SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ebb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 ALA A 318
VAL A  43
TRP A 107
 None
 0.90A 1av2A-5ebbA:
undetectable
1av2B-5ebbA:
undetectable		 1av2A-5ebbA:
3.98
1av2B-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 ALA A 318
VAL A  43
TRP A 107
 None
 0.76A 1c4dC-5ebbA:
undetectable
1c4dD-5ebbA:
undetectable		 1c4dC-5ebbA:
3.98
1c4dD-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 TRP A 107
ALA A 318
VAL A  43
 None
 0.84A 1c4dC-5ebbA:
undetectable
1c4dD-5ebbA:
undetectable		 1c4dC-5ebbA:
3.98
1c4dD-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 SER A 165
ARG A 188
ALA A 172
LEU A 187
GLY A 191
 None
 1.31A 1jb0A-5ebbA:
undetectable		 1jb0A-5ebbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 ASP A 110
HIS A 152
HIS A  47
 ZN  A 701 (-2.5A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.64A 1oe1A-5ebbA:
undetectable		 1oe1A-5ebbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 ASP A 110
HIS A 152
HIS A  47
 ZN  A 701 (-2.5A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.63A 1oe3A-5ebbA:
undetectable		 1oe3A-5ebbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 GLY A 191
GLY A 190
PRO A 161
ASP A 153
ASN A 169
 None
 1.07A 1qzzA-5ebbA:
undetectable		 1qzzA-5ebbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 ALA A 318
VAL A  43
TRP A 107
 None
 0.92A 1w5uA-5ebbA:
undetectable
1w5uB-5ebbA:
undetectable		 1w5uA-5ebbA:
3.98
1w5uB-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 TRP A 107
ALA A 318
VAL A  43
 None
 0.99A 1w5uA-5ebbA:
undetectable
1w5uB-5ebbA:
undetectable		 1w5uA-5ebbA:
3.98
1w5uB-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 LEU A  46
ILE A  95
LEU A 174
VAL A 171
VAL A 145
 None
 1.12A 2hrcB-5ebbA:
undetectable		 2hrcB-5ebbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 TRP A 107
ALA A 318
VAL A  43
 None
 0.89A 2izqC-5ebbA:
undetectable
2izqD-5ebbA:
undetectable		 2izqC-5ebbA:
3.98
2izqD-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 ASP A 341
TYR A 345
LYS A 246
 None
 1.15A 2othA-5ebbA:
undetectable		 2othA-5ebbA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 SER A 165
ARG A 188
ALA A 172
LEU A 187
GLY A 191
 None
 1.38A 2wscA-5ebbA:
undetectable		 2wscA-5ebbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 SER A 165
ARG A 188
ALA A 172
LEU A 187
GLY A 191
 None
 1.38A 2wseA-5ebbA:
undetectable		 2wseA-5ebbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 SER A 165
ARG A 188
ALA A 172
LEU A 187
GLY A 191
 None
 1.35A 2wsfA-5ebbA:
undetectable		 2wsfA-5ebbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 ASP A 110
HIS A 152
HIS A  47
 ZN  A 701 (-2.5A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.65A 2xxgA-5ebbA:
undetectable		 2xxgA-5ebbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 ASP A 110
HIS A 152
HIS A  47
 ZN  A 701 (-2.5A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.65A 2xxgC-5ebbA:
undetectable		 2xxgC-5ebbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 THR A  44
ILE A 250
GLY A 109
ASP A 158
VAL A 253
 None
 1.17A 2yvlD-5ebbA:
undetectable		 2yvlD-5ebbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.34A 2zweA-5ebbA:
undetectable
2zweB-5ebbA:
undetectable		 2zweA-5ebbA:
20.24
2zweB-5ebbA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.36A 2zwfA-5ebbA:
undetectable
2zwfB-5ebbA:
undetectable		 2zwfA-5ebbA:
20.24
2zwfB-5ebbA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.36A 2zwgA-5ebbA:
undetectable
2zwgB-5ebbA:
0.0		 2zwgA-5ebbA:
20.24
2zwgB-5ebbA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 5 ASP A 153
ILE A 136
ILE A 129
GLY A 109
 None
 0.91A 3bufA-5ebbA:
undetectable		 3bufA-5ebbA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 5 HIS A  47
HIS A 114
ASP A 110
HIS A 152
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
ZN  A 701 (-2.5A)
MLI  A 706 (-3.9A)
 1.26A 3c0zA-5ebbA:
undetectable		 3c0zA-5ebbA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 LEU A 139
GLN A 137
TYR A  85
PHE A  92
LEU A  46
 None
None
NAG  A 704 (-4.0A)
None
None
 1.29A 3gwuA-5ebbA:
undetectable		 3gwuA-5ebbA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 TRP A 107
ALA A 318
VAL A  43
 None
 0.94A 3l8lC-5ebbA:
undetectable
3l8lD-5ebbA:
undetectable		 3l8lC-5ebbA:
3.98
3l8lD-5ebbA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 SER A 165
ARG A 188
ALA A 172
LEU A 187
GLY A 191
 None
 1.34A 3lw5A-5ebbA:
undetectable		 3lw5A-5ebbA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 TYR A 406
LEU A 388
LEU A 374
ILE A 276
GLY A 256
 None
 1.14A 3ozwB-5ebbA:
undetectable		 3ozwB-5ebbA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 SER A 165
ARG A 188
ALA A 172
LEU A 187
GLY A 191
 None
 1.31A 3pcqA-5ebbA:
undetectable		 3pcqA-5ebbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 7 ASN A 211
ASP A  45
HIS A 295
HIS A  47
 None
ZN  A 702 ( 3.0A)
ZN  A 702 ( 3.4A)
ZN  A 702 ( 3.4A)
 1.03A 3t01A-5ebbA:
undetectable		 3t01A-5ebbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 5 LEU A  89
ALA A  91
MET A 132
THR A 135
 None
None
None
NAG  A 704 ( 4.6A)
 1.17A 3vasB-5ebbA:
undetectable		 3vasB-5ebbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 6 ASN A 151
GLY A 150
ASP A 153
ILE A 129
 MLI  A 706 ( 2.6A)
None
None
None
 1.04A 3w9tF-5ebbA:
undetectable		 3w9tF-5ebbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 TYR A 168
LEU A 160
LEU A 149
GLY A 150
VAL A 125
 None
 1.40A 4c9kA-5ebbA:
undetectable		 4c9kA-5ebbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 TYR A 168
LEU A 160
LEU A 149
GLY A 150
VAL A 125
 None
 1.39A 4c9kB-5ebbA:
undetectable		 4c9kB-5ebbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 10 SER A 165
ARG A 188
ALA A 172
LEU A 187
GLY A 191
 None
 1.35A 4fe1A-5ebbA:
undetectable
4fe1J-5ebbA:
undetectable		 4fe1A-5ebbA:
19.12
4fe1J-5ebbA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 TYR A 282
THR A 236
VAL A 247
ILE A 278
 None
 1.07A 4jx1F-5ebbA:
undetectable		 4jx1F-5ebbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 LEU A 435
VAL A 255
VAL A 301
PHE A 279
VAL A 315
 None
 1.21A 4nc3A-5ebbA:
undetectable		 4nc3A-5ebbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 8 TYR A 406
ILE A 299
ILE A 432
ALA A 431
 None
 0.96A 4ou1A-5ebbA:
undetectable		 4ou1A-5ebbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 8 SER A 165
ARG A 188
ALA A 172
LEU A 187
 None
 0.91A 4rkuA-5ebbA:
undetectable
4rkuJ-5ebbA:
undetectable		 4rkuA-5ebbA:
19.75
4rkuJ-5ebbA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 7 SER A 165
ARG A 188
ALA A 172
LEU A 187
 None
 0.91A 4xk8A-5ebbA:
undetectable		 4xk8A-5ebbA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 9 SER A 165
ARG A 188
ALA A 172
LEU A 187
GLY A 191
 None
 1.30A 4y28A-5ebbA:
undetectable
4y28J-5ebbA:
undetectable		 4y28A-5ebbA:
19.71
4y28J-5ebbA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 8 LEU A 208
THR A 236
LEU A 237
LEU A 233
 None
 0.65A 4z90F-5ebbA:
undetectable
4z90G-5ebbA:
undetectable
4z90H-5ebbA:
undetectable
4z90I-5ebbA:
undetectable
4z90J-5ebbA:
undetectable		 4z90F-5ebbA:
20.23
4z90G-5ebbA:
20.23
4z90H-5ebbA:
20.23
4z90I-5ebbA:
20.23
4z90J-5ebbA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 7 ILE A 286
PHE A 279
VAL A 247
ILE A 206
 None
 0.70A 4zzbC-5ebbA:
undetectable
4zzbD-5ebbA:
undetectable		 4zzbC-5ebbA:
23.40
