 335
ILE B 144
LEU B 135
 None
 1.11A 1dyiB-5e6sB:
undetectable		 1dyiB-5e6sB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 7 LEU A  70
THR A  66
LEU A  90
GLY A  89
 None
 0.87A 1gtiB-5e6sA:
undetectable		 1gtiB-5e6sA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 SER A 270
THR A 267
GLU A 241
GLY A 240
 None
None
None
MG  A2001 ( 4.4A)
 1.17A 1icrA-5e6sA:
undetectable
1icrB-5e6sA:
undetectable		 1icrA-5e6sA:
14.39
1icrB-5e6sA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 GLU A 241
GLY A 240
SER A 270
THR A 267
 None
MG  A2001 ( 4.4A)
None
None
 1.19A 1icrA-5e6sA:
undetectable
1icrB-5e6sA:
undetectable		 1icrA-5e6sA:
14.39
1icrB-5e6sA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 SER A 270
THR A 267
GLU A 241
GLY A 240
 None
None
None
MG  A2001 ( 4.4A)
 1.16A 1icuA-5e6sA:
undetectable
1icuB-5e6sA:
undetectable		 1icuA-5e6sA:
14.39
1icuB-5e6sA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 SER A 270
THR A 267
GLU A 241
GLY A 240
 None
None
None
MG  A2001 ( 4.4A)
 1.11A 1icuC-5e6sA:
undetectable
1icuD-5e6sA:
undetectable		 1icuC-5e6sA:
14.39
1icuD-5e6sA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 SER A 270
THR A 267
GLU A 241
GLY A 240
 None
None
None
MG  A2001 ( 4.4A)
 1.15A 1icvC-5e6sA:
undetectable
1icvD-5e6sA:
undetectable		 1icvC-5e6sA:
14.39
1icvD-5e6sA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 GLU A 241
GLY A 240
SER A 270
THR A 267
 None
MG  A2001 ( 4.4A)
None
None
 1.19A 1icvC-5e6sA:
undetectable
1icvD-5e6sA:
undetectable		 1icvC-5e6sA:
14.39
1icvD-5e6sA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 GLU A 241
GLY A 240
SER A 270
THR A 267
 None
MG  A2001 ( 4.4A)
None
None
 1.17A 1kqbA-5e6sA:
undetectable
1kqbB-5e6sA:
undetectable		 1kqbA-5e6sA:
14.63
1kqbB-5e6sA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 GLU A 241
GLY A 240
SER A 270
THR A 267
 None
MG  A2001 ( 4.4A)
None
None
 1.16A 1kqbC-5e6sA:
undetectable
1kqbD-5e6sA:
undetectable		 1kqbC-5e6sA:
14.63
1kqbD-5e6sA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 ALA A 345
ALA A 349
GLY A 351
PHE A 364
GLN A 422
 None
 1.08A 1qabF-5e6sA:
undetectable		 1qabF-5e6sA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		4 / 7 THR B  65
ALA B  63
SER B  61
VAL B  81
 None
 0.99A 1tyrB-5e6sB:
undetectable		 1tyrB-5e6sB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		6 / 12 LEU A 536
SER A 537
PRO A 538
ILE A 471
GLY A 534
GLY A 535
 None
 1.20A 1uakA-5e6sA:
3.7		 1uakA-5e6sA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 LEU A 503
GLY A 562
HIS A 561
ILE A 560
 None
 0.73A 1xf1A-5e6sA:
2.6		 1xf1A-5e6sA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 LEU A 503
GLY A 562
HIS A 561
ILE A 560
 None
 0.73A 1xf1B-5e6sA:
2.8		 1xf1B-5e6sA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 LEU A 394
ASP A 447
ASP A 443
GLY A 448
PHE A 479
 None
CA  A2002 (-2.4A)
CA  A2002 (-3.1A)
None
None
 0.99A 1zz1B-5e6sA:
undetectable
1zz1C-5e6sA:
undetectable		 1zz1B-5e6sA:
18.64
1zz1C-5e6sA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 LEU A 111
ALA A  75
LEU A 333
SER A  82
ASP A  80
 None
 1.03A 2c12C-5e6sA:
