SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e84'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.08A 1c8lA-5e84A:
undetectable
1c8lA-5e84A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 4 THR A 557
LEU A 561
LEU A 568
GLN A 571
None
1.16A 1fbmA-5e84A:
undetectable
1fbmA-5e84A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.06A 1gfzA-5e84A:
undetectable
1gfzA-5e84A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.06A 1l5qA-5e84A:
undetectable
1l5qA-5e84A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.04A 1l5qB-5e84A:
undetectable
1l5qB-5e84A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.03A 1l7xA-5e84A:
undetectable
1l7xA-5e84A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.05A 1l7xB-5e84A:
undetectable
1l7xB-5e84A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 12 VAL A 342
ILE A 359
ILE A 356
PHE A 379
VAL A 345
LEU A 234
None
1.38A 1qhsA-5e84A:
undetectable
1qhsA-5e84A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 ILE A 371
GLY A 254
GLY A 227
LEU A 334
LEU A 253
None
None
ATP  A 801 (-3.8A)
None
None
1.09A 1rjdA-5e84A:
undetectable
1rjdA-5e84A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 ILE A 371
GLY A 254
GLY A 227
LEU A 334
LEU A 253
None
None
ATP  A 801 (-3.8A)
None
None
1.07A 1rjdB-5e84A:
undetectable
1rjdB-5e84A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 ILE A 371
GLY A 254
GLY A 227
LEU A 334
LEU A 253
None
None
ATP  A 801 (-3.8A)
None
None
1.06A 1rjdC-5e84A:
undetectable
1rjdC-5e84A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_B_ADNB1002_1
(CLASS B ACID
PHOSPHATASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 9 PHE A 612
LYS A 616
LEU A 601
TRP A 600
THR A 557
None
1.35A 2b82B-5e84A:
undetectable
2b82B-5e84A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 4 SER A 146
ASP A  94
ARG A 289
ASP A 259
None
None
None
ATP  A 801 ( 4.9A)
1.48A 2bm9C-5e84A:
undetectable
2bm9C-5e84A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_1
(PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.95A 2ieoA-5e84A:
undetectable
2ieoA-5e84A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.89A 2ieoB-5e84A:
undetectable
2ieoB-5e84A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASP A 224
VAL A 362
PRO A 173
THR A 171
ZN  A 806 (-2.7A)
None
ZN  A 806 ( 4.6A)
None
1.43A 2q6oB-5e84A:
undetectable
2q6oB-5e84A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASP A 186
ILE A 190
GLU A 533
TYR A 127
None
1.34A 2ya7C-5e84A:
undetectable
2ya7C-5e84A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 ALA A 179
THR A 102
GLY A 476
ARG A 528
LEU A 424
None
1.43A 3aobC-5e84A:
2.9
3aobC-5e84A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 7 GLY A 210
LYS A 213
ASP A 357
TYR A 209
None
1.34A 3arrA-5e84A:
undetectable
3arrA-5e84A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 5 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.11A 3bcrA-5e84A:
undetectable
3bcrA-5e84A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.86A 3cywA-5e84A:
undetectable
3cywA-5e84A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.90A 3d20B-5e84A:
undetectable
3d20B-5e84A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.07A 3dd1A-5e84A:
undetectable
3dd1A-5e84A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.06A 3dd1B-5e84A:
undetectable
3dd1B-5e84A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.06A 3ddsA-5e84A:
undetectable
3ddsA-5e84A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.04A 3ddsB-5e84A:
undetectable
3ddsB-5e84A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.08A 3ddwA-5e84A:
undetectable
3ddwA-5e84A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 6 ASN A 177
PHE A 176
ALA A 179
GLY A 100
None
1.06A 3ddwB-5e84A:
undetectable
3ddwB-5e84A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 11 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.89A 3ektD-5e84A:
undetectable
3ektD-5e84A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
3 / 3 CYH A  41
PRO A  63
ASP A 391
None
0.94A 3hlwB-5e84A:
undetectable
3hlwB-5e84A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 VAL A 345
ASP A 348
SER A 233
PRO A 421
LEU A 422
None
1.31A 3j6pB-5e84A:
undetectable
3j6pB-5e84A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.90A 3lzuA-5e84A:
undetectable
