SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5e8g FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR
(Homo
sapiens) 		4 / 8 TYR A 358
MET A 348
PHE A 360
LEU A 335
 None
 0.67A 3khmA-5e8gA:
undetectable		 3khmA-5e8gA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5e8g FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR
(Homo
sapiens) 		4 / 7 LEU A 339
TYR A 332
LEU A 287
TYR A 342
 None
 1.14A 4b3qA-5e8gA:
undetectable		 4b3qA-5e8gA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5e8g FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR
(Homo
sapiens) 		6 / 12 GLY A 322
GLN A 285
LEU A 287
LEU A 288
GLU A 289
LEU A 290
 None
 0.90A 5nwwA-5e8gA:
undetectable		 5nwwA-5e8gA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5e8g FRIEND LEUKEMIA
INTEGRATION 1
TRANSCRIPTION FACTOR
(Homo
sapiens) 		6 / 12 GLY A 322
LYS A 327
LEU A 287
LEU A 288
GLU A 289
LEU A 290
 None
 1.39A 5nwwA-5e8gA:
undetectable		 5nwwA-5e8gA:
14.84