SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5edl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 10 LYS A 165
LEU A 182
GLU A 185
LEU A 186
LYS A 189
 None
 0.99A 1cqpA-5edlA:
undetectable
1cqpB-5edlA:
undetectable		 1cqpA-5edlA:
22.07
1cqpB-5edlA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		4 / 7 PHE A  50
SER A 155
ALA A 160
ILE A  51
 None
 1.01A 1fxhA-5edlA:
1.1
1fxhB-5edlA:
undetectable		 1fxhA-5edlA:
23.18
1fxhB-5edlA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		4 / 8 SER A 127
ILE A  91
GLY A  92
GLY A 120
 None
VIB  A 201 ( 4.2A)
VIB  A 201 ( 4.6A)
None
 0.73A 1me7A-5edlA:
undetectable		 1me7A-5edlA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 11 SER A 168
LEU A 116
VAL A 115
PHE A 103
VAL A  54
 None
 1.30A 1q23J-5edlA:
undetectable		 1q23J-5edlA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 10 SER A 168
LEU A 116
VAL A 115
PHE A 103
VAL A  54
 None
 1.45A 1q23K-5edlA:
undetectable		 1q23K-5edlA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		4 / 6 ALA A 172
TYR A 173
ASP A 169
TYR A  58
 None
 1.48A 2pncB-5edlA:
undetectable		 2pncB-5edlA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		6 / 12 GLY A  64
ALA A  65
ILE A  55
VAL A  52
ILE A  72
ILE A  60
 MPG  A 202 ( 3.2A)
None
None
None
None
None
 1.22A 3ekqA-5edlA:
undetectable		 3ekqA-5edlA:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 10 SER A  53
VAL A 102
SER A 123
GLY A 120
GLY A 122
 None
None
None
None
MPG  A 203 ( 4.7A)
 1.50A 3ixlA-5edlA:
undetectable		 3ixlA-5edlA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		3 / 3 LYS A  62
PRO A  63
LYS A   3
 None
MPG  A 202 ( 4.3A)
None
 1.36A 4dr5L-5edlA:
undetectable		 4dr5L-5edlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		3 / 3 LYS A  62
PRO A  63
LYS A   3
 None
MPG  A 202 ( 4.3A)
None
 1.42A 4dr6L-5edlA:
undetectable		 4dr6L-5edlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 10 ALA A 101
VAL A 102
SER A 124
SER A 123
GLY A  98
 MPG  A 202 (-2.8A)
None
None
None
MPG  A 203 ( 4.1A)
 1.39A 4xp1A-5edlA:
1.0		 4xp1A-5edlA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 12 GLY A 120
GLY A  96
GLY A  98
VAL A 102
ILE A  91
 None
None
MPG  A 203 ( 4.1A)
None
VIB  A 201 ( 4.2A)
 0.95A 5x7fA-5edlA:
undetectable		 5x7fA-5edlA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 12 ILE A  91
ALA A  57
ALA A  99
ALA A 119
PHE A 103
 VIB  A 201 ( 4.2A)
None
None
None
None
 0.89A 5zw4A-5edlA:
undetectable		 5zw4A-5edlA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 11 TYR A 130
VAL A  94
GLY A  98
ALA A 105
VAL A 125
 None
MPG  A 203 ( 4.8A)
MPG  A 203 ( 4.1A)
None
None
 1.20A 6hu9A-5edlA:
0.7
6hu9E-5edlA:
0.0
6hu9I-5edlA:
undetectable		 6hu9A-5edlA:
18.45
6hu9E-5edlA:
20.75
6hu9I-5edlA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5edl PUTATIVE
HMP/THIAMINE
PERMEASE PROTEIN
YKOE
(Bacillus
subtilis) 		5 / 10 TYR A 130
VAL A  94
GLY A  98
ALA A 105
VAL A 125
 None
MPG  A 203 ( 4.8A)
MPG  A 203 ( 4.1A)
None
None
 1.17A 6hu9L-5edlA:
undetectable
6hu9P-5edlA:
undetectable
6hu9T-5edlA:
undetectable		 6hu9L-5edlA:
18.45
6hu9P-5edlA:
20.75
6hu9T-5edlA:
14.89