SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ed7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 11 LEU A 488
LEU A 466
ALA A 475
LEU A 463
THR A 479
 None
 1.26A 1ictA-5ed7A:
undetectable
1ictC-5ed7A:
undetectable		 1ictA-5ed7A:
18.65
1ictC-5ed7A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 12 LEU A 402
LEU A 444
PHE A 398
GLY A 507
ALA A 509
 None
 1.10A 2aylA-5ed7A:
undetectable		 2aylA-5ed7A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 10 ALA A 401
ALA A 404
LEU A 459
LEU A 435
VAL A 520
 None
 1.00A 2bxeA-5ed7A:
2.5		 2bxeA-5ed7A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 10 ALA A 401
ALA A 404
LEU A 459
LEU A 435
VAL A 520
 None
 1.02A 2bxgB-5ed7A:
2.4		 2bxgB-5ed7A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 9 PHE A 326
SER A 343
ALA A 349
LEU A 348
ALA A 322
 None
 1.48A 2wsfB-5ed7A:
undetectable		 2wsfB-5ed7A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		3 / 3 ARG A 319
GLY A 317
SER A 529
 None
 0.60A 2xctB-5ed7A:
undetectable		 2xctB-5ed7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 4 PRO A 418
TYR A 458
GLY A 484
THR A 486
 None
 1.43A 3ib0A-5ed7A:
undetectable		 3ib0A-5ed7A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 12 TYR A 351
LEU A 397
LEU A 466
PHE A 326
ALA A 430
 None
 0.86A 3vw7A-5ed7A:
undetectable		 3vw7A-5ed7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 6 ALA A 461
PRO A 418
LEU A 482
THR A 483
 None
 0.94A 4dtzA-5ed7A:
undetectable		 4dtzA-5ed7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 6 ALA A 461
PRO A 418
LEU A 482
THR A 483
 None
 0.93A 4dtzB-5ed7A:
undetectable		 4dtzB-5ed7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 7 ALA A 461
PRO A 418
LEU A 482
THR A 483
 None
 0.92A 4du2A-5ed7A:
undetectable		 4du2A-5ed7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 7 ALA A 461
PRO A 418
LEU A 482
THR A 483
 None
 0.92A 4du2B-5ed7A:
undetectable		 4du2B-5ed7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 8 PHE A 501
ASN A 395
ALA A 393
LEU A 287
 None
 0.89A 4ejgB-5ed7A:
undetectable		 4ejgB-5ed7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 6 PHE A 501
ASN A 395
ALA A 393
LEU A 287
 None
 0.96A 4ejgD-5ed7A:
0.7		 4ejgD-5ed7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 495
ASP A 494
ALA A 403
PHE A 462
LEU A 488
 None
 1.15A 5nd2B-5ed7A:
undetectable		 5nd2B-5ed7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 495
ASP A 494
ALA A 403
PHE A 462
LEU A 488
 None
 1.19A 5nd4B-5ed7A:
undetectable		 5nd4B-5ed7A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 12 VAL A 495
ASP A 494
ALA A 403
PHE A 462
LEU A 488
 None
 1.22A 5nd7B-5ed7A:
undetectable		 5nd7B-5ed7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		5 / 12 ILE A 355
ILE A 336
LEU A 522
LEU A 348
LEU A 325
 None
 1.15A 5tiwA-5ed7A:
undetectable		 5tiwA-5ed7A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5ed7 TEGUMENT PROTEIN
UL21
(Human
alphaherpesvirus
1) 		4 / 4 VAL A 428
LEU A 463
LEU A 466
ASP A 400
 None
 1.37A 5xv7A-5ed7A:
undetectable		 5xv7A-5ed7A:
16.32