SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eaw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 5 LEU A 321
LEU A 273
SER A 134
LEU A 362
GLY A 128
None
1.36A 1a4lC-5eawA:
undetectable
1a4lC-5eawA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 GLU A 264
ILE A 266
ARG A 526
None
0.74A 1cd2A-5eawA:
undetectable
1cd2A-5eawA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 7 GLU A 452
LEU A 451
VAL A 370
LEU A  34
None
0.86A 1hk3A-5eawA:
undetectable
1hk3A-5eawA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 9 SER A 150
GLY A 149
ARG A 148
LEU A 576
GLY A 577
None
1.15A 1jb0A-5eawA:
2.2
1jb0A-5eawA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 7 PHE A 599
ILE A 596
TYR A 441
GLU A 808
None
0.90A 1oniD-5eawA:
undetectable
1oniF-5eawA:
undetectable
1oniD-5eawA:
9.06
1oniF-5eawA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 8 LEU A 810
GLU A 808
TYR A 441
ILE A 596
None
0.74A 1qvtA-5eawA:
undetectable
1qvtA-5eawA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 5 PHE A 167
LEU A 298
PHE A 175
MET A 226
None
1.32A 1wrkB-5eawA:
undetectable
1wrkB-5eawA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 8 LYS A 357
SER A  88
ARG A  84
GLU A 354
None
1.43A 1xr2B-5eawA:
undetectable
1xr2B-5eawA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 4 LEU A 317
SER A 134
LEU A 356
LEU A 273
None
1.14A 1yajA-5eawA:
undetectable
1yajA-5eawA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 6 LEU A 576
LEU A 579
LEU A 405
LEU A 143
None
1.02A 2ab2A-5eawA:
undetectable
2ab2A-5eawA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 6 MET A 197
ILE A 162
PRO A 750
SER A 753
None
1.32A 2qd3B-5eawA:
undetectable
2qd3B-5eawA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 6 LEU A 451
ASN A 798
LYS A 456
ASP A 457
None
1.23A 2w98A-5eawA:
2.7
2w98B-5eawA:
3.7
2w98A-5eawA:
16.40
2w98B-5eawA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 6 ASP A 684
ILE A 686
LEU A 675
GLU A 764
None
0.87A 2ya7A-5eawA:
undetectable
2ya7A-5eawA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 6 ASP A 684
ILE A 686
LEU A 675
GLU A 764
None
0.95A 2ya7B-5eawA:
undetectable
2ya7B-5eawA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 6 ASP A 684
ILE A 686
LEU A 675
GLU A 764
None
0.90A 2ya7D-5eawA:
undetectable
2ya7D-5eawA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 ILE A 921
THR A 898
VAL A 940
ILE A 941
GLN A 947
None
1.20A 2yzqA-5eawA:
2.4
2yzqA-5eawA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 9 VAL A 673
ILE A 761
ALA A 661
THR A 658
VAL A 784
None
1.24A 3me6C-5eawA:
undetectable
3me6C-5eawA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 11 LEU A 837
LEU A 841
LEU A1035
ASN A1036
LEU A1028
None
1.15A 3ndvA-5eawA:
undetectable
3ndvB-5eawA:
undetectable
3ndvA-5eawA:
17.08
3ndvB-5eawA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 9 SER A 150
GLY A 149
ARG A 148
LEU A 576
GLY A 577
None
1.15A 3pcqA-5eawA:
2.2
3pcqA-5eawA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 6 ILE A 647
VAL A 762
CYH A 744
ILE A 761
CYH A 760
None
1.34A 4asdA-5eawA:
2.9
4asdA-5eawA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 TYR A 944
PHE A1025
ARG A 985
None
0.87A 4g19D-5eawA:
undetectable
4g19D-5eawA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 7 LEU A 355
ARG A 312
PRO A 297
SER A 322
None
1.07A 4klrA-5eawA:
2.1
4klrA-5eawA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 5 LEU A 355
ARG A 312
PRO A 297
SER A 322
None
1.14A 4kmmB-5eawA:
undetectable
4kmmB-5eawA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 ARG A 591
LEU A 595
GLU A 594
None
0.65A 4l3gF-5eawA:
2.1
4l3gF-5eawA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 11 SER A 150
GLY A 149
ARG A 148
LEU A 576
GLY A 577
None
1.07A 4l6v1-5eawA:
2.2
4l6v6-5eawA:
undetectable
4l6v1-5eawA:
21.81
4l6v6-5eawA:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 8 ASN A1003
ARG A1000
ASP A 969
ILE A 941
None
1.02A 4l7iA-5eawA:
undetectable
4l7iA-5eawA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 ARG A 270
HIS A  99
SER A 268
None
0.87A 4mjwA-5eawA:
undetectable
4mjwB-5eawA:
undetectable
4mjwA-5eawA:
19.96
4mjwB-5eawA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 SER A 268
ARG A 270
HIS A  99
None
0.87A 4mjwA-5eawA:
undetectable
4mjwB-5eawA:
undetectable
4mjwA-5eawA:
19.96
4mjwB-5eawA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJJ_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 THR A  55
GLU A  64