3lzuA-5e84A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 7 GLU A 201
LYS A  96
ASP A 231
ALA A 229
ZN  A 806 ( 2.6A)
ATP  A 801 (-2.3A)
ZN  A 806 (-2.8A)
ATP  A 801 (-4.1A)
1.17A 3mbgA-5e84A:
undetectable
3mbgB-5e84A:
undetectable
3mbgA-5e84A:
11.55
3mbgB-5e84A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.88A 3oxxA-5e84A:
undetectable
3oxxA-5e84A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 8 ASP A 224
GLY A 364
TYR A  39
GLU A 201
ZN  A 806 (-2.7A)
ATP  A 801 (-3.1A)
ATP  A 801 (-4.8A)
ZN  A 806 ( 2.6A)
0.88A 3s3mA-5e84A:
3.7
3s3mA-5e84A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 8 ASP A 224
GLY A 364
TYR A  39
GLU A 201
ZN  A 806 (-2.7A)
ATP  A 801 (-3.1A)
ATP  A 801 (-4.8A)
ZN  A 806 ( 2.6A)
0.90A 3s3nA-5e84A:
3.5
3s3nA-5e84A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.98A 3spkB-5e84A:
undetectable
3spkB-5e84A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 PHE A 544
ILE A 145
GLU A 547
GLU A 155
VAL A  92
None
1.41A 4a97A-5e84A:
2.7
4a97B-5e84A:
4.0
4a97A-5e84A:
19.60
4a97B-5e84A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
3 / 3 VAL A  66
GLY A  77
LYS A  81
None
0.52A 4k50I-5e84A:
undetectable
4k50I-5e84A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 ALA A 398
TYR A 396
PHE A  45
GLY A  43
THR A 411
None
1.36A 4mm4A-5e84A:
undetectable
4mm4A-5e84A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.87A 4njuA-5e84A:
undetectable
4njuA-5e84A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.87A 4njuC-5e84A:
undetectable
4njuC-5e84A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 GLU A 143
ILE A 534
GLY A 100
LYS A 123
ILE A  99
None
1.07A 4o1eA-5e84A:
undetectable
4o1eA-5e84A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 GLY A 216
ILE A 220
ASN A 219
GLY A 210
PHE A 242
None
1.24A 4obwA-5e84A:
undetectable
4obwA-5e84A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 ALA A 229
GLY A 228
GLY A 227
ASP A  94
GLY A 249
ATP  A 801 (-4.1A)
ATP  A 801 (-4.1A)
ATP  A 801 (-3.8A)
None
None
1.00A 4obwB-5e84A:
undetectable
4obwB-5e84A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 GLY A 216
ILE A 220
ASN A 219
GLY A 210
PHE A 242
None
1.22A 4obwC-5e84A:
undetectable
4obwC-5e84A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 GLY A 216
ILE A 220
ASN A 219
GLY A 210
PHE A 242
None
1.24A 4obwD-5e84A:
undetectable
4obwD-5e84A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
3 / 3 CYH A  41
PRO A  63
ASP A 391
None
0.93A 4pm5A-5e84A:
undetectable
4pm5A-5e84A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 7 GLU A 201
THR A  37
GLY A  36
THR A  38
ZN  A 806 ( 2.6A)
ATP  A 801 (-4.0A)
ATP  A 801 (-3.2A)
ATP  A 801 (-3.5A)
0.90A 4qwpB-5e84A:
2.2
4qwpB-5e84A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 4 VAL A  66
ALA A  67
ASN A  90
GLN A  83
None
1.42A 4zgfA-5e84A:
undetectable
4zgfA-5e84A:
12.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 10 GLY A 226
GLY A 254
GLU A 256
GLY A 364
SER A 365
ILE A 368
ATP  A 801 (-3.3A)
None
None
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.7A)
1.47A 5aqfA-5e84A:
48.2
5aqfA-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
9 / 10 GLY A 226
GLY A 255
LYS A 296
ARG A 297
SER A 300
GLY A 364
SER A 365
ARG A 367
ILE A 368
ATP  A 801 (-3.3A)
ATP  A 801 (-3.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-3.8A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
ATP  A 801 (-4.7A)
1.01A 5aqfA-5e84A:
48.2
5aqfA-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
10 / 10 GLY A 227
GLY A 255
GLU A 293
LYS A 296
ARG A 297
SER A 300
GLY A 364
SER A 365
ARG A 367
ILE A 368
ATP  A 801 (-3.8A)
ATP  A 801 (-3.5A)
ATP  A 801 (-2.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-3.8A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
ATP  A 801 (-4.7A)
0.54A 5aqfA-5e84A:
48.2
5aqfA-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 10 GLY A 254
GLY A 255
LYS A 296
SER A 300
SER A 365
ILE A 368
None
ATP  A 801 (-3.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.7A)
1.43A 5aqfA-5e84A:
48.2
5aqfA-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 10 GLY A 226
GLY A 254
GLU A 256
GLY A 364
SER A 365
ILE A 368
ATP  A 801 (-3.3A)
None
None
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.7A)
1.49A 5aqfC-5e84A:
48.2
5aqfC-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
