SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e8h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLU A 198
ARG A 223
ARG A 219
GLU A 152
 None
 0.80A 1cmaA-5e8hA:
undetectable
1cmaB-5e8hA:
0.3		 1cmaA-5e8hA:
15.34
1cmaB-5e8hA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLU A 279
LEU A 227
ALA A 194
LEU A 190
 None
 0.87A 1hwiB-5e8hA:
undetectable		 1hwiB-5e8hA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLU A 279
LEU A 227
ALA A 194
LEU A 190
 None
 0.84A 1hwiC-5e8hA:
undetectable		 1hwiC-5e8hA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_A_RISA901_1
(GERANYLTRANSTRANSFER
ASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 SER A  88
LEU A  89
ASP A  98
ARG A 103
THR A 193
 None
 0.70A 1rqjA-5e8hA:
35.0		 1rqjA-5e8hA:
41.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RQJ_B_RISB903_1
(GERANYLTRANSTRANSFER
ASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 SER A  88
LEU A  89
ASP A  98
ARG A 103
THR A 193
 None
 0.70A 1rqjB-5e8hA:
34.8		 1rqjB-5e8hA:
41.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YQ7_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A  89
ASP A  92
ASP A  98
ARG A 103
THR A 193
 None
 1.12A 1yq7A-5e8hA:
23.1		 1yq7A-5e8hA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A  89
ASP A  92
ASP A  98
ARG A 103
THR A 193
 None
 0.94A 1yv5A-5e8hA:
23.2		 1yv5A-5e8hA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 HIS A 110
ASN A  99
THR A 108
PRO A 107
 None
 1.38A 2ez7A-5e8hA:
undetectable		 2ez7A-5e8hA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_A_RISA400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 LEU A  89
ASP A  92
ASP A  98
ARG A 103
THR A 193
 None
 1.05A 2o1oA-5e8hA:
22.8		 2o1oA-5e8hA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O1O_B_RISB400_1
(PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A  89
ASP A  92
ASP A  98
ARG A 103
THR A 193
 None
 1.20A 2o1oB-5e8hA:
23.1		 2o1oB-5e8hA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A  89
ASP A  92
ASP A  98
ARG A 103
THR A 193
 None
 1.27A 2q58A-5e8hA:
23.0		 2q58A-5e8hA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 VAL A 202
GLY A 204
LYS A 217
ARG A 219
 None
 0.90A 3bjwC-5e8hA:
undetectable		 3bjwC-5e8hA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 VAL A 202
GLY A 204
LYS A 217
ARG A 219
 None
 0.96A 3bjwA-5e8hA:
1.5		 3bjwA-5e8hA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 SER A 138
MET A 146
ASP A  70
 None
 0.90A 4mm4B-5e8hA:
undetectable		 4mm4B-5e8hA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A  89
ASP A  92
ARG A 103
GLN A 166
THR A 193
 None
 1.23A 4ng6A-5e8hA:
23.1		 4ng6A-5e8hA:
28.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 SER A  88
LEU A  89
ASP A  98
ARG A 103
 None
 0.38A 4umjA-5e8hA:
38.5		 4umjA-5e8hA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 LEU A  89
ASP A  92
ARG A 103
GLN A 166
THR A 193
 None
 1.20A 4umjB-5e8hA:
38.4		 4umjB-5e8hA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 SER A  88
LEU A  89
ASP A  98
ARG A 103
THR A 193
 None
 0.49A 4umjB-5e8hA:
38.4		 4umjB-5e8hA:
46.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 ILE A 215
ILE A 206
ARG A 145
LEU A 218
 None
 1.31A 5dzkh-5e8hA:
undetectable
5dzkn-5e8hA:
undetectable
5dzkv-5e8hA:
undetectable		 5dzkh-5e8hA:
21.34
5dzkn-5e8hA:
21.34
5dzkv-5e8hA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ILE A 157
THR A 134
VAL A 135
GLU A 131
 None
 1.17A 6fbvC-5e8hA:
undetectable		 6fbvC-5e8hA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 LEU A  89
ASP A  92
ARG A 103
GLN A 166
 None
 1.31A 6g31D-5e8hA:
20.4		 6g31D-5e8hA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A  89
ASP A  92
ARG A 103
GLN A 166
 None
 1.37A 6g31J-5e8hA:
20.9		 6g31J-5e8hA:
15.75