SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ed4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 183
ASP A 117
TYR A 118
GLU A 160
 None
 1.32A 1rjdA-5ed4A:
undetectable		 1rjdA-5ed4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 183
ASP A 117
TYR A 118
GLU A 160
 None
 1.33A 1rjdC-5ed4A:
undetectable		 1rjdC-5ed4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 133
ILE A 187
ASN A 188
GLN A  43
 None
 1.10A 2jc9A-5ed4A:
2.4		 2jc9A-5ed4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 7 THR A 180
ILE A 187
ASN A 188
GLN A  43
 None
 1.10A 2jc9A-5ed4A:
2.4		 2jc9A-5ed4A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 136
LEU A 132
SER A  37
LEU A  40
LYS A  41
 None
 1.07A 2xn5A-5ed4A:
undetectable		 2xn5A-5ed4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  70
GLY A  53
ALA A  56
ALA A  60
LEU A  24
 None
EDO  A 303 (-3.7A)
None
None
None
 1.13A 3p5nA-5ed4A:
undetectable		 3p5nA-5ed4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  70
GLY A  53
ALA A  56
ALA A  60
LEU A  24
 None
EDO  A 303 (-3.7A)
None
None
None
 1.13A 3p5nB-5ed4A:
undetectable		 3p5nB-5ed4A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 135
LYS A 121
PHE A  97
GLY A  79
 None
CA  A 301 ( 3.8A)
None
None
 1.14A 3sj0X-5ed4A:
undetectable		 3sj0X-5ed4A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 231
VAL A 218
LEU A 221
SER A 219
 None
 1.20A 4e1gA-5ed4A:
undetectable		 4e1gA-5ed4A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  94
GLY A 115
ASP A  27
ASP A 117
 None
None
CA  A 301 ( 4.3A)
None
 1.05A 4n48B-5ed4A:
2.5		 4n48B-5ed4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 225
LEU A 233
GLU A 178
VAL A 213
 None
 1.07A 4nkxB-5ed4A:
undetectable		 4nkxB-5ed4A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5ed4 RESPONSE REGULATOR
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 151
VAL A 202
GLU A 127
SER A 124
 None
 1.28A 5umwA-5ed4A:
undetectable
5umwF-5ed4A:
undetectable		 5umwA-5ed4A:
16.06
5umwF-5ed4A:
16.06