SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5e6v INTEGRIN BETA-2
(Homo
sapiens) 		5 / 10 PHE A  93
VAL A 391
VAL A 417
VAL A 419
LEU A 356
 None
 1.20A 1fe2A-5e6vA:
undetectable		 1fe2A-5e6vA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5e6v INTEGRIN BETA-2
(Homo
sapiens) 		4 / 6 ARG A 371
GLN A 390
ASN A  94
LEU A  85
 NAG  A 501 (-3.5A)
NAG  A 502 (-3.8A)
NAG  A 502 (-1.8A)
None
 0.76A 2nyrA-5e6vA:
undetectable		 2nyrA-5e6vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5e6v INTEGRIN BETA-2
(Homo
sapiens) 		6 / 9 ALA A  91
VAL A 393
ILE A 406
ASN A  94
PHE A  93
ALA A  63
 None
None
None
NAG  A 502 (-1.8A)
None
None
 1.20A 5nunA-5e6vA:
undetectable		 5nunA-5e6vA:
19.67