SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 LEU A 201
ILE A 255
ARG A 484
VAL A  51
 None
 0.85A 1db1A-5eb5A:
undetectable		 1db1A-5eb5A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 VAL A 485
VAL A 272
LEU A 267
GLY A 479
LEU A 483
 None
 0.98A 1eqhA-5eb5A:
undetectable		 1eqhA-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NCW_H_BEZH601_0
(IMMUNOGLOBULIN IGG2A)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 9 ALA A 165
LEU A 410
GLY A 408
GLY A 403
TYR A 326
 None
 0.94A 1ncwH-5eb5A:
undetectable
1ncwL-5eb5A:
1.2		 1ncwH-5eb5A:
18.71
1ncwL-5eb5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 9 ALA A 165
LEU A 410
GLY A 408
GLY A 403
TYR A 326
 None
 0.95A 1ru9H-5eb5A:
1.1
1ru9L-5eb5A:
undetectable		 1ru9H-5eb5A:
18.71
1ru9L-5eb5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 10 ALA A 165
LEU A 410
GLY A 408
GLY A 403
TYR A 326
 None
 0.93A 1ruaH-5eb5A:
undetectable
1ruaL-5eb5A:
undetectable		 1ruaH-5eb5A:
18.71
1ruaL-5eb5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 9 ALA A 165
LEU A 410
GLY A 408
GLY A 403
TYR A 326
 None
 0.97A 1rulH-5eb5A:
undetectable
1rulL-5eb5A:
undetectable		 1rulH-5eb5A:
18.71
1rulL-5eb5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUM_H_BEZH1601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 9 ALA A 165
LEU A 410
GLY A 408
GLY A 403
TYR A 326
 None
 0.95A 1rumH-5eb5A:
undetectable
1rumL-5eb5A:
1.2		 1rumH-5eb5A:
18.71
1rumL-5eb5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUP_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 9 ALA A 165
LEU A 410
GLY A 408
GLY A 403
TYR A 326
 None
 0.94A 1rupH-5eb5A:
undetectable
1rupL-5eb5A:
1.2		 1rupH-5eb5A:
18.71
1rupL-5eb5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 7 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.80A 1usqA-5eb5A:
undetectable		 1usqA-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.82A 1usqB-5eb5A:
undetectable		 1usqB-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.83A 1usqC-5eb5A:
undetectable		 1usqC-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.81A 1usqD-5eb5A:
undetectable		 1usqD-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.79A 1usqE-5eb5A:
undetectable		 1usqE-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 LEU A 320
ALA A 115
HIS A 460
TYR A 458
 None
None
FAD  A 601 (-4.0A)
010  A 609 (-4.5A)
 1.37A 2dpzA-5eb5A:
undetectable		 2dpzA-5eb5A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 LEU A 452
LEU A 397
PRO A 300
VAL A 363
 None
 1.17A 2dqyC-5eb5A:
undetectable		 2dqyC-5eb5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 8 TYR A  63
ASN A  75
ARG A  88
TYR A  74
 None
 1.01A 2fl5E-5eb5A:
undetectable
2fl5F-5eb5A:
undetectable		 2fl5E-5eb5A:
20.58
2fl5F-5eb5A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.86A 2jkjA-5eb5A:
undetectable		 2jkjA-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.86A 2jkjB-5eb5A:
undetectable		 2jkjB-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.86A 2jkjC-5eb5A:
undetectable		 2jkjC-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 7 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.83A 2jklA-5eb5A:
undetectable		 2jklA-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.84A 2jklB-5eb5A:
undetectable		 2jklB-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 7 PRO A 288
GLY A 273
ILE A 283
GLY A 271
 None
 0.83A 2jklF-5eb5A:
undetectable		 2jklF-5eb5A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 7 GLY A 464
GLY A 463
ASP A 487
LEU A 267
 None
None
FAD  A 601 (-4.6A)
None
 0.77A 2oa1B-5eb5A:
8.4		 2oa1B-5eb5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 THR A 181
ILE A 167
GLY A 321
GLY A 159
ILE A 158
 None
 1.32A 2y7kC-5eb5A:
undetectable		 2y7kC-5eb5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 9 THR A 181
ILE A 167
GLY A 321
GLY A 159
ILE A 158
 None
 1.28A 2y7wA-5eb5A:
undetectable		 2y7wA-5eb5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 10 THR A 181
ILE A 167
GLY A 321
GLY A 159
ILE A 158
 None
 1.26A 2y7wB-5eb5A:
undetectable		 2y7wB-5eb5A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 THR A  36
GLY A 104
ILE A  59
LEU A 200
VAL A 211
 FAD  A 601 (-3.0A)
None
None
None
None
 1.27A 3fzgA-5eb5A:
undetectable		 3fzgA-5eb5A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 CYH A  39
GLY A  38
GLY A  34
GLY A 104
ARG A  56
 None
None
None
None
FAD  A 601 (-4.3A)
 0.90A 3huoB-5eb5A:
undetectable		 3huoB-5eb5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 8 SER A  91
ASP A 298
TYR A 390
LEU A 343
 None
 0.94A 3jq7B-5eb5A:
3.5		 3jq7B-5eb5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 7 TYR A 509
GLU A 517
LEU A 506
TRP A 129
 None
 1.40A 3k8mB-5eb5A:
undetectable		 3k8mB-5eb5A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 VAL A 485
VAL A 272
LEU A 267
GLY A 479
LEU A 483
 None
 0.93A 3rr3A-5eb5A:
undetectable		 3rr3A-5eb5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 VAL A 485
VAL A 272
LEU A 267
GLY A 479
LEU A 483
 None
 0.91A 3rr3B-5eb5A:
undetectable		 3rr3B-5eb5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		3 / 3 PHE A 356
GLN A 155
PHE A 336
 None
 0.80A 3rv5A-5eb5A:
undetectable		 3rv5A-5eb5A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 11 LEU A 229
ILE A 220
VAL A 272
LEU A 267
VAL A 470
 None
 1.10A 3w67A-5eb5A:
1.0		 3w67A-5eb5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 6 ILE A 127
PHE A 121
TYR A 509
VAL A 141
 None
 1.19A 4a97I-5eb5A:
undetectable		 4a97I-5eb5A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.98A 4e3aA-5eb5A:
2.3		 4e3aA-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 11 LEU A 266
VAL A 256
ALA A 231
PHE A 222
SER A 270
 FAD  A 601 ( 4.7A)
None
None
None
None
 1.31A 4evrA-5eb5A:
2.7		 4evrA-5eb5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 LEU A 209
VAL A  51
ALA A  43
GLU A  47
LEU A 515
 None
 1.14A 4i1rA-5eb5A:
undetectable		 4i1rA-5eb5A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		3 / 3 HIS A   7
GLY A 104
ILE A 108
 None
 0.56A 4k50A-5eb5A:
undetectable		 4k50A-5eb5A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		3 / 3 HIS A   7
GLY A 104
ILE A 108
 None
 0.56A 4k50I-5eb5A:
undetectable		 4k50I-5eb5A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.98A 4k8pA-5eb5A:
2.4		 4k8pA-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 1.00A 4k8pB-5eb5A:
2.4		 4k8pB-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 1.00A 4k8tA-5eb5A:
2.3		 4k8tA-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.98A 4k8tB-5eb5A:
2.8		 4k8tB-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.99A 4k93A-5eb5A:
2.4		 4k93A-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.99A 4k93B-5eb5A:
2.4		 4k93B-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.99A 4k9cA-5eb5A:
2.3		 4k9cA-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.99A 4k9cB-5eb5A:
2.6		 4k9cB-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.97A 4k9iA-5eb5A:
2.4		 4k9iA-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.97A 4k9iB-5eb5A:
2.4		 4k9iB-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.99A 4kadA-5eb5A:
2.4		 4kadA-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.98A 4kadB-5eb5A:
2.4		 4kadB-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOS_A_4KOA201_1
(UNCHARACTERIZED
PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 PRO A 352
TYR A 349
GLY A 434
ILE A 304
PHE A 356
 None
 1.24A 4kosA-5eb5A:
undetectable		 4kosA-5eb5A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 11 GLY A 192
ALA A  69
ILE A 145
THR A 318
VAL A 316
 None
 1.03A 4l1aA-5eb5A:
undetectable		 4l1aA-5eb5A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.99A 4lbxA-5eb5A:
2.3		 4lbxA-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.98A 4lbxB-5eb5A:
2.3		 4lbxB-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.98A 4lc4A-5eb5A:
2.3		 4lc4A-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 108
GLY A 105
GLY A 104
THR A  66
LEU A  67
 None
FAD  A 601 (-3.4A)
None
None
None
 0.99A 4lc4B-5eb5A:
2.3		 4lc4B-5eb5A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 GLY A 252
VAL A 510
ARG A 249
VAL A 234
ILE A  32
 None
 1.01A 4q5mA-5eb5A:
undetectable		 4q5mA-5eb5A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 7 LEU A 267
SER A 270
ILE A 220
VAL A 234
 None
 0.94A 4tvtA-5eb5A:
undetectable		 4tvtA-5eb5A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ASN A  97
ASP A  93
ILE A 386
GLN A 265
ILE A 261
 None
 1.24A 4uroB-5eb5A:
undetectable		 4uroB-5eb5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 5 VAL A 256
TYR A 138
PRO A  40
THR A 187
 None
 1.32A 4ze1A-5eb5A:
undetectable		 4ze1A-5eb5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 5 SER A 270
ARG A  56
GLY A  33
GLU A  55
 None
FAD  A 601 (-4.3A)
FAD  A 601 (-3.3A)
FAD  A 601 (-2.9A)
 1.19A 5btiA-5eb5A:
undetectable
5btiB-5eb5A:
undetectable		 5btiA-5eb5A:
22.83
5btiB-5eb5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 5 SER A 270
ARG A  56
GLY A  33
GLU A  55
 None
FAD  A 601 (-4.3A)
FAD  A 601 (-3.3A)
FAD  A 601 (-2.9A)
 1.19A 5btiC-5eb5A:
undetectable
5btiD-5eb5A:
undetectable		 5btiC-5eb5A:
22.83
5btiD-5eb5A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 11 SER A  37
THR A  36
ALA A 258
GLY A 259
THR A 260
 FAD  A 601 (-4.4A)
FAD  A 601 (-3.0A)
FAD  A 601 (-3.5A)
FAD  A 601 ( 3.8A)
None
 1.27A 5bxnV-5eb5A:
undetectable
5bxnW-5eb5A:
undetectable		 5bxnV-5eb5A:
18.15
5bxnW-5eb5A:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		11 / 11 ALA A 111
ARG A 301
ALA A 317
VAL A 329
LEU A 331
LEU A 343
HIS A 358
VAL A 360
TYR A 458
TRP A 459
HIS A 498
 FAD  A 601 ( 3.2A)
None
010  A 609 ( 3.9A)
None
010  A 609 ( 3.9A)
None
010  A 609 (-4.6A)
010  A 609 ( 4.8A)
010  A 609 (-4.5A)
FAD  A 601 ( 3.7A)
010  A 609 ( 4.0A)
 0.00A 5eb5A-5eb5A:
71.4		 5eb5A-5eb5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		6 / 11 ALA A 111
ARG A 301
LEU A 343
HIS A 358
VAL A 360
HIS A 460
 FAD  A 601 ( 3.2A)
None
None
010  A 609 (-4.6A)
010  A 609 ( 4.8A)
FAD  A 601 (-4.0A)
 1.41A 5eb5A-5eb5A:
71.4		 5eb5A-5eb5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		10 / 10 ALA A 111
ARG A 301
ALA A 317
VAL A 329
LEU A 343
HIS A 358
VAL A 360
TYR A 458
TRP A 459
HIS A 498
 FAD  A 601 ( 3.2A)
None
010  A 609 ( 3.9A)
None
None
010  A 609 (-4.6A)
010  A 609 ( 4.8A)
010  A 609 (-4.5A)
FAD  A 601 ( 3.7A)
010  A 609 ( 4.0A)
 0.16A 5eb5B-5eb5A:
68.5		 5eb5B-5eb5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		6 / 10 ALA A 111
ARG A 301
LEU A 343
HIS A 358
VAL A 360
HIS A 460
 FAD  A 601 ( 3.2A)
None
None
010  A 609 (-4.6A)
010  A 609 ( 4.8A)
FAD  A 601 (-4.0A)
 1.44A 5eb5B-5eb5A:
68.5		 5eb5B-5eb5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 312
PHE A 430
VAL A 435
THR A 413
LEU A 410
 None
 1.30A 5esgA-5eb5A:
undetectable		 5esgA-5eb5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ASP A 487
ALA A 488
THR A 187
GLY A 501
SER A  37
 FAD  A 601 (-4.6A)
FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-4.4A)
 1.23A 5hfjC-5eb5A:
undetectable		 5hfjC-5eb5A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ASP A 487
ALA A 488
THR A 187
GLY A 501
SER A  37
 FAD  A 601 (-4.6A)
FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-4.4A)
 1.27A 5hfjF-5eb5A:
undetectable		 5hfjF-5eb5A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ASP A 487
ALA A 488
THR A 187
GLY A 501
SER A  37
 FAD  A 601 (-4.6A)
FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-4.4A)
 1.32A 5hfjH-5eb5A:
undetectable		 5hfjH-5eb5A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 VAL A 256
ASP A 487
LEU A 374
THR A 373
GLY A 463
 None
FAD  A 601 (-4.6A)
None
None
None
 1.27A 5ogcB-5eb5A:
undetectable		 5ogcB-5eb5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ALA A  43
LEU A 515
ILE A 514
ARG A 484
VAL A  31
 None
 1.11A 5vlmE-5eb5A:
undetectable		 5vlmE-5eb5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ALA A  43
LEU A 515
ILE A 514
ARG A 484
VAL A  31
 None
 1.29A 5vlmG-5eb5A:
undetectable		 5vlmG-5eb5A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		4 / 4 ASP A 240
SER A 239
ASP A 238
HIS A 244
 None
 1.05A 5wyqB-5eb5A:
undetectable		 5wyqB-5eb5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 PHE A 475
LEU A 267
ILE A 480
LEU A 506
LEU A  41
 None
 1.49A 5ycpA-5eb5A:
undetectable		 5ycpA-5eb5A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 109
VAL A 510
LEU A  45
VAL A  31
LEU A 506
 None
 1.17A 6a7pB-5eb5A:
undetectable		 6a7pB-5eb5A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5eb5 HNL ISOENZYME 5
(Prunus
dulcis) 		5 / 12 ILE A 261
THR A 260
VAL A  31
VAL A 254
SER A  37
 None
None
None
None
FAD  A 601 (-4.4A)
 1.19A 6bzoC-5eb5A:
undetectable		 6bzoC-5eb5A:
19.08