undetectable		 2c12C-5e6sA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 11 LEU A 111
ALA A  75
LEU A 333
SER A  82
ASP A  80
 None
 1.02A 2c12F-5e6sA:
undetectable		 2c12F-5e6sA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2
(Homo
sapiens) 		4 / 7 ARG A 495
ASN B 260
ASP B 278
GLY B 283
 None
 0.87A 2f6dA-5e6sA:
undetectable		 2f6dA-5e6sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 HIS A 427
ALA A 399
GLY A 406
VAL A 374
GLY A 350
 None
 1.15A 2f8lA-5e6sA:
undetectable		 2f8lA-5e6sA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 ARG B 371
GLN B 390
ASN B  94
LEU B  85
 None
NAG  B3094 ( 4.5A)
NAG  B3094 (-1.9A)
None
 1.00A 2nyrA-5e6sB:
2.2		 2nyrA-5e6sB:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 THR A  79
THR A  76
ASP A 332
THR A 384
 None
 1.14A 2okcB-5e6sA:
2.0		 2okcB-5e6sA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 PHE B 146
TYR B 109
LEU B 237
SER B 116
SER B 114
 None
 1.30A 2vdmA-5e6sB:
undetectable
2vdmB-5e6sB:
30.6		 2vdmA-5e6sB:
22.14
2vdmB-5e6sB:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 LEU A  25
ARG A  23
ILE A  32
 None
 0.53A 2xn5B-5e6sA:
undetectable		 2xn5B-5e6sA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 LEU A 454
ILE A 471
ARG A 532
VAL A   5
 None
 1.02A 2ygoA-5e6sA:
undetectable		 2ygoA-5e6sA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 8 ILE A 126
ASN A 129
SER A 165
ASP A  95
 None
 1.09A 2zw9B-5e6sA:
1.4		 2zw9B-5e6sA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 LEU A 454
ILE A 500
GLY A 456
LEU A 536
GLU A 484
 None
 1.13A 3ai9X-5e6sA:
3.8		 3ai9X-5e6sA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 TYR B 279
HIS B 246
ASP B 209
ASP B 151
ILE B 256
 None
None
CA  B2003 (-3.0A)
CA  B2003 (-3.4A)
None
 1.25A 3b7pA-5e6sB:
undetectable		 3b7pA-5e6sB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 TYR B 279
HIS B 246
ASP B 209
ASP B 151
ILE B 256
 None
None
CA  B2003 (-3.0A)
CA  B2003 (-3.4A)
None
 1.31A 3b7pB-5e6sB:
undetectable		 3b7pB-5e6sB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 TYR B 279
HIS B 246
ASP B 209
ASP B 151
ILE B 256
 None
None
CA  B2003 (-3.0A)
CA  B2003 (-3.4A)
None
 1.27A 3b7pC-5e6sB:
undetectable		 3b7pC-5e6sB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 ALA A 499
GLN A  26
VAL A 576
ILE A 528
LEU A   3
 None
 1.15A 3datA-5e6sA:
undetectable		 3datA-5e6sA:
11.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 ILE A 235
TYR A 257
ILE A 259
LEU A 298
GLU A 301
 None
 0.87A 3f78A-5e6sA:
34.9		 3f78A-5e6sA:
76.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 ILE A 235
TYR A 257
ILE A 259
LYS A 287
LEU A 298
 None
 0.38A 3f78A-5e6sA:
34.9		 3f78A-5e6sA:
76.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 ILE A 235
TYR A 257
ILE A 259
LYS A 287
LEU A 298
 None
 0.34A 3f78B-5e6sA:
35.0		 3f78B-5e6sA:
76.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 ILE A 560
ALA A   8
ALA A 578
VAL A 526
PRO A 519
 None
 0.88A 3jb2A-5e6sA:
undetectable		 3jb2A-5e6sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 11 GLY B 142
LEU B 107
LEU B 188
LEU B 131
LEU B 132
 None
 1.36A 3ndvA-5e6sB:
undetectable
3ndvB-5e6sB:
undetectable		 3ndvA-5e6sB:
20.77
