SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 8 GLU A 196
ARG A 221
ARG A 217
GLU A 151
 None
 0.62A 1cmaA-5e8kA:
undetectable
1cmaB-5e8kA:
1.2		 1cmaA-5e8kA:
15.33
1cmaB-5e8kA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 5 ARG A 217
ALA A 155
LYS A 154
GLU A 151
 None
 0.99A 1e7cA-5e8kA:
3.2		 1e7cA-5e8kA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 6 LEU A  90
LEU A  93
PRO A  94
MET A  96
 None
 1.09A 1hz4A-5e8kA:
4.8		 1hz4A-5e8kA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 GLU A  81
HIS A  84
ASP A  50
 None
 0.63A 1i9gA-5e8kA:
undetectable		 1i9gA-5e8kA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 11 LEU A 216
ALA A 220
ALA A  61
LEU A 296
VAL A  66
 None
 1.24A 1ictA-5e8kA:
undetectable
1ictC-5e8kA:
undetectable		 1ictA-5e8kA:
18.12
1ictC-5e8kA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 7 LEU A 195
PHE A  11
MET A  15
VAL A  16
 None
 0.97A 1wrlA-5e8kA:
undetectable
1wrlB-5e8kA:
undetectable		 1wrlA-5e8kA:
12.25
1wrlB-5e8kA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 LEU A  88
ASP A  91
ARG A 102
LYS A 190
THR A 191
 None
 1.35A 1yv5A-5e8kA:
22.5		 1yv5A-5e8kA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YV5_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 LEU A  88
ASP A  97
ARG A 102
LYS A 190
THR A 191
 None
 1.22A 1yv5A-5e8kA:
22.5		 1yv5A-5e8kA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 LEU A  88
ASP A  91
ARG A 102
LYS A 190
THR A 191
 None
 1.34A 2f8zF-5e8kA:
23.5		 2f8zF-5e8kA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8Z_F_ZOLF5001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 LEU A  88
ASP A  97
ARG A 102
LYS A 190
THR A 191
 None
 1.24A 2f8zF-5e8kA:
23.5		 2f8zF-5e8kA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F94_F_BFQF9001_1
(FARNESYL DIPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 LEU A  88
ASP A  97
ARG A 102
GLN A 163
THR A 191
 None
 0.94A 2f94F-5e8kA:
22.9		 2f94F-5e8kA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 6 LEU A 127
VAL A 200
MET A 201
ILE A  80
 None
 0.99A 2hyyC-5e8kA:
undetectable		 2hyyC-5e8kA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 ILE A 300
ALA A 297
ALA A 278
TYR A 219
LEU A  58
 None
 1.24A 2japA-5e8kA:
undetectable		 2japA-5e8kA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 ILE A 300
ALA A 297
ALA A 278
TYR A 219
LEU A  58
 None
 1.25A 2japB-5e8kA:
undetectable		 2japB-5e8kA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 ILE A 300
ALA A 297
ALA A 278
TYR A 219
LEU A  58
 None
 1.25A 2japC-5e8kA:
undetectable		 2japC-5e8kA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 ILE A 300
ALA A 297
ALA A 278
TYR A 219
LEU A  58
 None
 1.24A 2japD-5e8kA:
undetectable		 2japD-5e8kA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 5 VAL A 294
LEU A 293
ILE A 223
ALA A 278
 None
 0.92A 3n8yB-5e8kA:
undetectable		 3n8yB-5e8kA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 11 ILE A  80
ALA A 198
GLY A 224
HIS A  84
GLU A  81
 None
 1.27A 4j83A-5e8kA:
undetectable		 4j83A-5e8kA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPD_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 LEU A  88
ASP A  97
ARG A 102
LYS A 190
THR A 191
 None
 1.25A 4kpdA-5e8kA:
22.9		 4kpdA-5e8kA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KPJ_A_210A901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 9 LEU A  88
ASP A  97
ARG A 102
LYS A 190
THR A 191
 None
 1.25A 4kpjA-5e8kA:
22.6		 4kpjA-5e8kA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQS_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 LEU A  88
ASP A  97
ARG A 102
LYS A 190
THR A 191
 None
 1.25A 4kqsA-5e8kA:
22.9		 4kqsA-5e8kA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NG6_A_RISA405_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 12 LEU A  88
ASP A  97
ARG A 102
GLN A 163
THR A 191
 None
 1.00A 4ng6A-5e8kA:
22.5		 4ng6A-5e8kA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NUA_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 10 LEU A  88
ASP A  97
ARG A 102
LYS A 190
THR A 191
 None
 1.25A 4nuaA-5e8kA:
22.5		 4nuaA-5e8kA:
25.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 8 SER A  87
LEU A  88
ASP A  97
GLN A 163
 None
 0.74A 4umjA-5e8kA:
36.5		 4umjA-5e8kA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UMJ_B_BFQB1294_1
(GERANYLTRANSTRANSFER
ASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		5 / 9 SER A  87
LEU A  88
ASP A  97
GLN A 163
THR A 191
 None
 1.03A 4umjB-5e8kA:
36.4		 4umjB-5e8kA:
42.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		3 / 3 GLU A  81
HIS A  84
ASP A  50
 None
 0.68A 5c0oG-5e8kA:
undetectable		 5c0oG-5e8kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_D_ZOLD401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL
(Arabidopsis
thaliana) 		4 / 7 LEU A  88
ASP A  97
ARG A 102
GLN A 163
 None
 1.26A 6g31D-5e8kA:
20.2		 6g31D-5e8kA:
12.13