SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ecj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7Q_A_BEZA600_0
(COCAINE ESTERASE)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		5 / 10 TYR A 172
ALA A 205
PHE A 121
LEU A 118
PHE A 113
 None
 1.48A 1l7qA-5ecjA:
0.0		 1l7qA-5ecjA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		4 / 6 ILE A 122
GLN A 149
GLU A 111
TYR A 176
 None
 1.30A 2ya7C-5ecjA:
undetectable		 2ya7C-5ecjA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		4 / 7 SER A 127
TYR A 133
VAL A 134
TRP A 130
 None
 1.15A 3bu1A-5ecjA:
undetectable		 3bu1A-5ecjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		3 / 3 GLN A 149
PHE A 113
TYR A 176
 None
 0.87A 3ucjB-5ecjA:
undetectable		 3ucjB-5ecjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		3 / 3 GLN A 149
PHE A 113
TYR A 176
 None
 0.92A 3ucjA-5ecjA:
undetectable		 3ucjA-5ecjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		5 / 12 LEU A 211
ASN A 273
GLN A 278
LEU A 240
THR A 202
 None
 1.46A 4p6xA-5ecjA:
undetectable		 4p6xA-5ecjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		4 / 5 VAL A  85
LEU A  60
CYH A  77
ASP A 161
 None
 1.27A 5vcvA-5ecjA:
undetectable		 5vcvA-5ecjA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		3 / 3 LYS A 178
PRO A 183
LYS A 210
 None
 1.32A 5y9yA-5ecjA:
undetectable		 5y9yA-5ecjA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5ecj MONOBODY MB(S4)
(Homo
sapiens) 		4 / 7 ILE F  70
VAL F  10
ALA F  13
THR F  14
 None
 0.98A 6cduC-5ecjF:
undetectable
6cduD-5ecjF:
undetectable		 6cduC-5ecjF:
16.67
6cduD-5ecjF:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2
(Mus
musculus) 		4 / 5 TYR A 176
LYS A 178
GLY A  88
ILE A 154
 None
 1.31A 6debB-5ecjA:
undetectable		 6debB-5ecjA:
17.84