SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5e7t MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009) 		4 / 8 MET B  58
LEU B  69
VAL B 177
GLY B  54
 None
 0.81A 1hrkA-5e7tB:
undetectable		 1hrkA-5e7tB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5e7t MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009) 		4 / 8 MET B  58
LEU B  69
VAL B 177
GLY B  54
 None
 0.81A 1hrkB-5e7tB:
undetectable		 1hrkB-5e7tB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 5e7t MAJOR STRUCTURAL
PROTEIN 1
(Lactococcus
phage
Tuc2009) 		5 / 10 ASP G 153
MET G 132
ILE G 104
TYR G  92
GLY G 158
 None
 1.49A 1pn0A-5e7tG:
undetectable		 1pn0A-5e7tG:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 5e7t MAJOR STRUCTURAL
PROTEIN 1
(Lactococcus
phage
Tuc2009) 		5 / 10 ASP G 153
MET G 132
ILE G 104
TYR G  92
GLY G 158
 None
 1.50A 1pn0B-5e7tG:
undetectable		 1pn0B-5e7tG:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 5e7t MAJOR STRUCTURAL
PROTEIN 1
(Lactococcus
phage
Tuc2009) 		5 / 10 ASP G 153
MET G 132
ILE G 104
TYR G  92
GLY G 158
 None
 1.49A 1pn0C-5e7tG:
undetectable		 1pn0C-5e7tG:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 5e7t MAJOR STRUCTURAL
PROTEIN 1
(Lactococcus
phage
Tuc2009) 		5 / 10 ASP G 153
MET G 132
ILE G 104
TYR G  92
GLY G 158
 None
 1.49A 1pn0D-5e7tG:
undetectable		 1pn0D-5e7tG:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5e7t MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009) 		5 / 12 GLY B 164
GLY B 171
GLY B  60
ALA B  63
ASN B  98
 None
 1.15A 2dpmA-5e7tB:
undetectable		 2dpmA-5e7tB:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5e7t MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009) 		4 / 8 MET B  58
LEU B  69
VAL B 177
GLY B  54
 None
 0.82A 2po5A-5e7tB:
undetectable		 2po5A-5e7tB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5e7t MINOR STRUCTURAL
PROTEIN 4
MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009) 		5 / 10 THR B   9
SER B 247
SER A 317
VAL B 233
GLY B 241
 None
 1.46A 2x2iD-5e7tB:
undetectable		 2x2iD-5e7tB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5e7t MINOR STRUCTURAL
PROTEIN 4
MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009) 		4 / 5 GLY A 321
PRO A 301
ASN A 320
TYR B 231
 None
 1.18A 3u8qA-5e7tA:
undetectable		 3u8qA-5e7tA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5e7t MINOR STRUCTURAL
PROTEIN 4
MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009;
Lactococcus
phage
Tuc2009) 		3 / 3 LYS A 315
ASN B 252
ASP A 308
 None
 0.82A 4o1eA-5e7tA:
undetectable		 4o1eA-5e7tA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5e7t MAJOR STRUCTURAL
PROTEIN 1
(Lactococcus
phage
Tuc2009) 		4 / 5 GLY G  94
ALA G 129
GLY G 160
PRO G 161
 None
 0.97A 4u9uB-5e7tG:
undetectable		 4u9uB-5e7tG:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5e7t MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009) 		4 / 5 ALA B  10
TYR B  11
GLY B 256
LEU B 235
 None
 0.88A 5eslA-5e7tB:
undetectable		 5eslA-5e7tB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5e7t MINOR STRUCTURAL
PROTEIN 5
(Lactococcus
phage
Tuc2009) 		4 / 7 ARG B 232
TYR B 234
GLU B 271
LEU B  28
 None
 1.06A 5umwB-5e7tB:
undetectable
5umwE-5e7tB:
undetectable		 5umwB-5e7tB:
12.23
5umwE-5e7tB:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 5e7t MINOR STRUCTURAL
PROTEIN 4
MAJOR STRUCTURAL
PROTEIN 1
(Lactococcus
phage
Tuc2009;
Lactococcus
phage
Tuc2009) 		3 / 3 ARG G   9
PHE A 232
GLY A 234
 None
 0.77A 6fgdA-5e7tG:
undetectable		 6fgdA-5e7tG:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5e7t MINOR STRUCTURAL
PROTEIN 4
(Lactococcus
phage
Tuc2009) 		4 / 7 GLY A 225
ASN A 217
GLU A 279
GLY A 277
 None
 0.89A 6n7fA-5e7tA:
undetectable		 6n7fA-5e7tA:
24.03