SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 ILE A 356
ALA A 341
LEU A 338
LEU A 396
ILE A 461
 None
 0.98A 1bsxA-5e9uA:
undetectable		 1bsxA-5e9uA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 ILE A 356
ALA A 341
LEU A 338
LEU A 396
ILE A 461
 None
 0.98A 1bsxB-5e9uA:
undetectable		 1bsxB-5e9uA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 VAL A 414
GLY A 415
LEU A 308
PHE A 432
VAL A 489
 None
 0.97A 1fduC-5e9uA:
7.0		 1fduC-5e9uA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 ILE A 217
LEU A 496
LEU A 497
HIS A 242
ILE A 303
 None
None
None
NAG  A 602 (-3.6A)
None
 1.22A 1fmlB-5e9uA:
undetectable		 1fmlB-5e9uA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 7 TYR A 187
VAL A 227
ILE A 224
GLU A 184
 None
 1.01A 1j96B-5e9uA:
undetectable		 1j96B-5e9uA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 VAL A 305
ALA A 413
LEU A 410
VAL A 480
ALA A 481
 NAG  A 602 ( 4.7A)
None
None
None
None
 1.02A 1sa1A-5e9uA:
4.7
1sa1B-5e9uA:
4.7		 1sa1A-5e9uA:
21.28
1sa1B-5e9uA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		4 / 5 ALA B 370
TYR B 389
ILE B 377
ASP B 386
 None
 0.99A 1upfA-5e9uB:
undetectable		 1upfA-5e9uB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		4 / 5 ALA B 370
TYR B 389
ILE B 377
ASP B 386
 None
 1.01A 1upfC-5e9uB:
undetectable		 1upfC-5e9uB:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 10 LEU B 355
LEU B 378
ILE B 353
GLU B 410
LEU B 408
 None
 1.20A 1wopA-5e9uB:
undetectable		 1wopA-5e9uB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		4 / 6 SER B  43
ARG B 176
PHE B 179
ILE B 161
 None
 1.16A 2qeiA-5e9uB:
undetectable		 2qeiA-5e9uB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 7 ILE A 276
GLN A 265
ARG A  24
ASP A 219
 None
 0.97A 2qqcB-5e9uA:
undetectable
2qqcC-5e9uA:
undetectable		 2qqcB-5e9uA:
11.75
2qqcC-5e9uA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 7 ASP A 219
ILE A 276
GLN A 265
ARG A  24
 None
 0.94A 2qqcA-5e9uA:
undetectable
2qqcF-5e9uA:
undetectable		 2qqcA-5e9uA:
7.36
2qqcF-5e9uA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 7 ASP A 219
ILE A 276
GLN A 265
ARG A  24
 None
 1.01A 2qqcG-5e9uA:
undetectable
2qqcJ-5e9uA:
undetectable		 2qqcG-5e9uA:
7.36
2qqcJ-5e9uA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 7 ASP A 219
ILE A 276
GLN A 265
ARG A  24
 None
 0.95A 2qqcI-5e9uA:
undetectable
2qqcL-5e9uA:
undetectable		 2qqcI-5e9uA:
7.36
2qqcL-5e9uA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 TYR A 391
GLY A 415
SER A 416
LEU A 418
LEU A 308
 None
 1.20A 3e23A-5e9uA:
undetectable		 3e23A-5e9uA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 12 ASP B   6
SER B 198
SER B 202
TYR B 201
VAL B 177
 None
 1.29A 3mbhC-5e9uB:
3.4		 3mbhC-5e9uB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 12 ASP B   6
SER B 198
SER B 202
TYR B 201
VAL B 177
 None
 1.28A 3mbhD-5e9uB:
3.5		 3mbhD-5e9uB:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		3 / 3 GLN B 244
THR B 243
LEU B 441
 None
 0.72A 3ondA-5e9uB:
4.2		 3ondA-5e9uB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		3 / 3 GLN B 244
THR B 243
LEU B 441
 None
 0.71A 3ondB-5e9uB:
4.2		 3ondB-5e9uB:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 10 ALA A 301
GLY A 238
VAL A 239
VAL A 305
ILE A 303
 None
None
None
NAG  A 602 ( 4.7A)
None
 1.10A 3oxvB-5e9uA:
undetectable		 3oxvB-5e9uA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 11 ALA A 301
GLY A 238
VAL A 239
VAL A 305
ILE A 303
 None
None
None
NAG  A 602 ( 4.7A)
None
 1.08A 3oxvD-5e9uA:
undetectable		 3oxvD-5e9uA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 9 LEU A 420
LEU A 410
THR A 325
LEU A 338
SER A 401
 None
 1.48A 3q1eB-5e9uA:
undetectable
3q1eD-5e9uA:
undetectable		 3q1eB-5e9uA:
12.23
3q1eD-5e9uA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 8 ASP A 110
GLY A 134
PRO A 107
ARG A 103
 None
 0.80A 3s3nA-5e9uA:
undetectable		 3s3nA-5e9uA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 10 ILE B  31
VAL B  30
TYR B   8
SER B  43
TYR B  45
 None
 1.44A 3uprA-5e9uB:
undetectable		 3uprA-5e9uB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 10 ILE B  31
VAL B  30
TYR B   8
SER B  43
TYR B  45
 None
 1.44A 3uprC-5e9uB:
undetectable		 3uprC-5e9uB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 9 ALA B 424
