SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ecu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 5 ILE A 359
ILE A 371
ILE A 376
LEU A 306
 MLI  A 633 (-3.9A)
None
None
None
 0.89A 1zgyA-5ecuA:
undetectable		 1zgyA-5ecuA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 PRO A 231
THR A 197
PRO A 191
 None
 0.86A 2d55C-5ecuA:
undetectable		 2d55C-5ecuA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 ASN A 222
ASN A 177
ARG A  55
 None
None
EDO  A 602 (-4.7A)
 0.92A 2rlcA-5ecuA:
undetectable		 2rlcA-5ecuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ASN A 187
GLU A 188
HIS A 255
GLU A 285
TRP A 319
 CA  A 643 ( 4.8A)
CA  A 643 (-2.5A)
None
CA  A 643 ( 2.9A)
EDO  A 614 (-3.6A)
 0.55A 2v3dA-5ecuA:
16.2		 2v3dA-5ecuA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 TYR A 257
GLU A 188
ASN A 152
 EDO  A 614 (-4.1A)
CA  A 643 (-2.5A)
None
 0.88A 2y7hC-5ecuA:
undetectable		 2y7hC-5ecuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ARG A 110
GLU A 184
TYR A 257
ASN A 187
HIS A 149
 None
None
EDO  A 614 (-4.1A)
CA  A 643 ( 4.8A)
None
 1.47A 3bjmA-5ecuA:
undetectable		 3bjmA-5ecuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ARG A 110
GLU A 184
TYR A 257
ASN A 187
HIS A 149
 None
None
EDO  A 614 (-4.1A)
CA  A 643 ( 4.8A)
None
 1.45A 3bjmB-5ecuA:
undetectable		 3bjmB-5ecuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 GLY A 229
ASP A 147
HIS A 149
ARG A 236
SER A 234
 None
None
None
EDO  A 617 (-3.2A)
None
 1.39A 3dlcA-5ecuA:
undetectable		 3dlcA-5ecuA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 HIS A 149
PHE A 167
PHE A 168
 None
 0.58A 3lk0D-5ecuA:
undetectable		 3lk0D-5ecuA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ARG A 110
GLU A 184
TYR A 257
ASN A 187
HIS A 149
 None
None
EDO  A 614 (-4.1A)
CA  A 643 ( 4.8A)
None
 1.46A 3w2tA-5ecuA:
undetectable		 3w2tA-5ecuA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ARG A 110
GLU A 184
TYR A 257
ASN A 187
HIS A 149
 None
None
EDO  A 614 (-4.1A)
CA  A 643 ( 4.8A)
None
 1.41A 3w2tB-5ecuA:
undetectable		 3w2tB-5ecuA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 HIS A 255
GLU A 285
ASP A 147
SER A  81
 None
CA  A 643 ( 2.9A)
None
None
 1.06A 4apjA-5ecuA:
undetectable
4apjP-5ecuA:
undetectable		 4apjA-5ecuA:
20.57
4apjP-5ecuA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 GLY A 296
GLY A 361
GLU A 362
TYR A 363
 None
None
EDO  A 623 ( 4.9A)
None
 0.86A 4dxuA-5ecuA:
undetectable		 4dxuA-5ecuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 LEU A 151
ASN A 187
CYH A 186
TYR A 257
GLY A 229
 EDO  A 614 ( 4.7A)
CA  A 643 ( 4.8A)
None
EDO  A 614 (-4.1A)
None
 1.23A 4ot2A-5ecuA:
undetectable		 4ot2A-5ecuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 5 ASN A 187
HIS A 149
GLU A 184
THR A 284
 CA  A 643 ( 4.8A)
None
None
None
 1.41A 4p6sA-5ecuA:
undetectable		 4p6sA-5ecuA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 4 THR A 322
GLY A 293
ASP A 294
SER A 320
 None
EDO  A 614 (-3.6A)
None
None
 1.26A 4rfqA-5ecuA:
undetectable		 4rfqA-5ecuA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 ARG A 365
ASP A 103
TRP A 104
 GOL  A 628 (-3.9A)
EDO  A 604 ( 3.5A)
None
 1.22A 4xdqA-5ecuA:
undetectable		 4xdqA-5ecuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 LEU A 151
ASN A 187
CYH A 186
TYR A 257
GLY A 229
 EDO  A 614 ( 4.7A)
CA  A 643 ( 4.8A)
None
EDO  A 614 (-4.1A)
None
 1.22A 4zbrA-5ecuA:
undetectable		 4zbrA-5ecuA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 9 SER A  81
GLY A 229
SER A 234
ASN A 187
ALA A 210
 None
None
None
CA  A 643 ( 4.8A)
None
 1.38A 5entC-5ecuA:
undetectable		 5entC-5ecuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 9 SER A  81
GLY A 229
SER A 234
GLU A 188
ALA A 210
 None
None
None
CA  A 643 (-2.5A)
None
 1.35A 5entC-5ecuA:
undetectable		 5entC-5ecuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ALA A 302
LEU A 299
GLY A 287
SER A 289
PRO A 297
 None
ACT  A 636 (-4.3A)
None
None
None
 1.32A 5jglA-5ecuA:
undetectable		 5jglA-5ecuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ALA A 302
LEU A 299
GLY A 287
SER A 289
PRO A 297
 None
ACT  A 636 (-4.3A)
None
None
None
 1.35A 5jglB-5ecuA:
undetectable		 5jglB-5ecuA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 LEU A 344
LEU A 100
GLY A 329
ALA A 330
SER A 320
 None
 1.04A 5jvzA-5ecuA:
undetectable		 5jvzA-5ecuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 LEU A 344
LEU A 100
GLY A 329
ALA A 330
SER A 320
 None
 1.07A 5jvzB-5ecuA:
0.8		 5jvzB-5ecuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 6 GLY A 287
THR A 288
SER A 289
ASN A 318
 None
 0.82A 5k4pA-5ecuA:
1.8		 5k4pA-5ecuA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		4 / 7 TYR A  33
ASP A 303
LEU A 299
VAL A 364
 ACT  A 636 (-4.3A)
ACT  A 636 (-3.5A)
ACT  A 636 (-4.3A)
None
 0.95A 5ov9A-5ecuA:
undetectable		 5ov9A-5ecuA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 ARG A 367
PRO A 372
TYR A  38
 None
 1.08A 5tzoB-5ecuA:
undetectable		 5tzoB-5ecuA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 GLU A 362
TYR A 363
ARG A 367
 EDO  A 623 ( 4.9A)
None
None
 0.86A 5uunA-5ecuA:
undetectable		 5uunA-5ecuA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 THR A 284
GLU A 184
HIS A 149
 None
 0.90A 5xioA-5ecuA:
undetectable		 5xioA-5ecuA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 THR A 284
GLU A 184
HIS A 149
 None
 0.84A 5xiqB-5ecuA:
undetectable		 5xiqB-5ecuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		3 / 3 THR A 284
GLU A 184
HIS A 149
 None
 0.85A 5xiqD-5ecuA:
undetectable		 5xiqD-5ecuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ARG A 110
GLU A 184
TYR A 257
ASN A 187
HIS A 149
 None
None
EDO  A 614 (-4.1A)
CA  A 643 ( 4.8A)
None
 1.43A 6b1eB-5ecuA:
undetectable		 6b1eB-5ecuA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5ecu CELLULASE
(Caldicellulosiru
ptor
saccharolyticus) 		5 / 12 ILE A 227
THR A 284
ILE A 134
VAL A 130
ILE A 181
 None
 1.04A 6emuB-5ecuA:
2.0		 6emuB-5ecuA:
15.32