GLU A  54
VAL A  69
ASP A  96
None
1.26A 4njjA-5eawA:
undetectable
4njjA-5eawA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 11 VAL A 786
ILE A 659
ILE A 665
THR A 645
ILE A 647
None
0.96A 4njtA-5eawA:
undetectable
4njtA-5eawA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 5 ILE A 665
ARG A 782
ASP A 758
VAL A 695
None
1.27A 4nkxD-5eawA:
undetectable
4nkxD-5eawA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 PRO A 122
MET A 124
TYR A 121
None
1.03A 4qa2B-5eawA:
4.9
4qa2B-5eawA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 5 GLN A 791
SER A 766
ASP A 763
ASP A 684
None
1.48A 4qtuB-5eawA:
3.2
4qtuB-5eawA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 8 ARG A 359
ALA A 363
LEU A 362
PHE A 442
None
1.05A 4rkuA-5eawA:
undetectable
4rkuJ-5eawA:
undetectable
4rkuA-5eawA:
22.05
4rkuJ-5eawA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 11 VAL A 786
ILE A 659
ILE A 665
THR A 645
ILE A 647
None
0.93A 4rvjA-5eawA:
undetectable
4rvjA-5eawA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 11 VAL A 786
ILE A 659
ILE A 665
THR A 645
ILE A 647
None
0.92A 4rvjC-5eawA:
undetectable
4rvjC-5eawA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 THR A 187
LEU A 185
ALA A 184
LEU A 180
MET A 197
None
1.04A 4xi3C-5eawA:
undetectable
4xi3C-5eawA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 CYH A 773
ILE A 747
PHE A 783
LEU A 592
LEU A 582
None
1.19A 4xumA-5eawA:
undetectable
4xumA-5eawA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 PHE A 983
ILE A 834
PHE A 895
LEU A1031
LEU A1002
None
1.19A 4xumA-5eawA:
undetectable
4xumA-5eawA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
6 / 12 VAL A 663
LEU A 662
ASP A 763
ILE A 761
VAL A 822
LEU A 824
None
1.31A 4y8wA-5eawA:
undetectable
4y8wA-5eawA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
6 / 12 VAL A 663
LEU A 662
ASP A 763
ILE A 761
VAL A 822
LEU A 824
None
1.28A 4y8wB-5eawA:
undetectable
4y8wB-5eawA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 ASN A 856
ALA A 855
ARG A 832
None
0.61A 5cvtB-5eawA:
undetectable
5cvtB-5eawA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 ASP A 564
ARG A 325
ARG A 526
None
0.75A 5eajB-5eawA:
undetectable
5eajB-5eawA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 VAL A 940
LEU A 896
LEU A 980
GLY A 939
LEU A1052
None
1.12A 5ienA-5eawA:
0.9
5ienA-5eawA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 LEU A 978
ILE A 951
VAL A 940
GLY A 939
ILE A 938
None
0.76A 5j2tC-5eawA:
undetectable
5j2tC-5eawA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 ARG A 829
PRO A 651
ASN A1003
ADP  A1102 ( 4.6A)
None
None
0.93A 5jwaA-5eawA:
undetectable
5jwaH-5eawA:
undetectable
5jwaA-5eawA:
18.83
5jwaH-5eawA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 THR A1007
PRO A 651
ASP A 788
None
0.85A 5l8dB-5eawA:
0.3
5l8dB-5eawA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8R_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 9 SER A 150
GLY A 149
ARG A 148
LEU A 576
GLY A 577
None
1.15A 5l8rA-5eawA:
undetectable
5l8rA-5eawA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
3 / 3 THR A1007
PRO A 651
ASP A 788
None
0.85A 5mwuB-5eawA:
0.3
5mwuB-5eawA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 VAL A 968
LEU A1028
LEU A1002
ALA A1005
ARG A 985
None
1.07A 5nd7B-5eawA:
undetectable
5nd7B-5eawA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 11 LEU A 317
GLY A 275
LEU A 355
THR A 129
ALA A 132
None
1.14A 5o96A-5eawA:
undetectable
5o96B-5eawA:
undetectable
5o96A-5eawA:
14.10
5o96B-5eawA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 12 ILE A1055
VAL A 915
LEU A1052
THR A 898
LEU A1044
None
1.18A 6b54A-5eawA:
undetectable
6b54A-5eawA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 9 VAL A 638
VAL A 673
LEU A 639
GLY A 670
CYH A 669
None
1.30A 6czmD-5eawA:
undetectable
6czmE-5eawA:
undetectable
6czmD-5eawA:
17.70
6czmE-5eawA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 10 VAL A 638
VAL A 673
LEU A 639
GLY A 670
CYH A 669
None
1.29A 6czmE-5eawA:
undetectable
6czmF-5eawA:
undetectable
6czmE-5eawA:
17.70
6czmF-5eawA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
5 / 9 LEU A 883
VAL A 886
SER A 982
LEU A 980
ILE A1014
None
1.39A 6fdyU-5eawA:
undetectable
6fdyU-5eawA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus
musculus)
4 / 8 GLN A 399
ALA A 132
VAL A 131
ASP A 151
None
0.94A 6hu9a-5eawA:
undetectable
6hu9e-5eawA:
undetectable
6hu9a-5eawA:
19.91
6hu9e-5eawA:
8.63