SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ec0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 5 LYS A 158
LEU A 160
GLU A 167
LEU A  57
 None
 1.02A 1eta1-5ec0A:
undetectable		 1eta1-5ec0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 5 LYS A 158
LEU A 160
GLU A 167
LEU A  57
 None
 0.97A 1eta2-5ec0A:
undetectable		 1eta2-5ec0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 6 LYS A 158
LEU A 160
GLU A 167
LEU A  57
 None
 1.03A 1etb1-5ec0A:
undetectable		 1etb1-5ec0A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 7 ILE A  33
PHE A  69
ALA A  75
ILE A  96
 None
 0.96A 1oniB-5ec0A:
undetectable
1oniC-5ec0A:
undetectable		 1oniB-5ec0A:
17.46
1oniC-5ec0A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 6 LYS A 158
LEU A 160
GLU A 167
LEU A  57
 None
 0.74A 1sn5A-5ec0A:
undetectable		 1sn5A-5ec0A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 8 LYS A 158
LEU A 160
GLU A 167
LEU A  57
 None
 0.79A 1sn5C-5ec0A:
undetectable		 1sn5C-5ec0A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 4 LEU A 300
SER A 299
TYR A 303
LEU A 335
 None
 1.29A 1xz3A-5ec0A:
undetectable		 1xz3A-5ec0A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 6 PHE A 151
THR A 127
LEU A 129
ALA A 148
 None
 1.01A 2e1qA-5ec0A:
undetectable		 2e1qA-5ec0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 5 PHE A 151
THR A 127
LEU A 129
ALA A 148
 None
 1.03A 2e1qD-5ec0A:
undetectable		 2e1qD-5ec0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		5 / 12 VAL A 331
CYH A 211
GLN A 310
ALA A 311
THR A 314
 ADP  A 403 ( 4.8A)
None
None
None
None
 1.15A 3a35B-5ec0A:
undetectable		 3a35B-5ec0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		5 / 12 VAL A 331
CYH A 211
ILE A 308
GLN A 310
ALA A 311
 ADP  A 403 ( 4.8A)
None
None
None
None
 1.02A 3ddyA-5ec0A:
undetectable		 3ddyA-5ec0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		3 / 3 GLU A 173
GLY A 153
THR A 154
 None
 0.54A 3iazA-5ec0A:
undetectable		 3iazA-5ec0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5ec0 ALP7A
(Bacillus
subtilis) 		5 / 12 TYR A 327
GLU A 360
ALA A 359
GLY A 329
LEU A 365
 None
None
None
ADP  A 403 (-3.6A)
None
 1.26A 3ou6D-5ec0A:
undetectable		 3ou6D-5ec0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 5 GLU A 333
GLY A 330
TYR A 271
GLU A 267
 ADP  A 403 (-4.2A)
ADP  A 403 (-3.0A)
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 1.14A 3w9tA-5ec0A:
undetectable		 3w9tA-5ec0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 6 GLU A 333
GLY A 330
TYR A 271
GLU A 267
 ADP  A 403 (-4.2A)
ADP  A 403 (-3.0A)
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 1.14A 3w9tB-5ec0A:
undetectable		 3w9tB-5ec0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 5 GLU A 333
GLY A 330
TYR A 271
GLU A 267
 ADP  A 403 (-4.2A)
ADP  A 403 (-3.0A)
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 1.15A 3w9tC-5ec0A:
undetectable		 3w9tC-5ec0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 5 GLU A 333
GLY A 330
TYR A 271
GLU A 267
 ADP  A 403 (-4.2A)
ADP  A 403 (-3.0A)
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 1.14A 3w9tD-5ec0A:
undetectable		 3w9tD-5ec0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 6 GLU A 333
GLY A 330
TYR A 271
GLU A 267
 ADP  A 403 (-4.2A)
ADP  A 403 (-3.0A)
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 1.14A 3w9tE-5ec0A:
undetectable		 3w9tE-5ec0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 6 GLU A 333
GLY A 330
TYR A 271
GLU A 267
 ADP  A 403 (-4.2A)
ADP  A 403 (-3.0A)
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 1.15A 3w9tF-5ec0A:
undetectable		 3w9tF-5ec0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 5 GLU A 333
GLY A 330
TYR A 271
GLU A 267
 ADP  A 403 (-4.2A)
ADP  A 403 (-3.0A)
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 1.15A 3w9tG-5ec0A:
undetectable		 3w9tG-5ec0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 5 THR A 293
ILE A 296
LYS A 297
PHE A 260
 None
 1.48A 4ac9C-5ec0A:
undetectable		 4ac9C-5ec0A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		3 / 3 LYS A 231
LYS A 321
ALA A 225
 None
 1.22A 4ot2A-5ec0A:
undetectable		 4ot2A-5ec0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 7 GLU A  73
SER A  13
GLU A 267
ASP A 218
 None
ADP  A 403 (-4.1A)
ADP  A 403 (-3.6A)
None
 1.27A 4uacA-5ec0A:
undetectable		 4uacA-5ec0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5ec0 ALP7A
(Bacillus
subtilis) 		3 / 3 ASN A 313
ALA A 309
ARG A 346
 None
 0.74A 5cvtB-5ec0A:
undetectable		 5cvtB-5ec0A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 6 TYR A  15
PHE A 101
ASP A   9
GLY A  11
 None
None
MG  A 404 ( 4.1A)
ADP  A 403 (-3.5A)
 1.13A 5mraA-5ec0A:
undetectable
5mraB-5ec0A:
undetectable		 5mraA-5ec0A:
20.11
5mraB-5ec0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ec0 ALP7A
(Bacillus
subtilis) 		4 / 6 SER A  13
ASP A   9
GLU A 180
THR A 217
 ADP  A 403 (-4.1A)
MG  A 404 ( 4.1A)
MG  A 404 (-4.2A)
None
 1.12A 6djzA-5ec0A:
undetectable		 6djzA-5ec0A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5ec0 ALP7A
(Bacillus
subtilis) 		3 / 3 THR A 217
GLU A 267
ASN A  12
 None
ADP  A 403 (-3.6A)
ADP  A 403 (-3.6A)
 0.88A 6nj9K-5ec0A:
undetectable		 6nj9K-5ec0A:
21.48