3ndvB-5e6sB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 11 LEU B 131
LEU B 132
GLY B 142
LEU B 107
LEU B 188
 None
 1.37A 3ndvA-5e6sB:
undetectable
3ndvB-5e6sB:
undetectable		 3ndvA-5e6sB:
20.77
3ndvB-5e6sB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 11 GLY B 142
LEU B 107
LEU B 188
LEU B 131
LEU B 132
 None
 1.38A 3ndvC-5e6sB:
undetectable
3ndvD-5e6sB:
undetectable		 3ndvC-5e6sB:
20.77
3ndvD-5e6sB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 11 LEU B 131
LEU B 132
GLY B 142
LEU B 107
LEU B 188
 None
 1.35A 3ndvC-5e6sB:
undetectable
3ndvD-5e6sB:
undetectable		 3ndvC-5e6sB:
20.77
3ndvD-5e6sB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 11 TYR A  22
GLY A 557
ALA A 578
ILE A 560
ALA A 499
 None
 1.17A 3nmuB-5e6sA:
undetectable
3nmuJ-5e6sA:
undetectable		 3nmuB-5e6sA:
19.05
3nmuJ-5e6sA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 TYR A   1
ASP A 505
ASP A 445
 None
CA  A2003 (-3.4A)
None
 0.88A 3ou6B-5e6sA:
undetectable		 3ou6B-5e6sA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		4 / 5 LEU B 215
GLY B 213
PHE B 149
PHE B 239
 None
 1.16A 3smtA-5e6sB:
undetectable		 3smtA-5e6sB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 6 THR A 243
ASN A 207
GLY A 210
ILE A 236
 None
 0.88A 3w9tF-5e6sA:
undetectable		 3w9tF-5e6sA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLY A 406
PHE B 247
ILE A 431
PHE B 245
 None
 0.90A 4fglD-5e6sA:
5.7		 4fglD-5e6sA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 7 GLY A 494
ALA A 525
TYR A 491
GLU A 545
 None
 0.88A 4hyfA-5e6sA:
undetectable		 4hyfA-5e6sA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 8 GLY A 494
ALA A 525
TYR A 491
GLU A 545
 None
 0.90A 4hyfC-5e6sA:
undetectable		 4hyfC-5e6sA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 LEU B 333
LEU B 110
PRO B 296
ASP B 242
ASP B 243
 None
 1.18A 4j7xJ-5e6sB:
3.6		 4j7xJ-5e6sB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 7 ILE A 544
PHE A 556
LEU A 585
THR A 501
 None
 1.07A 4mmcA-5e6sA:
undetectable		 4mmcA-5e6sA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2
(Homo
sapiens) 		5 / 10 TYR A  69
VAL A 343
ALA A 342
GLY B 254
SER A 101
 None
 1.27A 4mmdA-5e6sA:
undetectable		 4mmdA-5e6sA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		6 / 12 LEU A 410
GLY A 437
GLY A 436
ALA A 396
LEU A 453
GLY A 377
 None
 1.15A 4n09C-5e6sA:
undetectable		 4n09C-5e6sA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 GLY A 406
PHE B 247
ILE A 431
PHE B 245
 None
 0.88A 4qogA-5e6sA:
5.8
4qogB-5e6sA:
5.9		 4qogA-5e6sA:
15.33
4qogB-5e6sA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2
(Homo
sapiens) 		4 / 8 ILE A 431
LEU B 311
TYR B 308
LEU B 215
 None
 0.93A 4qopC-5e6sA:
undetectable		 4qopC-5e6sA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 ALA A 578
GLY A 546
ILE A 528
ALA A 515
GLY A 517
 None
 1.03A 4r29D-5e6sA:
undetectable		 4r29D-5e6sA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 10 GLY A  81
LEU A  25
ALA A  75
ASP A 332
ALA A 338
 None
 1.35A 4wnuD-5e6sA:
undetectable		 4wnuD-5e6sA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 LEU A   3
ASP A   4
GLY A   7
ALA A   8
VAL A 576
 None