9 / 10 GLY A 226
GLY A 255
LYS A 296
ARG A 297
SER A 300
GLY A 364
SER A 365
ARG A 367
ILE A 368
ATP  A 801 (-3.3A)
ATP  A 801 (-3.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-3.8A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
ATP  A 801 (-4.7A)
1.03A 5aqfC-5e84A:
48.2
5aqfC-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
10 / 10 GLY A 227
GLY A 255
GLU A 293
LYS A 296
ARG A 297
SER A 300
GLY A 364
SER A 365
ARG A 367
ILE A 368
ATP  A 801 (-3.8A)
ATP  A 801 (-3.5A)
ATP  A 801 (-2.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-3.8A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
ATP  A 801 (-4.7A)
0.55A 5aqfC-5e84A:
48.2
5aqfC-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 10 GLY A 227
GLY A 255
GLY A 364
SER A 365
ILE A 371
ATP  A 801 (-3.8A)
ATP  A 801 (-3.5A)
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
None
1.04A 5aqfC-5e84A:
48.2
5aqfC-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 10 GLY A 254
GLY A 255
LYS A 296
SER A 300
SER A 365
ILE A 368
None
ATP  A 801 (-3.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.7A)
1.43A 5aqfC-5e84A:
48.2
5aqfC-5e84A:
69.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 10 GLY A 226
GLY A 254
GLU A 256
GLY A 364
SER A 365
ILE A 368
ATP  A 801 (-3.3A)
None
None
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.7A)
1.43A 5aqyA-5e84A:
51.1
5aqyA-5e84A:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 10 GLY A 226
GLY A 254
GLY A 364
SER A 365
ARG A 367
ILE A 368
ATP  A 801 (-3.3A)
None
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
ATP  A 801 (-4.7A)
1.22A 5aqyA-5e84A:
51.1
5aqyA-5e84A:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
9 / 10 GLY A 226
GLY A 255
LYS A 296
ARG A 297
SER A 300
GLY A 364
SER A 365
ARG A 367
ILE A 368
ATP  A 801 (-3.3A)
ATP  A 801 (-3.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-3.8A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
ATP  A 801 (-4.7A)
0.99A 5aqyA-5e84A:
51.1
5aqyA-5e84A:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 10 GLY A 227
GLY A 254
GLY A 364
SER A 365
ARG A 367
ILE A 368
ATP  A 801 (-3.8A)
None
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
ATP  A 801 (-4.7A)
1.07A 5aqyA-5e84A:
51.1
5aqyA-5e84A:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
10 / 10 GLY A 227
GLY A 255
GLU A 293
LYS A 296
ARG A 297
SER A 300
GLY A 364
SER A 365
ARG A 367
ILE A 368
ATP  A 801 (-3.8A)
ATP  A 801 (-3.5A)
ATP  A 801 (-2.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-3.8A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.1A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.1A)
ATP  A 801 (-4.7A)
0.54A 5aqyA-5e84A:
51.1
5aqyA-5e84A:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
6 / 10 GLY A 254
GLY A 255
LYS A 296
SER A 300
SER A 365
ILE A 368
None
ATP  A 801 (-3.5A)
ATP  A 801 (-2.7A)
ATP  A 801 (-2.6A)
ATP  A 801 (-3.8A)
ATP  A 801 (-4.7A)
1.45A 5aqyA-5e84A:
51.1
5aqyA-5e84A:
48.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
3 / 3 ARG A 289
THR A  38
ASP A  94
None
ATP  A 801 (-3.5A)
None
0.91A 5g5gA-5e84A:
undetectable
5g5gB-5e84A:
undetectable
5g5gA-5e84A:
18.48
5g5gB-5e84A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 VAL A 345
ASP A 348
SER A 233
PRO A 421
LEU A 422
None
1.25A 5nd4B-5e84A:
undetectable
5nd4B-5e84A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 VAL A 345
ASP A 348
SER A 233
PRO A 421
LEU A 422
None
1.22A 5ogcB-5e84A:
undetectable
5ogcB-5e84A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_1
(SULFOTRANSFERASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 4 TYR A  39
ASP A 391
ASP A 259
SER A 365
ATP  A 801 (-4.8A)
None
ATP  A 801 ( 4.9A)
ATP  A 801 (-3.8A)
1.40A 5tiwA-5e84A:
0.0
5tiwA-5e84A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
4 / 5 THR A 508
GLU A 498
THR A 445
LEU A 424
None
1.35A 5utuH-5e84A:
2.0
5utuH-5e84A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 ILE A 199
VAL A 394
ALA A 204
PHE A 230
LEU A 253
None
1.37A 6a7pB-5e84A:
undetectable
6a7pB-5e84A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)
5e84 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo
sapiens)
5 / 12 LEU A  35
ASP A 391
VAL A 394
GLY A 226
PRO A 173
None
None
None
ATP  A 801 (-3.3A)
ZN  A 806 ( 4.6A)
0.86A 6dilA-5e84A:
undetectable
6dilA-5e84A:
12.24