SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ed1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		3 / 3 ARG A 405
ILE A 609
TRP A 602
 None
 1.21A 1m8eB-5ed1A:
undetectable		 1m8eB-5ed1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 8 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.07A 1uyuB-5ed1A:
undetectable		 1uyuB-5ed1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		3 / 3 ASP A 606
GLU A 412
ARG A 423
 None
 0.60A 1wopA-5ed1A:
undetectable		 1wopA-5ed1A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 12 LEU A 556
ILE A 545
SER A 517
ILE A 520
ALA A 521
 None
 0.96A 2bxqA-5ed1A:
undetectable		 2bxqA-5ed1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 10 TYR A 668
ALA A 671
ILE A 528
ILE A 540
TYR A 541
 IHP  A 801 (-4.8A)
None
None
None
None
 1.30A 2dm6A-5ed1A:
undetectable
2dm6B-5ed1A:
undetectable		 2dm6A-5ed1A:
23.08
2dm6B-5ed1A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 12 TYR A 445
ILE A 528
GLY A 354
VAL A 331
SER A 599
 None
 0.97A 2okcA-5ed1A:
undetectable		 2okcA-5ed1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 5 LEU A 547
ALA A 324
ILE A 584
SER A 328
 None
 1.10A 2othA-5ed1A:
undetectable		 2othA-5ed1A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 12 HIS A 555
ASP A 453
GLU A 466
SER A 306
ASP A 554
 None
 1.37A 2pgfA-5ed1A:
undetectable		 2pgfA-5ed1A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 12 ILE A 425
LEU A 415
PHE A 434
PHE A 426
LEU A 533
 None
 1.32A 2w3mB-5ed1A:
undetectable		 2w3mB-5ed1A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		3 / 3 LYS A 334
LYS A 367
VAL A 368
 None
 1.05A 3brfA-5ed1A:
undetectable		 3brfA-5ed1A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		3 / 3 ARG A 405
ILE A 609
TRP A 602
 None
 1.17A 3e68A-5ed1A:
undetectable		 3e68A-5ed1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		3 / 3 ARG A 405
ILE A 609
TRP A 602
 None
 1.19A 3e6tB-5ed1A:
undetectable		 3e6tB-5ed1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.11A 3fwgA-5ed1A:
undetectable		 3fwgA-5ed1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		3 / 3 THR A 448
SER A 449
ARG A 455
 None
 0.64A 3phnA-5ed1A:
undetectable		 3phnA-5ed1A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 12 GLU A 396
ILE A 446
SER A 447
GLY A 548
GLU A 588
 ZN  A 802 ( 4.2A)
None
None
None
None
 1.40A 3r75A-5ed1A:
undetectable		 3r75A-5ed1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 12 GLU A 396
ILE A 446
SER A 447
GLY A 548
GLU A 588
 ZN  A 802 ( 4.2A)
None
None
None
None
 1.40A 3r75B-5ed1A:
undetectable		 3r75B-5ed1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 11 GLU A 396
ILE A 446
SER A 447
GLY A 548
GLU A 588
 ZN  A 802 ( 4.2A)
None
None
None
None
 1.39A 3r76A-5ed1A:
undetectable		 3r76A-5ed1A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 12 GLY A 354
ARG A 348
GLY A 333
ALA A 347
SER A 344
 None
G  C   5 ( 3.2A)
None
None
None
 1.02A 3sudA-5ed1A:
undetectable		 3sudA-5ed1A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.07A 3wrhE-5ed1A:
undetectable		 3wrhE-5ed1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.10A 3wrjE-5ed1A:
undetectable		 3wrjE-5ed1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.12A 4ek1A-5ed1A:
undetectable		 4ek1A-5ed1A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 ARG A 563
ILE A 567
VAL A 525
LEU A 675
 None
 1.11A 4em2A-5ed1A:
undetectable		 4em2A-5ed1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.14A 4g3rA-5ed1A:
undetectable		 4g3rA-5ed1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.12A 4g3rB-5ed1A:
undetectable		 4g3rB-5ed1A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		5 / 12 ASP A 392
VAL A 355
LEU A 444
ILE A 520
THR A 513
 None
None
None
None
IHP  A 801 (-4.1A)
 1.10A 4km2B-5ed1A:
undetectable		 4km2B-5ed1A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 5 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.11A 4l49A-5ed1A:
undetectable		 4l49A-5ed1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 PHE A 406
LEU A 436
VAL A 440
VAL A 355
 None
 1.13A 4l4cA-5ed1A:
undetectable		 4l4cA-5ed1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 6 LEU A 323
SER A 543
PRO A 579
PHE A 542
 None
 1.10A 5b8iA-5ed1A:
undetectable		 5b8iA-5ed1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1
(Homo
sapiens) 		4 / 8 THR A 373
SER A 399
SER A 402
SER A 625
 None
 1.12A 5l5fY-5ed1A:
undetectable
5l5fZ-5ed1A:
undetectable		 5l5fY-5ed1A:
19.45
5l5fZ-5ed1A:
20.95