 0.98A 4xdrA-5e6sA:
undetectable		 4xdrA-5e6sA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 ARG A  18
GLY A  17
GLU A  38
SER A  10
 None
 1.09A 4z3oA-5e6sA:
undetectable
4z3oB-5e6sA:
2.2		 4z3oA-5e6sA:
22.68
4z3oB-5e6sA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		3 / 3 LYS B 272
ARG B 273
HIS B 265
 None
 1.10A 4zbrA-5e6sB:
undetectable		 4zbrA-5e6sB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 8 SER A 330
GLY A 341
ALA A 376
GLY A 350
 None
 0.68A 5albL-5e6sA:
undetectable		 5albL-5e6sA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 GLU A 180
THR A 206
HIS A 264
LEU A 142
 None
MG  A2001 (-4.3A)
None
None
 1.27A 5axaA-5e6sA:
3.7		 5axaA-5e6sA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 GLU A 180
THR A 206
HIS A 264
LEU A 142
 None
MG  A2001 (-4.3A)
None
None
 1.27A 5axaC-5e6sA:
3.5		 5axaC-5e6sA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 7 SER A  10
ARG A  18
GLY A  17
GLU A  38
 None
 1.07A 5btfA-5e6sA:
undetectable
5btfC-5e6sA:
undetectable
5btfD-5e6sA:
undetectable		 5btfA-5e6sA:
22.07
5btfC-5e6sA:
22.07
5btfD-5e6sA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 SER A  10
ARG A  18
GLY A  17
GLU A  38
 None
 1.18A 5cdqA-5e6sA:
undetectable
5cdqB-5e6sA:
2.5
5cdqC-5e6sA:
undetectable		 5cdqA-5e6sA:
20.76
5cdqB-5e6sA:
12.06
5cdqC-5e6sA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 5 SER A  10
ARG A  18
GLY A  17
GLU A  38
 None
 1.17A 5cdqR-5e6sA:
undetectable
5cdqS-5e6sA:
2.5
5cdqT-5e6sA:
undetectable		 5cdqR-5e6sA:
20.76
5cdqS-5e6sA:
12.06
5cdqT-5e6sA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		4 / 5 VAL B 124
VAL B 199
GLY B 200
PHE B 195
 None
 1.09A 5d4nA-5e6sB:
undetectable
5d4nC-5e6sB:
undetectable		 5d4nA-5e6sB:
13.68
5d4nC-5e6sB:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 11 ALA B  91
ALA B  63
VAL B  81
LEU B 356
VAL B 417
 None
 1.14A 5eb5A-5e6sB:
1.4		 5eb5A-5e6sB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 10 ALA B  91
ALA B  63
VAL B  81
LEU B 356
VAL B 417
 None
 1.10A 5eb5B-5e6sB:
undetectable		 5eb5B-5e6sB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 MET A 405
GLN A 403
ARG A 407
 None
 0.88A 5ewzB-5e6sA:
undetectable		 5ewzB-5e6sA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		4 / 4 VAL A 444
GLU A 451
GLY A 535
LEU A 536
 None
CA  A2002 (-3.0A)
None
None
 1.01A 5g5gC-5e6sA:
undetectable		 5g5gC-5e6sA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 VAL A  58
ILE A  83
LEU A 111
PRO A  57
LEU A 359
 None
 1.14A 5ienA-5e6sA:
undetectable		 5ienA-5e6sA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 10 VAL A  58
ILE A  83
LEU A 111
PRO A  57
LEU A 359
 None
 1.12A 5ienB-5e6sA:
undetectable		 5ienB-5e6sA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		3 / 3 GLY B 262
GLN B 220
LYS B 288
 None
 0.98A 5imsB-5e6sB:
2.6		 5imsB-5e6sB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 MET A 405
GLN A 403
ARG A 407
 None
 0.80A 5m35B-5e6sA:
undetectable		 5m35B-5e6sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 MET A 405
GLN A 403
ARG A 407
 None
 0.79A 5m36A-5e6sA:
undetectable		 5m36A-5e6sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		6 / 9 ALA B  91
