SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e7j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 8 GLU A 366
LEU A 392
ALA A 349
LEU A 353
 None
 1.05A 1hwiB-5e7jA:
undetectable		 1hwiB-5e7jA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 LEU A 150
SER A 290
PHE A 289
LEU A 239
 None
 0.79A 1j8uA-5e7jA:
undetectable		 1j8uA-5e7jA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		6 / 12 PHE A 447
LEU A 445
ILE A 471
ALA A 497
ALA A 499
ARG A 528
 None
 1.41A 2fr3A-5e7jA:
undetectable		 2fr3A-5e7jA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 6 LEU A 457
ASN A 436
ILE A 514
PHE A 516
 None
 0.89A 2jn3A-5e7jA:
undetectable		 2jn3A-5e7jA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 CYH A 223
SER A 382
ALA A 349
ILE A 389
LEU A 397
 None
 0.94A 3adsB-5e7jA:
undetectable		 3adsB-5e7jA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 6 MET A 330
ARG A 311
PRO A 267
GLY A 316
 None
 1.36A 3aqiA-5e7jA:
4.0		 3aqiA-5e7jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 6 MET A 330
ARG A 311
PRO A 267
GLY A 316
 None
 1.25A 3aqiB-5e7jA:
undetectable		 3aqiB-5e7jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 GLY A 530
ARG A 351
VAL A 513
ILE A 415
ASN A 414
 None
 1.37A 3jb2A-5e7jA:
undetectable		 3jb2A-5e7jA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 ASN A 509
ASP A 354
ARG A 407
 None
 0.91A 3k13A-5e7jA:
undetectable		 3k13A-5e7jA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 PRO A 297
VAL A 295
TYR A 243
ILE A 238
TYR A 343
 None
 1.35A 3q5pA-5e7jA:
undetectable		 3q5pA-5e7jA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 5 LEU A 320
ARG A 326
ILE A 306
ARG A 333
 None
 1.36A 3ticA-5e7jA:
undetectable		 3ticA-5e7jA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 LEU A 235
ILE A 214
ILE A 282
ALA A 273
PHE A 381
 None
 1.22A 3vw1D-5e7jA:
undetectable		 3vw1D-5e7jA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 10 LEU A 403
THR A 378
ASP A 219
TYR A 400
PHE A 402
 None
 1.29A 4driB-5e7jA:
undetectable		 4driB-5e7jA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 GLY A 325
PRO A 324
ALA A 273
 None
 0.48A 4qn9B-5e7jA:
undetectable		 4qn9B-5e7jA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 GLU A 285
ALA A 286
PHE A 289
 AMP  A 801 ( 4.5A)
None
None
 0.63A 4v1fA-5e7jA:
undetectable		 4v1fA-5e7jA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 GLU A 285
ALA A 286
PHE A 289
 AMP  A 801 ( 4.5A)
None
None
 0.64A 4v1fC-5e7jA:
undetectable		 4v1fC-5e7jA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 11 CYH A 223
SER A 382
ALA A 349
ILE A 389
LEU A 397
 None
 0.95A 4xumB-5e7jA:
undetectable		 4xumB-5e7jA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 11 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
AMP  A 801 (-3.5A)
AMP  A 801 ( 4.3A)
 1.46A 4ygfA-5e7jA:
undetectable		 4ygfA-5e7jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 11 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
AMP  A 801 (-3.5A)
AMP  A 801 ( 4.3A)
 1.46A 4ygfC-5e7jA:
undetectable		 4ygfC-5e7jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
AMP  A 801 (-3.5A)
AMP  A 801 ( 4.3A)
 1.50A 4ygfG-5e7jA:
undetectable		 4ygfG-5e7jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 12 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
AMP  A 801 (-3.5A)
AMP  A 801 ( 4.3A)
 1.46A 4yhaG-5e7jA:
undetectable		 4yhaG-5e7jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 ASP A 329
ARG A 333
GLY A 334
ARG A 363
 None
 0.83A 5bs8A-5e7jA:
undetectable
5bs8B-5e7jA:
undetectable
5bs8C-5e7jA:
undetectable		 5bs8A-5e7jA:
22.59
5bs8B-5e7jA:
23.24
5bs8C-5e7jA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 ARG A 363
ASP A 329
ARG A 333
GLY A 334
 None
 0.79A 5btaA-5e7jA:
undetectable
5btaC-5e7jA:
undetectable
5btaD-5e7jA:
2.2		 5btaA-5e7jA:
22.59
5btaC-5e7jA:
22.59
5btaD-5e7jA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 7 ASP A 329
ARG A 333
GLY A 334
ARG A 363
 None
 0.75A 5btfA-5e7jA:
undetectable
5btfB-5e7jA:
undetectable
5btfC-5e7jA:
undetectable		 5btfA-5e7jA:
22.59
5btfB-5e7jA:
23.24
5btfC-5e7jA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 6 ARG A 363
ASP A 329
ARG A 333
GLY A 334
 None
 0.81A 5cdqA-5e7jA:
undetectable
5cdqC-5e7jA:
undetectable
5cdqD-5e7jA:
2.0		 5cdqA-5e7jA:
22.08
5cdqC-5e7jA:
22.08
5cdqD-5e7jA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 9 LEU A 403
THR A 378
ASP A 219
TYR A 400
PHE A 402
 None
 1.28A 5gpgB-5e7jA:
0.0		 5gpgB-5e7jA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 6 GLU A 284
ALA A 232
LEU A 236
TYR A 291
 None
AMP  A 801 ( 4.3A)
None
None
 1.03A 5igiA-5e7jA:
undetectable		 5igiA-5e7jA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_A_ACTA402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 5 CYH A 175
ILE A 213
HIS A 209
HIS A 178
 None
 1.27A 5ocsA-5e7jA:
undetectable		 5ocsA-5e7jA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OCS_C_ACTC402_0
(PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 5 CYH A 175
ILE A 213
HIS A 209
HIS A 178
 None
 1.27A 5ocsC-5e7jA:
undetectable		 5ocsC-5e7jA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 9 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
AMP  A 801 (-3.5A)
AMP  A 801 ( 4.3A)
 1.42A 5tt3E-5e7jA:
undetectable		 5tt3E-5e7jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		5 / 9 VAL A 345
VAL A 271
LEU A 235
THR A 231
ALA A 232
 None
None
None
AMP  A 801 (-3.5A)
AMP  A 801 ( 4.3A)
 1.45A 5tt3G-5e7jA:
undetectable		 5tt3G-5e7jA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		4 / 8 GLY A 302
GLU A 481
ILE A 306
ASP A 329
 None
 1.04A 5vlmD-5e7jA:
undetectable		 5vlmD-5e7jA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens) 		3 / 3 GLY A 229
THR A 231
GLU A 285
 AMP  A 801 (-3.2A)
AMP  A 801 (-3.5A)
AMP  A 801 ( 4.5A)
 0.66A 6b58A-5e7jA:
undetectable		 6b58A-5e7jA:
21.49