SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5e9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		10 / 12 LYS A 180
GLY A 205
GLY A 207
ILE A 228
ALA A 229
ASP A 261
SER A 262
GLN A 284
PHE A 285
TYR A 289
 SAH  A 500 (-2.6A)
SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 (-3.7A)
SAH  A 500 ( 3.9A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.1A)
None
None
SAH  A 500 (-4.0A)
 0.53A 1ri4A-5e9wA:
32.2		 1ri4A-5e9wA:
29.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ALA A 382
LEU A 378
PHE A 470
SER A 290
LEU A 204
 None
 1.34A 1u72A-5e9wA:
undetectable		 1u72A-5e9wA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 262
ASP A 203
CYH A 236
 SAH  A 500 (-4.1A)
SAH  A 500 ( 4.8A)
None
 1.17A 2br4E-5e9wA:
9.0		 2br4E-5e9wA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 6 LEU A 372
GLU A 323
ILE A 466
PRO A 319
 None
 1.07A 2fcnA-5e9wA:
undetectable
2fcnB-5e9wA:
undetectable		 2fcnA-5e9wA:
12.37
2fcnB-5e9wA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ASP A 203
GLY A 205
GLY A 207
GLY A 210
VAL A 286
 SAH  A 500 ( 4.8A)
SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 ( 4.4A)
SAH  A 500 (-3.8A)
 0.55A 2oxtD-5e9wA:
6.6		 2oxtD-5e9wA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ILE A 228
ASP A 261
TYR A 289
 SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 (-3.7A)
SAH  A 500 (-3.6A)
SAH  A 500 (-4.0A)
 0.64A 2qe6B-5e9wA:
15.4		 2qe6B-5e9wA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ASP A 203
LEU A 204
GLY A 205
ASP A 227
SER A 262
 SAH  A 500 ( 4.8A)
None
SAH  A 500 (-3.8A)
SAH  A 500 (-2.8A)
SAH  A 500 (-4.1A)
 0.96A 3cjtC-5e9wA:
13.2		 3cjtC-5e9wA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 CYH A 281
PHE A 472
PHE A 470
TYR A 385
 None
 1.16A 3hggA-5e9wA:
undetectable		 3hggA-5e9wA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ASP A 261
VAL A 286
TYR A 289
 SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 (-3.6A)
SAH  A 500 (-3.8A)
SAH  A 500 (-4.0A)
 0.56A 3o7wA-5e9wA:
13.9		 3o7wA-5e9wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A 207
ASP A 227
ASP A 261
 SAH  A 500 (-3.5A)
SAH  A 500 (-2.8A)
SAH  A 500 (-3.6A)
 0.25A 3ou7C-5e9wA:
14.4		 3ou7C-5e9wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 5 ILE A 466
ILE A 340
TYR A 341
GLU A 363
 None
 1.17A 4a99D-5e9wA:
undetectable		 4a99D-5e9wA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 PHE A 175
GLY A 454
ILE A 403
LEU A 412
 None
 0.65A 4ejjD-5e9wA:
undetectable		 4ejjD-5e9wA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ASP A 227
ILE A 228
ASP A 261
 SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 (-2.8A)
SAH  A 500 (-3.7A)
SAH  A 500 (-3.6A)
 0.36A 4iv8A-5e9wA:
16.0		 4iv8A-5e9wA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 205
GLY A 207
ASP A 227
ILE A 228
ASP A 261
 SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 (-2.8A)
SAH  A 500 (-3.7A)
SAH  A 500 (-3.6A)
 0.35A 4iv8B-5e9wA:
16.0		 4iv8B-5e9wA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		3 / 3 GLY A 311
GLN A 476
LYS A 194
 None
 0.87A 5imsB-5e9wA:
3.2		 5imsB-5e9wA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		6 / 12 GLY A 205
GLY A 207
ASP A 211
ILE A 228
SER A 262
VAL A 286
 SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 ( 4.0A)
SAH  A 500 (-3.7A)
SAH  A 500 (-4.1A)
SAH  A 500 (-3.8A)
 0.57A 6ectA-5e9wA:
14.5		 6ectA-5e9wA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		4 / 7 GLY A 185
PHE A 187
VAL A 191
SER A 282
 None
 0.93A 6hu9S-5e9wA:
undetectable
6hu9q-5e9wA:
undetectable		 6hu9S-5e9wA:
17.13
6hu9q-5e9wA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE
(Homo
sapiens) 		5 / 12 ASP A 203
GLY A 205
GLY A 207
ALA A 229
ASP A 261
 SAH  A 500 ( 4.8A)
SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 ( 3.9A)
SAH  A 500 (-3.6A)
 0.88A 6nj9K-5e9wA:
9.9		 6nj9K-5e9wA:
20.38