SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e86'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5e86 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 646
GLN A 449
GLU A 494
ILE A 450
 None
 1.10A 2fcnA-5e86A:
undetectable
2fcnB-5e86A:
undetectable		 2fcnA-5e86A:
18.22
2fcnB-5e86A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 5e86 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 480
ASP A 511
GLY A 513
VAL A 457
ILE A 483
 None
 0.99A 3nu6B-5e86A:
undetectable		 3nu6B-5e86A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5e86 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 533
PRO A 531
ILE A 534
LEU A 529
 None
 1.15A 5m45A-5e86A:
undetectable		 5m45A-5e86A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5e86 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 533
PRO A 531
ILE A 534
LEU A 529
 None
 1.18A 5m45D-5e86A:
undetectable		 5m45D-5e86A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5e86 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 533
PRO A 531
ILE A 534
LEU A 529
 None
 1.14A 5m45G-5e86A:
undetectable		 5m45G-5e86A:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5e86 78 KDA
GLUCOSE-REGULATED
PROTEIN
(Homo
sapiens) 		4 / 4 GLU A 533
PRO A 531
ILE A 534
LEU A 529
 None
 1.20A 5m45J-5e86A:
undetectable		 5m45J-5e86A:
14.14