SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ed8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 GLY A 695
ARG A 602
MET A 528
PHE A 661
 None
 1.07A 1gsfA-5ed8A:
undetectable		 1gsfA-5ed8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 GLY A 695
ARG A 602
MET A 528
PHE A 661
 None
 1.07A 1gsfB-5ed8A:
undetectable		 1gsfB-5ed8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 GLY A 695
ARG A 602
MET A 528
PHE A 661
 None
 1.07A 1gsfD-5ed8A:
undetectable		 1gsfD-5ed8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 6 SER A 616
ILE A 621
ALA A 624
ALA A 585
 None
 0.95A 1w0gA-5ed8A:
undetectable		 1w0gA-5ed8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		3 / 3 THR A 678
PRO A 625
PRO A 589
 None
 0.80A 2d55C-5ed8A:
undetectable		 2d55C-5ed8A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		3 / 3 PRO A 589
THR A 678
PRO A 625
 None
 0.76A 2d55C-5ed8A:
undetectable		 2d55C-5ed8A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.86A 2eijN-5ed8A:
undetectable
2eijW-5ed8A:
undetectable		 2eijN-5ed8A:
19.08
2eijW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.88A 2eikN-5ed8A:
undetectable
2eikW-5ed8A:
undetectable		 2eikN-5ed8A:
19.08
2eikW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.86A 2eilN-5ed8A:
undetectable
2eilW-5ed8A:
undetectable		 2eilN-5ed8A:
19.08
2eilW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		5 / 12 LEU A 574
ALA A 593
ILE A 688
ILE A 676
ILE A 573
 None
 0.89A 2hs1B-5ed8A:
undetectable		 2hs1B-5ed8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 5 GLU A 696
PRO A 697
ILE A 601
GLY A 695
 None
 1.19A 2qeuA-5ed8A:
undetectable
2qeuC-5ed8A:
undetectable		 2qeuA-5ed8A:
23.14
2qeuC-5ed8A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 7 ILE A 630
LEU A 644
PHE A 661
ARG A 692
 None
 1.05A 3ag2N-5ed8A:
undetectable
3ag2W-5ed8A:
undetectable		 3ag2N-5ed8A:
19.08
3ag2W-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.86A 3asnN-5ed8A:
undetectable
3asnW-5ed8A:
undetectable		 3asnN-5ed8A:
19.08
3asnW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		6 / 12 ILE A 474
ALA A 517
PHE A 559
LEU A 563
PRO A 562
LEU A 467
 None
 1.43A 4m2xA-5ed8A:
undetectable		 4m2xA-5ed8A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		5 / 11 VAL A 611
ASN A 618
TYR A 685
ALA A 624
SER A 623
 None
 1.48A 4m83B-5ed8A:
undetectable		 4m83B-5ed8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		5 / 12 LEU A 574
ALA A 593
ILE A 688
ILE A 676
ILE A 573
 None
 0.94A 4q1yB-5ed8A:
undetectable		 4q1yB-5ed8A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 6 ILE A 630
LEU A 644
PHE A 661
ARG A 692
 None
 0.95A 5b1aN-5ed8A:
undetectable
5b1aW-5ed8A:
undetectable		 5b1aN-5ed8A:
19.08
5b1aW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 7 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.71A 5b1bN-5ed8A:
undetectable
5b1bW-5ed8A:
undetectable		 5b1bN-5ed8A:
19.08
5b1bW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 7 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.85A 5b3sN-5ed8A:
undetectable
5b3sW-5ed8A:
undetectable		 5b3sN-5ed8A:
19.08
5b3sW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.90A 5xdxN-5ed8A:
undetectable
5xdxW-5ed8A:
undetectable		 5xdxN-5ed8A:
19.08
5xdxW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.77A 5zcqN-5ed8A:
undetectable
5zcqW-5ed8A:
undetectable		 5zcqN-5ed8A:
19.08
5zcqW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 8 ILE A 688
VAL A 693
ARG A 690
ASP A 524
 None
 0.95A 6hu9a-5ed8A:
undetectable
6hu9e-5ed8A:
undetectable		 6hu9a-5ed8A:
19.40
6hu9e-5ed8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ed8 MKIAA0668 PROTEIN
(Mus
musculus) 		4 / 5 ILE A 630
LEU A 644
ARG A 692
LEU A 597
 None
 0.93A 6nmpN-5ed8A:
undetectable
6nmpW-5ed8A:
undetectable		 6nmpN-5ed8A:
19.08
6nmpW-5ed8A:
13.46