SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ec3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 5 TYR A 160
SER A  72
SER A  59
THR A  23
 TYR  A 160 ( 1.3A)
SER  A  72 ( 0.0A)
SER  A  59 ( 0.0A)
THR  A  23 ( 0.8A)
 1.19A 1yvpA-5ec3A:
undetectable		 1yvpA-5ec3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 6 TYR A 160
SER A  72
SER A  59
THR A  23
 TYR  A 160 ( 1.3A)
SER  A  72 ( 0.0A)
SER  A  59 ( 0.0A)
THR  A  23 ( 0.8A)
 1.17A 1yvpB-5ec3A:
undetectable		 1yvpB-5ec3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		5 / 12 LEU A  50
SER A  54
ASP A  91
ALA A  29
ALA A  32
 LEU  A  50 ( 0.6A)
SER  A  54 ( 0.0A)
ASP  A  91 ( 0.6A)
ALA  A  29 ( 0.0A)
ALA  A  32 ( 0.0A)
 1.09A 2bm9A-5ec3A:
undetectable		 2bm9A-5ec3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		3 / 3 PHE A 364
VAL A 212
TRP A 210
 PHE  A 364 ( 1.3A)
VAL  A 212 ( 0.6A)
TRP  A 210 ( 0.5A)
 0.86A 2cc8A-5ec3A:
undetectable		 2cc8A-5ec3A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		3 / 3 PHE A 364
VAL A 212
TRP A 210
 PHE  A 364 ( 1.3A)
VAL  A 212 ( 0.6A)
TRP  A 210 ( 0.5A)
 0.85A 2ccbA-5ec3A:
undetectable		 2ccbA-5ec3A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		3 / 3 PHE A 364
VAL A 212
TRP A 210
 PHE  A 364 ( 1.3A)
VAL  A 212 ( 0.6A)
TRP  A 210 ( 0.5A)
 0.84A 2vx9A-5ec3A:
undetectable		 2vx9A-5ec3A:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 ILE A 267
ILE A 274
LEU A 346
LEU A 367
 ILE  A 267 ( 0.6A)
ILE  A 274 ( 0.7A)
LEU  A 346 ( 0.6A)
LEU  A 367 ( 0.6A)
 0.71A 3adxA-5ec3A:
undetectable		 3adxA-5ec3A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 VAL A  70
SER A  21
HIS A  20
LEU A 157
 VAL  A  70 ( 0.6A)
SER  A  21 ( 0.0A)
HIS  A  20 ( 1.0A)
LEU  A 157 ( 0.6A)
 1.07A 3arrA-5ec3A:
undetectable		 3arrA-5ec3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		5 / 12 THR A 337
HIS A 266
LEU A 269
HIS A 183
LEU A 367
 THR  A 337 ( 0.8A)
HIS  A 266 (-1.0A)
LEU  A 269 ( 0.6A)
HIS  A 183 (-1.0A)
LEU  A 367 ( 0.6A)
 1.29A 3gwxA-5ec3A:
undetectable		 3gwxA-5ec3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		5 / 12 THR A 337
HIS A 266
LEU A 269
HIS A 183
LEU A 367
 THR  A 337 ( 0.8A)
HIS  A 266 (-1.0A)
LEU  A 269 ( 0.6A)
HIS  A 183 (-1.0A)
LEU  A 367 ( 0.6A)
 1.33A 3gwxB-5ec3A:
undetectable		 3gwxB-5ec3A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 LEU A 367
PRO A 239
SER A 226
GLY A 358
 LEU  A 367 ( 0.6A)
PRO  A 239 ( 1.1A)
SER  A 226 ( 0.0A)
GLY  A 358 ( 0.0A)
 1.07A 3hcnA-5ec3A:
undetectable		 3hcnA-5ec3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 5 LEU A 323
HIS A 183
GLU A 349
HIS A 266
 LEU  A 323 ( 0.6A)
HIS  A 183 (-1.0A)
GLU  A 349 (-0.6A)
HIS  A 266 (-1.0A)
 1.32A 4a7bB-5ec3A:
undetectable		 4a7bB-5ec3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 8 ASP A 182
VAL A 228
LEU A 332
HIS A 183
 ASP  A 182 ( 0.6A)
VAL  A 228 ( 0.6A)
LEU  A 332 ( 0.6A)
HIS  A 183 (-1.0A)
 1.18A 4f5zA-5ec3A:
undetectable		 4f5zA-5ec3A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 8 LEU A 367
PRO A 239
SER A 226
GLY A 358
 LEU  A 367 ( 0.6A)
PRO  A 239 ( 1.1A)
SER  A 226 ( 0.0A)
GLY  A 358 ( 0.0A)
 0.94A 4klrB-5ec3A:
undetectable		 4klrB-5ec3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 7 TYR A 295
GLY A 362
SER A 366
LEU A 367
 TYR  A 295 ( 1.3A)
GLY  A 362 ( 0.0A)
SER  A 366 ( 0.0A)
LEU  A 367 ( 0.6A)
 1.10A 5bphB-5ec3A:
undetectable		 5bphB-5ec3A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 4 ILE A 322
ILE A 278
ARG A 282
LEU A 323
 ILE  A 322 ( 0.6A)
ILE  A 278 ( 0.6A)
ARG  A 282 ( 0.6A)
LEU  A 323 ( 0.6A)
 1.16A 5dzkh-5ec3A:
undetectable
5dzkn-5ec3A:
undetectable
5dzkv-5ec3A:
undetectable		 5dzkh-5ec3A:
19.05
5dzkn-5ec3A:
19.05
5dzkv-5ec3A:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 4 ALA A 316
ASN A 313
ARG A 279
ILE A 275
 ALA  A 316 ( 0.0A)
ASN  A 313 ( 0.6A)
ARG  A 279 ( 0.6A)
ILE  A 275 ( 0.7A)
 1.16A 5eumB-5ec3A:
undetectable		 5eumB-5ec3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		5 / 12 PHE A  42
LEU A 346
PHE A  69
LEU A 178
LEU A 286
 PHE  A  42 ( 1.3A)
LEU  A 346 ( 0.6A)
PHE  A  69 ( 1.3A)
LEU  A 178 ( 0.6A)
LEU  A 286 ( 0.6A)
 1.35A 5y2oA-5ec3A:
undetectable		 5y2oA-5ec3A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Homo
sapiens) 		4 / 8 HIS A  20
PHE A  69
PHE A  42
LEU A 348
 HIS  A  20 ( 1.0A)
PHE  A  69 ( 1.3A)
PHE  A  42 ( 1.3A)
LEU  A 348 ( 0.6A)
 1.11A 5y2tB-5ec3A:
undetectable		 5y2tB-5ec3A:
undetectable