ARG B 427
GLY B 426
ASN B 430
ILE B 377
 None
 1.33A 3wdmA-5e9uB:
4.9		 3wdmA-5e9uB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 8 TYR A 147
TYR A 141
TRP A  64
MET A  42
 None
 1.42A 3wipD-5e9uA:
undetectable
3wipE-5e9uA:
undetectable		 3wipD-5e9uA:
17.53
3wipE-5e9uA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 7 ARG A 328
GLY A  16
ASN A   7
GLU A  18
 None
UDP  A 601 (-3.1A)
None
None
 0.90A 4g0vA-5e9uA:
undetectable		 4g0vA-5e9uA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 6 ARG A 328
GLY A  16
ASN A   7
GLU A  18
 None
UDP  A 601 (-3.1A)
None
None
 0.87A 4g0vB-5e9uA:
2.6		 4g0vB-5e9uA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 ILE A 379
ALA A 375
ALA A 345
LEU A 398
ILE A 461
 None
 1.16A 4lnxA-5e9uA:
undetectable		 4lnxA-5e9uA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		3 / 3 TRP A 493
GLN A  32
THR A 494
 None
 0.97A 4m2xA-5e9uA:
undetectable		 4m2xA-5e9uA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 12 TYR B 354
GLY B 379
ILE B 297
ASN B 358
GLY B 299
 None
 1.21A 4obwD-5e9uB:
undetectable		 4obwD-5e9uB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5e9u GLYCOSYLTRANSFERASE
GTF1
GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii;
Streptococcus
gordonii) 		4 / 7 LYS B 129
LEU B 116
GLU B 118
ILE A 193
 None
 1.19A 4tvtA-5e9uB:
undetectable		 4tvtA-5e9uB:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 6 TYR A  68
TYR A 203
LEU A 200
PHE A 189
 None
 1.26A 4twdB-5e9uA:
undetectable
4twdC-5e9uA:
undetectable		 4twdB-5e9uA:
20.66
4twdC-5e9uA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 6 TYR A  68
TYR A 203
LEU A 200
PHE A 189
 None
 1.26A 4twdD-5e9uA:
undetectable
4twdE-5e9uA:
undetectable		 4twdD-5e9uA:
20.66
4twdE-5e9uA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 6 TYR A  68
TYR A 203
LEU A 200
PHE A 189
 None
 1.29A 4twdF-5e9uA:
undetectable
4twdG-5e9uA:
undetectable		 4twdF-5e9uA:
20.66
4twdG-5e9uA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 10 HIS B 293
HIS B  76
LEU B 317
THR B 318
ALA B 316
 None
 1.45A 4yhaF-5e9uB:
undetectable		 4yhaF-5e9uB:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		3 / 3 GLY B 360
GLY B 361
GLN B  77
 None
 0.44A 5imsA-5e9uB:
3.0		 5imsA-5e9uB:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 10 ILE B  31
VAL B  30
TYR B   8
SER B  43
TYR B  45
 None
 1.44A 5u98A-5e9uB:
undetectable		 5u98A-5e9uB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		5 / 10 ILE B  31
VAL B  30
TYR B   8
SER B  43
TYR B  45
 None
 1.45A 5u98D-5e9uB:
undetectable		 5u98D-5e9uB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 TYR A 484
GLY A 428
LEU A 410
GLN A 430
LEU A 420
 None
 1.27A 5ubbA-5e9uA:
2.6		 5ubbA-5e9uA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 12 MET A 411
ALA A 481
SER A 477
LEU A 420
ILE A 433
 None
 1.34A 5vlmA-5e9uA:
undetectable		 5vlmA-5e9uA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		4 / 7 GLN B 123
GLY B  54
GLN B  13
TYR B   8
 None
 1.07A 5vlmE-5e9uB:
undetectable		 5vlmE-5e9uB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 10 GLY A  16
HIS A 242
LYS A 333
GLU A 404
GLY A 407
 UDP  A 601 (-3.1A)
NAG  A 602 (-3.6A)
UDP  A 601 ( 4.6A)
None
NAG  A 602 (-3.3A)
 1.14A 5vncC-5e9uA:
17.5		 5vncC-5e9uA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5e9u GLYCOSYLTRANSFERASE-
STABILIZING PROTEIN
GTF2
(Streptococcus
gordonii) 		3 / 3 ASN B 338
VAL B 363
HIS B 293
 None
 0.86A 6a5yD-5e9uB:
undetectable		 6a5yD-5e9uB:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 9 LEU A 311
ARG A 488
ALA A 481
VAL A 480
SER A 477
 None
 1.14A 6c2mB-5e9uA:
undetectable		 6c2mB-5e9uA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		5 / 9 VAL A 489
LEU A 311
ARG A 488
ALA A 481
SER A 477
 None
 1.09A 6c2mB-5e9uA:
undetectable		 6c2mB-5e9uA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		4 / 5 ARG A  24
ALA A  25
GLN A  21
ILE A  55
 None
 1.40A 6f6sA-5e9uA:
undetectable
6f6sB-5e9uA:
undetectable		 6f6sA-5e9uA:
8.95
6f6sB-5e9uA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 5e9u GLYCOSYLTRANSFERASE
GTF1
(Streptococcus
gordonii) 		3 / 3 TRP A 493
ILE A 276
GLU A 499
 None
 0.83A 6hcxA-5e9uA:
2.2		 6hcxA-5e9uA:
10.14