VAL B 393
ILE B 406
ASN B  94
PHE B  93
ALA B  63
 None
None
None
NAG  B3094 (-1.9A)
None
None
 1.21A 5nunA-5e6sB:
undetectable		 5nunA-5e6sB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 0.99A 5vooA-5e6sB:
undetectable		 5vooA-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.00A 5vooB-5e6sB:
undetectable		 5vooB-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.01A 5vooC-5e6sB:
undetectable		 5vooC-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.01A 5vooD-5e6sB:
2.6		 5vooD-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 12 GLY A 517
MET A 582
VAL A  31
LEU A  25
GLY A 562
 None
 1.14A 5vooE-5e6sA:
undetectable		 5vooE-5e6sA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
ASP B 209
GLY B 206
SER B 114
 None
None
CA  B2003 (-3.0A)
None
None
 1.20A 5vooE-5e6sB:
undetectable		 5vooE-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.08A 5vooE-5e6sB:
undetectable		 5vooE-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
ASP B 209
GLY B 206
SER B 114
 None
None
CA  B2003 (-3.0A)
None
None
 1.18A 5vooF-5e6sB:
2.5		 5vooF-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.06A 5vooF-5e6sB:
2.5		 5vooF-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.04A 5vopA-5e6sB:
undetectable		 5vopA-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		5 / 12 GLU B 212
GLY B 213
LEU B 165
GLY B 206
SER B 114
 None
 1.12A 5vopB-5e6sB:
undetectable		 5vopB-5e6sB:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 GLY B 213
PRO B 211
HIS A 404
ASP B 151
PHE B 182
 None
None
None
CA  B2003 (-3.4A)
None
 1.10A 5x6yC-5e6sB:
undetectable		 5x6yC-5e6sB:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 GLY A 328
VAL A 340
ASP A  87
GLY A 102
PRO A 120
 None
 1.34A 5zniA-5e6sA:
undetectable		 5zniA-5e6sA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 ASP A 249
ALA A 211
ILE A 212
GLY A 246
PHE A 209
 None
 1.22A 6awoA-5e6sA:
undetectable		 6awoA-5e6sA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		5 / 9 ASP A 249
ALA A 211
ILE A 212
GLY A 246
PHE A 209
 None
 1.22A 6awqA-5e6sA:
undetectable		 6awqA-5e6sA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5e6s INTEGRIN BETA-2
(Homo
sapiens) 		4 / 5 GLU B 276
ASP B 261
HIS B 265
THR B 258
 None
 1.35A 6b58A-5e6sB:
undetectable		 6b58A-5e6sB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 MET A 405
GLN A 403
ARG A 407
 None
 0.78A 6fn9A-5e6sA:
undetectable		 6fn9A-5e6sA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 MET A 405
GLN A 403
ARG A 407
 None
 0.79A 6fnaB-5e6sA:
undetectable		 6fnaB-5e6sA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 MET A 405
GLN A 403
ARG A 407
 None
 0.78A 6fnbA-5e6sA:
undetectable		 6fnbA-5e6sA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5e6s INTEGRIN ALPHA-L
(Homo
sapiens) 		3 / 3 ARG A 474
LEU A 394
PHE A 411
 None
 0.76A 6nknP-5e6sA:
undetectable		 6nknP-5e6sA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 5e6s INTEGRIN ALPHA-L
INTEGRIN BETA-2
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PRO B 156
LEU B 253
ILE A 329
LEU A  84
GLY A 102
 None
 1.05A 6qxsB-5e6sB:
undetectable		 6qxsB-5e6sB:
19.96