SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e7s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 6 ASP A 669
GLY A 670
THR A 672
PRO A 673
 None
 0.81A 1n4fA-5e7sA:
undetectable		 1n4fA-5e7sA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 6 LEU A 769
ALA A 597
SER A 689
THR A 596
 None
 0.98A 1tyrA-5e7sA:
undetectable		 1tyrA-5e7sA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 SER A 636
GLU A 705
ASP A 761
GLY A 710
VAL A 765
 None
 1.30A 2kceA-5e7sA:
undetectable		 2kceA-5e7sA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 5 GLU A 705
PRO A 714
ILE A 715
GLY A 704
 None
 1.19A 2qeuA-5e7sA:
undetectable
2qeuC-5e7sA:
undetectable		 2qeuA-5e7sA:
19.05
2qeuC-5e7sA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 9 LEU A 625
ILE A 687
ALA A 686
THR A 682
ALA A 679
 None
 1.32A 3mdtA-5e7sA:
undetectable		 3mdtA-5e7sA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 7 LEU A 769
ALA A 597
SER A 689
THR A 596
 None
 1.02A 3ozkB-5e7sA:
undetectable		 3ozkB-5e7sA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 11 ALA A 502
ILE A 527
ILE A 574
LEU A 578
ILE A 550
 None
 1.08A 4dt8A-5e7sA:
undetectable		 4dt8A-5e7sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 10 ALA A 502
ILE A 527
ILE A 574
LEU A 578
ILE A 550
 None
 1.04A 4dt8B-5e7sA:
undetectable		 4dt8B-5e7sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 10 ALA A 502
ILE A 527
ILE A 574
LEU A 578
ILE A 550
 None
 1.07A 4dtaA-5e7sA:
undetectable		 4dtaA-5e7sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 8 GLY A 599
LEU A 610
ILE A 612
THR A 682
 None
 0.79A 4em2A-5e7sA:
undetectable		 4em2A-5e7sA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 6 LEU A 769
ALA A 597
SER A 689
THR A 596
 None
 1.04A 4ikiB-5e7sA:
undetectable		 4ikiB-5e7sA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 6 ARG A 503
ALA A 502
ASP A 524
LEU A 547
 None
 1.06A 4ot2A-5e7sA:
undetectable		 4ot2A-5e7sA:
18.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		9 / 12 LEU A 610
MET A 633
THR A 672
LYS A 674
GLY A 676
PRO A 677
SER A 678
ALA A 679
LYS A 721
 None
 0.71A 4ypmA-5e7sA:
41.6		 4ypmA-5e7sA:
96.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ALA A 688
LEU A 766
GLY A 607
THR A 603
LEU A 610
 None
 1.08A 5eshA-5e7sA:
undetectable		 5eshA-5e7sA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		3 / 3 THR A 523
ASP A 524
ALA A 525
 None
 0.00A 5g5gB-5e7sA:
undetectable		 5g5gB-5e7sA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 THR A 608
LEU A 609
ALA A 724
ILE A 715
GLY A 717
 None
 1.16A 5gs4A-5e7sA:
undetectable		 5gs4A-5e7sA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 GLY A 716
GLY A 630
VAL A 632
THR A 608
GLY A 607
 None
 0.94A 5koxA-5e7sA:
undetectable		 5koxA-5e7sA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ILE A 687
VAL A 661
ALA A 686
MET A 683
VAL A 665
 None
 1.14A 5n0rA-5e7sA:
undetectable		 5n0rA-5e7sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 ILE A 687
VAL A 661
ALA A 686
MET A 683
VAL A 665
 None
 1.13A 5n0wA-5e7sA:
undetectable		 5n0wA-5e7sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		5 / 12 GLY A 717
ASN A 739
GLU A 740
LEU A 743
LEU A 746
 None
 1.22A 5nwvA-5e7sA:
undetectable		 5nwvA-5e7sA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		3 / 3 GLU A 533
TYR A 583
ARG A 536
 None
 0.82A 5uunA-5e7sA:
undetectable		 5uunA-5e7sA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		3 / 3 GLU A 533
TYR A 583
ARG A 536
 None
 0.74A 5uunB-5e7sA:
undetectable		 5uunB-5e7sA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5e7s LON PROTEASE
(Meiothermus
taiwanensis) 		4 / 6 MET A 683
THR A 682
MET A 633
LEU A 735
 None
 1.11A 6mvxA-5e7sA:
undetectable
6mvxB-5e7sA:
undetectable
6mvxC-5e7sA:
undetectable		 6mvxA-5e7sA:
23.69
6mvxB-5e7sA:
23.69
6mvxC-5e7sA:
23.69