SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e9g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 12 ALA A 201
PRO A 173
THR A 102
VAL A 136
LEU A  72
 None
 1.22A 1cbrA-5e9gA:
undetectable		 1cbrA-5e9gA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 12 ALA A 201
PRO A 173
THR A 102
VAL A 136
LEU A  72
 None
 1.22A 1cbrB-5e9gA:
undetectable		 1cbrB-5e9gA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 6 GLN A 166
ASP A 507
VAL A 509
GLY A 505
 None
 1.20A 1ekjC-5e9gA:
undetectable
1ekjD-5e9gA:
undetectable		 1ekjC-5e9gA:
17.76
1ekjD-5e9gA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 6 ASP A 507
VAL A 509
GLY A 505
GLN A 166
 None
 1.18A 1ekjC-5e9gA:
undetectable
1ekjD-5e9gA:
undetectable		 1ekjC-5e9gA:
17.76
1ekjD-5e9gA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 5 THR A 186
LEU A 191
GLY A 183
TYR A 129
 None
 1.09A 1gtiF-5e9gA:
undetectable		 1gtiF-5e9gA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		3 / 3 ARG A 316
GLY A 384
ASP A 386
 None
 0.54A 1kf6A-5e9gA:
undetectable
1kf6B-5e9gA:
undetectable		 1kf6A-5e9gA:
21.07
1kf6B-5e9gA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_B_ADNB501_1
(HYPOTHETICAL PROTEIN
PH0463)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 11 ASP A 269
ARG A 268
ILE A 261
PRO A 225
ASN A 231
 None
 1.48A 1wu8B-5e9gA:
0.0
1wu8C-5e9gA:
0.0		 1wu8B-5e9gA:
19.78
1wu8C-5e9gA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		3 / 3 THR A  91
GLU A 501
HIS A 511
 None
 0.81A 1xwfA-5e9gA:
undetectable		 1xwfA-5e9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		3 / 3 THR A  91
GLU A 501
HIS A 511
 None
 0.83A 1xwfB-5e9gA:
undetectable		 1xwfB-5e9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		3 / 3 THR A  91
GLU A 501
HIS A 511
 None
 0.88A 1xwfC-5e9gA:
undetectable		 1xwfC-5e9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		3 / 3 THR A  91
GLU A 501
HIS A 511
 None
 0.84A 1xwfD-5e9gA:
undetectable		 1xwfD-5e9gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 7 PHE A 317
ALA A 357
ASP A 318
TYR A 341
 None
 1.26A 2e5dA-5e9gA:
undetectable
2e5dB-5e9gA:
4.0		 2e5dA-5e9gA:
20.85
2e5dB-5e9gA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 7 ASP A 318
TYR A 341
PHE A 317
ALA A 357
 None
 1.27A 2e5dA-5e9gA:
4.0
2e5dB-5e9gA:
4.2		 2e5dA-5e9gA:
20.85
2e5dB-5e9gA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 12 SER A  65
SER A  61
ALA A 240
ASP A 241
ARG A  41
 None
 1.39A 2qm9A-5e9gA:
undetectable		 2qm9A-5e9gA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 10 TYR A 395
ALA A 396
ALA A 251
ALA A 399
TYR A 398
 None
 1.37A 2r2vC-5e9gA:
undetectable
2r2vF-5e9gA:
undetectable
2r2vG-5e9gA:
undetectable		 2r2vC-5e9gA:
5.50
2r2vF-5e9gA:
5.50
2r2vG-5e9gA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 12 GLY A 181
GLY A 184
LEU A 185
LEU A 247
ALA A 187
 None
 1.09A 3av6A-5e9gA:
undetectable		 3av6A-5e9gA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 7 TRP A 403
ASP A 254
SER A 435
THR A 467
 None
None
GOL  A 602 (-2.6A)
GOL  A 602 ( 3.0A)
 1.15A 3dzgB-5e9gA:
undetectable		 3dzgB-5e9gA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 6 SER A 110
ASP A 179
TYR A 127
PRO A 122
 None
MG  A 603 ( 4.9A)
None
None
 1.49A 3jqaC-5e9gA:
3.0		 3jqaC-5e9gA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 6 SER A 110
ASP A 179
TYR A 127
PRO A 122
 None
MG  A 603 ( 4.9A)
None
None
 1.50A 3jqaD-5e9gA:
2.6		 3jqaD-5e9gA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 11 ASP A 323
ASN A 326
VAL A 362
ALA A 357
ILE A 365
 None
 1.25A 3n23A-5e9gA:
undetectable		 3n23A-5e9gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_A_NIOA311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 9 ASP A 177
LEU A 191
ASP A 179
HIS A 182
ALA A 176
 MG  A 603 ( 2.7A)
None
MG  A 603 ( 4.9A)
None
None
 1.29A 3r2jA-5e9gA:
undetectable		 3r2jA-5e9gA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 11 ASP A 177
LEU A 191
ASP A 179
HIS A 182
ALA A 176
 MG  A 603 ( 2.7A)
None
MG  A 603 ( 4.9A)
None
None
 1.30A 3r2jB-5e9gA:
undetectable		 3r2jB-5e9gA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 12 ASP A 177
LEU A 191
ASP A 179
HIS A 182
ALA A 176
 MG  A 603 ( 2.7A)
None
MG  A 603 ( 4.9A)
None
None
 1.29A 3r2jC-5e9gA:
undetectable		 3r2jC-5e9gA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 11 ASP A 177
LEU A 191
ASP A 179
HIS A 182
ALA A 176
 MG  A 603 ( 2.7A)
None
MG  A 603 ( 4.9A)
None
None
 1.31A 3r2jD-5e9gA:
undetectable		 3r2jD-5e9gA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 4 LYS A 382
PHE A 272
PHE A 317
VAL A 321
 None
 1.34A 3rv5A-5e9gA:
0.2
3rv5B-5e9gA:
1.2		 3rv5A-5e9gA:
8.99
3rv5B-5e9gA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 12 GLY A 199
SER A  61
ILE A 174
ALA A 176
VAL A 105
 None
 1.20A 4dx5B-5e9gA:
undetectable		 4dx5B-5e9gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		3 / 3 ASP A 179
TRP A 463
SER A 110
 MG  A 603 ( 4.9A)
None
None
 1.05A 4lrhA-5e9gA:
undetectable		 4lrhA-5e9gA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 6 VAL A 136
LEU A 247
ILE A 203
ALA A 176
 None
 0.71A 4zf8A-5e9gA:
undetectable		 4zf8A-5e9gA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 7 PHE A  43
ARG A  41
ASP A 241
ILE A  48
 None
 1.38A 5a06B-5e9gA:
undetectable		 5a06B-5e9gA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		4 / 5 ALA A 125
HIS A 204
ALA A 178
GLU A 206
 None
GLV  A 601 (-4.6A)
None
MG  A 603 ( 4.7A)
 1.15A 5a06C-5e9gA:
undetectable
5a06D-5e9gA:
undetectable		 5a06C-5e9gA:
19.46
5a06D-5e9gA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 10 ALA A 423
ILE A 389
ALA A 392
ILE A 393
ILE A 402
 None
 0.99A 5mvmD-5e9gA:
undetectable
5mvmE-5e9gA:
undetectable		 5mvmD-5e9gA:
10.43
5mvmE-5e9gA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 5e9g ISOCITRATE LYASE
(Magnaporthe
oryzae) 		5 / 9 ALA A 251
ALA A 401
LEU A  68
CYH A 462
LEU A 247
 None
 1.43A 6ay6A-5e9gA:
undetectable		 6ay6A-5e9gA:
22.63