SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e9h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 ALA A 201
PRO A 173
THR A 102
VAL A 136
LEU A  72
 None
 1.23A 1cbrA-5e9hA:
undetectable		 1cbrA-5e9hA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 ALA A 201
PRO A 173
THR A 102
VAL A 136
LEU A  72
 None
 1.23A 1cbrB-5e9hA:
undetectable		 1cbrB-5e9hA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		4 / 7 THR A 186
LEU A 191
GLY A 183
TYR A 129
 None
 1.05A 1gtiD-5e9hA:
undetectable		 1gtiD-5e9hA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		4 / 5 THR A 186
LEU A 191
GLY A 183
TYR A 129
 None
 1.04A 1gtiF-5e9hA:
undetectable		 1gtiF-5e9hA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 11 LEU A 281
ALA A 293
ALA A 291
MET A 288
LEU A 284
 None
 1.34A 1hbpA-5e9hA:
undetectable		 1hbpA-5e9hA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 LEU A 281
ALA A 293
ALA A 291
MET A 288
LEU A 284
 None
 1.38A 1kt5A-5e9hA:
undetectable		 1kt5A-5e9hA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 10 ASP A 126
SER A 110
SER A 115
ALA A 116
ASP A 123
 None
None
None
None
MN  A 601 ( 4.0A)
 1.47A 1m4dA-5e9hA:
1.5		 1m4dA-5e9hA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		3 / 3 THR A  91
GLU A 500
HIS A 510
 None
 0.77A 1xwfA-5e9hA:
2.4		 1xwfA-5e9hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		3 / 3 THR A  91
GLU A 500
HIS A 510
 None
 0.77A 1xwfB-5e9hA:
undetectable		 1xwfB-5e9hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		3 / 3 THR A  91
GLU A 500
HIS A 510
 None
 0.81A 1xwfC-5e9hA:
2.6		 1xwfC-5e9hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		3 / 3 THR A  91
GLU A 500
HIS A 510
 None
 0.78A 1xwfD-5e9hA:
undetectable		 1xwfD-5e9hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 GLY A 181
GLY A 184
LEU A 185
LEU A 247
ALA A 187
 None
 1.03A 3av6A-5e9hA:
undetectable		 3av6A-5e9hA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		4 / 7 TRP A 402
ASP A 254
SER A 434
THR A 466
 None
None
MLI  A 602 (-2.8A)
MLI  A 602 (-2.9A)
 1.08A 3dzgB-5e9hA:
2.4		 3dzgB-5e9hA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		4 / 6 SER A 110
ASP A 179
TYR A 127
PRO A 122
 None
 1.50A 3jqaC-5e9hA:
undetectable		 3jqaC-5e9hA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 SER A 329
PHE A 330
ALA A 327
ALA A 324
ASP A 326
 None
 1.11A 3keeA-5e9hA:
undetectable		 3keeA-5e9hA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		3 / 3 TYR A 104
ASP A 179
ASP A 126
 None
 0.93A 3ou6B-5e9hA:
undetectable		 3ou6B-5e9hA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_A_NIOA311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 9 ASP A 177
LEU A 191
ASP A 179
HIS A 182
ALA A 176
 MN  A 601 (-2.9A)
None
None
None
None
 1.31A 3r2jA-5e9hA:
undetectable		 3r2jA-5e9hA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 11 ASP A 177
LEU A 191
ASP A 179
HIS A 182
ALA A 176
 MN  A 601 (-2.9A)
None
None
None
None
 1.33A 3r2jB-5e9hA:
undetectable		 3r2jB-5e9hA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 ASP A 177
LEU A 191
ASP A 179
HIS A 182
ALA A 176
 MN  A 601 (-2.9A)
None
None
None
None
 1.32A 3r2jC-5e9hA:
undetectable		 3r2jC-5e9hA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 11 ASP A 177
LEU A 191
ASP A 179
HIS A 182
ALA A 176
 MN  A 601 (-2.9A)
None
None
None
None
 1.35A 3r2jD-5e9hA:
2.2		 3r2jD-5e9hA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 ALA A 142
LEU A 144
GLY A 137
HIS A 138
ALA A 176
 None
 1.17A 3tm4A-5e9hA:
undetectable		 3tm4A-5e9hA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 ALA A 142
LEU A 144
GLY A 137
HIS A 138
ALA A 176
 None
 1.23A 3tm4B-5e9hA:
undetectable		 3tm4B-5e9hA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		3 / 3 ASP A 179
TRP A 462
SER A 110
 None
 1.06A 4lrhA-5e9hA:
undetectable		 4lrhA-5e9hA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		4 / 6 VAL A 136
LEU A 247
ILE A 203
ALA A 176
 None
 0.74A 4zf8A-5e9hA:
undetectable		 4zf8A-5e9hA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		4 / 5 ALA A 125
HIS A 204
ALA A 178
GLU A 206
 None
 1.06A 5a06C-5e9hA:
undetectable
5a06D-5e9hA:
2.9		 5a06C-5e9hA:
21.48
5a06D-5e9hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		5 / 12 PHE A 437
LEU A 433
ILE A 401
ARG A 454
TYR A 451
 None
 1.39A 5dlvA-5e9hA:
undetectable		 5dlvA-5e9hA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5e9h ISOCITRATE LYASE
(Fusarium
graminearum) 		3 / 3 THR A 130
ALA A 116
ASN A 134
 None
 0.61A 5ersA-5e9hA:
undetectable		 5ersA-5e9hA:
22.30