SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e8c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		5 / 12 LEU B  81
VAL B  80
SER B  79
SER B  21
VAL B  71
 None
 1.12A 1db1A-5e8cB:
undetectable		 1db1A-5e8cB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 5e8c UL31
UL34 PROTEIN
(Suid
alphaherpesvirus
1;
Suid
alphaherpesvirus
1) 		4 / 4 ALA A  37
ARG B   8
GLN A  38
GLU A  42
 None
 1.18A 1lqtB-5e8cA:
undetectable		 1lqtB-5e8cA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 5e8c UL31
UL34 PROTEIN
(Suid
alphaherpesvirus
1;
Suid
alphaherpesvirus
1) 		4 / 4 ALA A  37
ARG B   8
GLN A  38
GLU A  42
 None
 1.19A 1lquB-5e8cA:
undetectable		 1lquB-5e8cA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5e8c UL31
UL34 PROTEIN
(Suid
alphaherpesvirus
1;
Suid
alphaherpesvirus
1) 		4 / 8 ASP A  71
ASN A  72
SER B 140
ALA A  68
 None
 1.11A 1rqpC-5e8cA:
undetectable		 1rqpC-5e8cA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5e8c UL31
(Suid
alphaherpesvirus
1) 		4 / 7 ASP A 156
ARG A 160
VAL A 162
ARG A 155
 None
 1.03A 2yfbA-5e8cA:
undetectable		 2yfbA-5e8cA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5e8c UL31
(Suid
alphaherpesvirus
1) 		4 / 6 ASP A 156
ARG A 160
VAL A 162
ARG A 155
 None
 1.01A 2yfbB-5e8cA:
undetectable		 2yfbB-5e8cA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 5e8c UL31
(Suid
alphaherpesvirus
1) 		5 / 12 LEU A  65
LEU A 115
ILE A 118
VAL A 164
VAL A 180
 None
 1.13A 2ygnA-5e8cA:
undetectable		 2ygnA-5e8cA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5e8c UL31
(Suid
alphaherpesvirus
1) 		5 / 12 LEU A 125
PHE A 124
VAL A 128
LEU A 115
ALA A 236
 None
 0.98A 3mdvB-5e8cA:
undetectable		 3mdvB-5e8cA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_B_GAIB408_0
(PROTEIN (ARGINASE))		 5e8c UL31
(Suid
alphaherpesvirus
1) 		4 / 5 ARG A 220
HIS A 204
MET A 177
ASP A 169
 CL  A 301 (-4.6A)
None
None
None
 1.50A 4cevB-5e8cA:
undetectable
4cevC-5e8cA:
undetectable		 4cevB-5e8cA:
21.97
4cevC-5e8cA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF412_0
(PROTEIN (ARGINASE))		 5e8c UL31
(Suid
alphaherpesvirus
1) 		4 / 5 MET A 177
ASP A 169
ARG A 220
HIS A 204
 None
None
CL  A 301 (-4.6A)
None
 1.49A 4cevD-5e8cA:
undetectable
4cevF-5e8cA:
undetectable		 4cevD-5e8cA:
21.97
4cevF-5e8cA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5e8c UL31
(Suid
alphaherpesvirus
1) 		4 / 7 GLU A 251
GLU A 255
TYR A 256
ARG A 163
 None
 1.08A 4mi4B-5e8cA:
undetectable
4mi4C-5e8cA:
undetectable		 4mi4B-5e8cA:
22.89
4mi4C-5e8cA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5e8c UL31
(Suid
alphaherpesvirus
1) 		4 / 8 GLU A 251
GLU A 255
TYR A 256
ARG A 163
 None
 1.08A 4mj8B-5e8cA:
undetectable
4mj8C-5e8cA:
undetectable		 4mj8B-5e8cA:
21.46
4mj8C-5e8cA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		4 / 5 VAL B  55
VAL B  71
GLY B  84
PHE B  50
 None
 1.09A 5d4nA-5e8cB:
undetectable
5d4nC-5e8cB:
undetectable		 5d4nA-5e8cB:
19.57
5d4nC-5e8cB:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5e8c UL31
(Suid
alphaherpesvirus
1) 		5 / 10 LEU A  65
ALA A  68
LEU A  83
GLY A  86
HIS A 190
 None
None
None
ZN  A 300 ( 4.8A)
None
 1.41A 5dx3A-5e8cA:
undetectable		 5dx3A-5e8cA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		3 / 3 VAL B   6
GLN B  39
CYH B  20
 None
 0.66A 5icxA-5e8cB:
undetectable
5icxE-5e8cB:
undetectable		 5icxA-5e8cB:
21.46
5icxE-5e8cB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		3 / 3 VAL B   6
GLN B  39
CYH B  20
 None
 0.83A 5icxC-5e8cB:
undetectable
5icxF-5e8cB:
undetectable		 5icxC-5e8cB:
21.46
5icxF-5e8cB:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 5e8c UL31
(Suid
alphaherpesvirus
1) 		3 / 3 HIS A 188
HIS A 190
HIS A 191
 ZN  A 300 (-3.2A)
None
None
 0.52A 5oexA-5e8cA:
undetectable		 5oexA-5e8cA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		5 / 10 GLY B  84
VAL B  73
VAL B 139
VAL B  40
LEU B  52
 None
 1.16A 6czmA-5e8cB:
undetectable
6czmC-5e8cB:
undetectable		 6czmA-5e8cB:
20.99
6czmC-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		5 / 9 VAL B 139
VAL B  40
LEU B  52
GLY B  84
VAL B  73
 None
 1.19A 6czmA-5e8cB:
undetectable
6czmB-5e8cB:
undetectable		 6czmA-5e8cB:
20.99
6czmB-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		5 / 9 VAL B 139
VAL B  40
LEU B  52
GLY B  84
VAL B  73
 None
 1.18A 6czmB-5e8cB:
undetectable
6czmC-5e8cB:
undetectable		 6czmB-5e8cB:
20.99
6czmC-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		5 / 9 VAL B 139
VAL B  40
LEU B  52
GLY B  84
VAL B  73
 None
 1.15A 6czmD-5e8cB:
undetectable
6czmE-5e8cB:
undetectable		 6czmD-5e8cB:
20.99
6czmE-5e8cB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5e8c UL34 PROTEIN
(Suid
alphaherpesvirus
1) 		5 / 10 VAL B 139
VAL B  40
LEU B  52
GLY B  84
VAL B  73
 None
 1.17A 6czmE-5e8cB:
undetectable
6czmF-5e8cB:
undetectable		 6czmE-5e8cB:
20.99
6czmF-5e8cB:
20.99