4zzbD-5ebbA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 PRO A 216
HIS A  47
HIS A 114
ASP A 110
TYR A 214
 None
ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
ZN  A 701 (-2.5A)
None
 1.47A 5eenB-5ebbA:
undetectable		 5eenB-5ebbA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 5 GLY A 292
PRO A 333
THR A  44
THR A 294
 None
 1.13A 5h5fA-5ebbA:
undetectable		 5h5fA-5ebbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 GLY A 292
ALA A 266
LEU A 258
GLY A 150
ASP A 110
 None
None
None
None
ZN  A 701 (-2.5A)
 0.83A 5kb5A-5ebbA:
undetectable		 5kb5A-5ebbA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 TRP A 175
ILE A 136
THR A 135
PHE A  92
VAL A  43
 None
None
NAG  A 704 ( 4.6A)
None
None
 1.14A 5l8oB-5ebbA:
undetectable		 5l8oB-5ebbA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.81A 5mhwA-5ebbA:
undetectable		 5mhwA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.81A 5mhxA-5ebbA:
undetectable		 5mhxA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.81A 5mhyA-5ebbA:
undetectable		 5mhyA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.82A 5mhzA-5ebbA:
undetectable		 5mhzA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.82A 5mi1A-5ebbA:
undetectable		 5mi1A-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.82A 5mi2A-5ebbA:
undetectable		 5mi2A-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.83A 5miaA-5ebbA:
undetectable		 5miaA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.83A 5mibA-5ebbA:
undetectable		 5mibA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.82A 5micA-5ebbA:
undetectable		 5micA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.82A 5midA-5ebbA:
undetectable		 5midA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 HIS A 295
HIS A 152
HIS A 114
HIS A  47
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.83A 5mieA-5ebbA:
undetectable		 5mieA-5ebbA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		4 / 4 SER A  64
THR A 330
ASP A 415
ASP A  78
 None
 1.22A 5vimB-5ebbA:
undetectable		 5vimB-5ebbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 12 LEU A 149
PRO A 147
ALA A 148
GLU A 182
THR A 186
 None
 1.09A 5x6yA-5ebbA:
undetectable		 5x6yA-5ebbA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.34A 5z0fA-5ebbA:
undetectable
5z0fB-5ebbA:
undetectable		 5z0fA-5ebbA:
15.73
5z0fB-5ebbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.37A 5z0gA-5ebbA:
undetectable
5z0gB-5ebbA:
undetectable		 5z0gA-5ebbA:
15.73
5z0gB-5ebbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.39A 5z0hA-5ebbA:
undetectable
5z0hB-5ebbA:
undetectable		 5z0hA-5ebbA:
15.73
5z0hB-5ebbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.37A 5z0iA-5ebbA:
undetectable
5z0iB-5ebbA:
0.0		 5z0iA-5ebbA:
15.73
5z0iB-5ebbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.36A 5z0jA-5ebbA:
undetectable
5z0jB-5ebbA:
undetectable		 5z0jA-5ebbA:
15.73
5z0jB-5ebbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.37A 5z0kA-5ebbA:
undetectable
5z0kB-5ebbA:
undetectable		 5z0kA-5ebbA:
15.73
5z0kB-5ebbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.39A 5z0lA-5ebbA:
undetectable
5z0lB-5ebbA:
undetectable		 5z0lA-5ebbA:
15.73
5z0lB-5ebbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		5 / 11 HIS A 295
HIS A 152
HIS A 114
VAL A 115
PRO A  50
 ZN  A 702 ( 3.4A)
MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
None
NAG  A 704 ( 4.7A)
 1.40A 5z0mA-5ebbA:
undetectable
5z0mB-5ebbA:
undetectable		 5z0mA-5ebbA:
15.73
5z0mB-5ebbA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens) 		3 / 3 HIS A 152
HIS A 114
HIS A  47
 MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.75A 6giqa-5ebbA:
undetectable		 6giqa-5ebbA:
19.71