SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 CYH A 287
PHE A 375
SER A 290
LEU A 183
 None
 1.10A 1qcaA-5e9jA:
undetectable		 1qcaA-5e9jA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		10 / 12 LYS A 180
GLY A 205
GLY A 207
ILE A 228
ALA A 229
ASP A 261
SER A 262
GLN A 284
PHE A 285
TYR A 289
 SAH  A 501 (-2.3A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.8A)
SAH  A 501 ( 4.2A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
None
None
SAH  A 501 (-4.0A)
 0.52A 1ri4A-5e9jA:
31.7		 1ri4A-5e9jA:
32.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 MET A 179
VAL A 182
LEU A 183
PHE A 187
 None
 0.91A 1x8vA-5e9jA:
undetectable		 1x8vA-5e9jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A 372
GLU A 323
ILE A 430
PRO A 319
 None
 1.10A 2fcnA-5e9jA:
undetectable
2fcnB-5e9jA:
undetectable		 2fcnA-5e9jA:
14.29
2fcnB-5e9jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ILE A 228
ASP A 261
TYR A 289
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.8A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
 0.80A 2qe6A-5e9jA:
14.9		 2qe6A-5e9jA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ILE A 228
ASP A 261
TYR A 289
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.8A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.0A)
 0.62A 2qe6B-5e9jA:
15.2		 2qe6B-5e9jA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A 418
TYR A 171
SER A 419
 None
 0.75A 2xatA-5e9jA:
undetectable		 2xatA-5e9jA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A 391
GLU A 401
ASN A 405
 None
 0.83A 2y7hC-5e9jA:
9.4		 2y7hC-5e9jA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ASP A 203
LEU A 204
GLY A 205
ASP A 227
SER A 262
 SAH  A 501 ( 4.3A)
None
SAH  A 501 (-3.4A)
SAH  A 501 (-2.5A)
SAH  A 501 (-4.0A)
 1.02A 3cjtC-5e9jA:
13.0		 3cjtC-5e9jA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 9 ILE A 280
TYR A 313
ILE A 315
LEU A 183
GLU A 186
 None
 1.26A 3f78A-5e9jA:
undetectable		 3f78A-5e9jA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 CYH A 281
PHE A 436
PHE A 434
TYR A 385
 None
 1.19A 3hggA-5e9jA:
undetectable		 3hggA-5e9jA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ASP A 261
VAL A 286
TYR A 289
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.2A)
SAH  A 501 (-4.0A)
 0.65A 3o7wA-5e9jA:
14.4		 3o7wA-5e9jA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A 207
ASP A 227
ASP A 261
 SAH  A 501 (-3.4A)
SAH  A 501 (-2.5A)
SAH  A 501 (-3.5A)
 0.41A 3ou7C-5e9jA:
14.2		 3ou7C-5e9jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 TYR A 385
MET A 276
LEU A 202
 None
 1.00A 3vw1D-5e9jA:
undetectable		 3vw1D-5e9jA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 9 GLY A 209
GLY A 210
ASN A 177
SER A 232
GLY A 207
 None
None
None
SAH  A 501 ( 4.6A)
SAH  A 501 (-3.4A)
 1.30A 3ztvA-5e9jA:
undetectable		 3ztvA-5e9jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ASP A 227
ILE A 228
ASP A 261
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-2.5A)
SAH  A 501 (-3.8A)
SAH  A 501 (-3.5A)
 0.38A 4iv8A-5e9jA:
16.1		 4iv8A-5e9jA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ASP A 227
ILE A 228
ASP A 261
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-2.5A)
SAH  A 501 (-3.8A)
SAH  A 501 (-3.5A)
 0.38A 4iv8B-5e9jA:
16.0		 4iv8B-5e9jA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ILE A 228
ALA A 229
PHE A 285
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.8A)
SAH  A 501 ( 4.2A)
None
 1.24A 4kicA-5e9jA:
14.2		 4kicA-5e9jA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A 360
ILE A 430
PHE A 336
ASN A 338
 None
 1.39A 4o7gA-5e9jA:
undetectable
4o7gB-5e9jA:
undetectable		 4o7gA-5e9jA:
21.38
4o7gB-5e9jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 CYH A 283
MET A 300
ASN A 303
 None
 1.23A 5qh8A-5e9jA:
undetectable		 5qh8A-5e9jA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 GLY A 205
GLY A 207
ASP A 211
ILE A 228
SER A 262
VAL A 286
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-4.2A)
 0.60A 6ectA-5e9jA:
14.3		 6ectA-5e9jA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 GLY A 185
PHE A 187
VAL A 191
SER A 282
 None
 1.00A 6hu9S-5e9jA:
undetectable
6hu9q-5e9jA:
undetectable		 6hu9S-5e9jA:
18.40
6hu9q-5e9jA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 8 LYS A 217
GLY A 218
GLY A 185
LEU A 188
 None
 0.86A 6mdqA-5e9jA:
undetectable		 6mdqA-5e9jA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ASP A 203
GLY A 205
GLY A 207
ALA A 229
ASP A 261
 SAH  A 501 ( 4.3A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 ( 4.2A)
SAH  A 501 (-3.5A)
 0.77A 6nj9K-5e9jA:
9.8		 6nj9K-5e9jA:
20.38