SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eb2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eb2 YFIR
(Pseudomonas
aeruginosa) 		4 / 8 SER A 168
ARG A 171
PHE A 127
ASN A 165
 None
 1.31A 1rs7B-5eb2A:
undetectable		 1rs7B-5eb2A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eb2 YFIR
(Pseudomonas
aeruginosa) 		4 / 8 SER A 168
ARG A 171
PHE A 127
ASN A 165
 None
 1.29A 1zzqB-5eb2A:
undetectable		 1zzqB-5eb2A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5eb2 YFIR
(Pseudomonas
aeruginosa) 		4 / 8 SER A 168
ARG A 171
PHE A 127
ASN A 165
 None
 1.14A 1zzuA-5eb2A:
undetectable		 1zzuA-5eb2A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5eb2 YFIR
(Pseudomonas
aeruginosa) 		4 / 6 PHE A 127
ILE A 113
GLY A 116
GLY A  74
 None
 0.82A 2qx6A-5eb2A:
3.2
2qx6B-5eb2A:
undetectable		 2qx6A-5eb2A:
23.31
2qx6B-5eb2A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5eb2 YFIR
(Pseudomonas
aeruginosa) 		4 / 8 SER A 168
ARG A 171
PHE A 127
ASN A 165
 None
 1.19A 3n62B-5eb2A:
undetectable		 3n62B-5eb2A:
17.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EB3_A_UEGA202_1
(YFIR)		 5eb2 YFIR
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 166
ILE A 169
PRO A 178
LEU A 181
 None
TRP  A 201 ( 4.3A)
TRP  A 201 (-4.0A)
None
 0.18A 5eb3A-5eb2A:
32.1		 5eb3A-5eb2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5eb2 YFIR
(Pseudomonas
aeruginosa) 		4 / 5 GLY A  91
ASN A  90
ARG A  93
ARG A  92
 None
 1.24A 6dwdB-5eb2A:
undetectable
6dwdD-5eb2A:
undetectable		 6dwdB-5eb2A:
14.05
6dwdD-5eb2A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5eb2 YFIR
(Pseudomonas
aeruginosa) 		4 / 5 ARG A  93
ARG A  92
GLY A  91
ASN A  90
 None
 1.11A 6dwjB-5eb2A:
undetectable
6dwjD-5eb2A:
undetectable		 6dwjB-5eb2A:
14.05
6dwjD-5eb2A:
14.05