SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e9c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)
5e9c HEPARANASE
(Homo
sapiens)
4 / 8 LEU A 366
PHE A 363
ASP A 403
LEU A 406
None
1.09A 1e7cA-5e9cA:
undetectable
1e7cA-5e9cA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)
5e9c HEPARANASE
(Homo
sapiens)
5 / 11 VAL A 293
ILE A 377
GLU A 221
VAL A 323
PHE A 327
None
1.28A 1gx9A-5e9cA:
undetectable
1gx9A-5e9cA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)
5e9c HEPARANASE
(Homo
sapiens)
4 / 6 SER A 490
THR A 358
LEU A 406
ASP A 403
None
0.95A 1mxdA-5e9cA:
4.3
1mxdA-5e9cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)
5e9c HEPARANASE
(Homo
sapiens)
4 / 8 SER A 490
THR A 358
LEU A 406
ASP A 403
None
0.96A 1mxgA-5e9cA:
4.4
1mxgA-5e9cA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)
5e9c HEPARANASE
(Homo
sapiens)
5 / 11 LEU A 173
ILE A 218
PHE A 258
GLY A 215
LYS A 214
None
1.30A 2bxmA-5e9cA:
undetectable
2bxmA-5e9cA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)
5e9c HEPARANASE
(Homo
sapiens)
5 / 12 ALA A 347
GLY A 351
ASN A 390
ALA A 305
ASP A 357
None
1.16A 2c49A-5e9cA:
undetectable
2c49A-5e9cA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
5e9c HEPARANASE
(Homo
sapiens)
4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
None
1.08A 2dysP-5e9cA:
undetectable
2dysW-5e9cA:
undetectable
2dysP-5e9cA:
21.23
2dysW-5e9cA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
5e9c HEPARANASE
(Homo
sapiens)
4 / 6 LEU A 495
GLN A 494
LEU A 409
PHE A 531
None
1.01A 2einP-5e9cA:
undetectable
2einW-5e9cA:
undetectable
2einP-5e9cA:
21.23
2einW-5e9cA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)
5e9c HEPARANASE
(Homo
sapiens)
5 / 12 ASP A 357
GLY A 362
LEU A 366
LEU A 355
SER A 356
None
1.24A 2nv4B-5e9cA:
undetectable
2nv4B-5e9cA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)
5e9c HEPARANASE
(Homo
sapiens)
5 / 12 ASN A 224
GLU A 225
HIS A 296
TYR A 298
GLU A 343
IDR  A 606 (-3.2A)
5KV  A 608 (-2.8A)
None
IDR  A 606 (-4.4A)
IDR  A 606 (-2.4A)
0.60A 2v3dA-5e9cA:
5.9
2v3dA-5e9cA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)
5e9c HEPARANASE
(Homo
sapiens)
3 / 3 GLU A 225
GLY A 269
SER A 228
5KV  A 608 (-2.8A)
5KV  A 608 (-3.5A)
None
0.52A 4b53B-5e9cA:
undetectable
4b53B-5e9cA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
5e9c HEPARANASE
(Homo
sapiens)
5 / 12 PHE A 363
LEU A 311
ALA A 360
LEU A 479
LEU A 524
None
1.08A 5ljeA-5e9cA:
undetectable
5ljeA-5e9cA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5e9c HEPARANASE
(Homo
sapiens)
4 / 7 LEU A 495
GLN A 494
LEU A 409
PHE A 531
None
0.96A 5zcqP-5e9cA:
undetectable
5zcqW-5e9cA:
undetectable
5zcqP-5e9cA:
21.23
5zcqW-5e9cA:
7.81