SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e9o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_A_ZPCA1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5e9o	CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X (Spirochaeta thermophila)	4 / 7	TYR A 526 ILE A 517 ASN A 503 GLU A 461	None	0.89A	4a97E-5e9oA: undetectable	4a97E-5e9oA: 14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_D_ZPCD1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5e9o	CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X (Spirochaeta thermophila)	4 / 8	TYR A 526 ILE A 517 ASN A 503 GLU A 461	None	0.90A	4a97C-5e9oA: undetectable	4a97C-5e9oA: 14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_H_ZPCH1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5e9o	CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X (Spirochaeta thermophila)	4 / 8	TYR A 526 ILE A 517 ASN A 503 GLU A 461	None	0.89A	4a97G-5e9oA: undetectable	4a97G-5e9oA: 14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_I_ZPCI1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5e9o	CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X (Spirochaeta thermophila)	4 / 7	TYR A 526 ILE A 517 ASN A 503 GLU A 461	None	1.10A	4a97H-5e9oA: undetectable	4a97H-5e9oA: 14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_J_ZPCJ1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5e9o	CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X (Spirochaeta thermophila)	4 / 8	TYR A 526 ILE A 517 ASN A 503 GLU A 461	None	1.01A	4a97I-5e9oA: undetectable	4a97I-5e9oA: 14.19

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A97_A_ZPCA1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5e9o","CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X","Spirochaeta thermophila",4,"TYR A 526;ILE A 517;ASN A 503;GLU A 461","None","0.89A","4a97E-5e9oA:undetectable","4a97E-5e9oA:14.19"],["4A97_D_ZPCD1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5e9o","CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X","Spirochaeta thermophila",4,"TYR A 526;ILE A 517;ASN A 503;GLU A 461","None","0.90A","4a97C-5e9oA:undetectable","4a97C-5e9oA:14.19"],["4A97_H_ZPCH1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5e9o","CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X","Spirochaeta thermophila",4,"TYR A 526;ILE A 517;ASN A 503;GLU A 461","None","0.89A","4a97G-5e9oA:undetectable","4a97G-5e9oA:14.19"],["4A97_I_ZPCI1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5e9o","CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X","Spirochaeta thermophila",4,"TYR A 526;ILE A 517;ASN A 503;GLU A 461","None","1.10A","4a97H-5e9oA:undetectable","4a97H-5e9oA:14.19"],["4A97_J_ZPCJ1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5e9o","CELLULASE, GLYCOSYL HYDROLASE FAMILY 5, TPS LINKER, DOMAIN X","Spirochaeta thermophila",4,"TYR A 526;ILE A 517;ASN A 503;GLU A 461","None","1.01A","4a97I-5e9oA:undetectable","4a97I-5e9oA:14.19"]]