SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ee4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 6 THR A 287
PHE A  42
PHE A 265
GLY A 263
 None
 1.11A 1icuA-5ee4A:
undetectable
1icuB-5ee4A:
undetectable		 1icuA-5ee4A:
22.29
1icuB-5ee4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 5 PHE A 265
GLY A 263
THR A 287
PHE A  42
 None
 1.23A 1icuC-5ee4A:
undetectable
1icuD-5ee4A:
undetectable		 1icuC-5ee4A:
22.29
1icuD-5ee4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 5 PHE A 265
GLY A 263
THR A 287
PHE A  42
 None
 1.19A 1icvA-5ee4A:
undetectable
1icvB-5ee4A:
undetectable		 1icvA-5ee4A:
22.29
1icvB-5ee4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 6 THR A 287
PHE A  42
PHE A 265
GLY A 263
 None
 1.17A 1kqbA-5ee4A:
undetectable
1kqbB-5ee4A:
undetectable		 1kqbA-5ee4A:
22.58
1kqbB-5ee4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 6 PHE A 265
GLY A 263
THR A 287
PHE A  42
 None
 1.06A 1kqbC-5ee4A:
undetectable
1kqbD-5ee4A:
undetectable		 1kqbC-5ee4A:
22.58
1kqbD-5ee4A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ee4 HPUA
(Kingella
denitrificans) 		3 / 3 ASN A 297
ILE A 225
MET A 237
 None
 0.72A 2h42C-5ee4A:
undetectable		 2h42C-5ee4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 8 ALA A 118
ALA A 140
SER A 149
GLY A  47
 None
 0.87A 2vh3B-5ee4A:
undetectable		 2vh3B-5ee4A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 5ee4 HPUA
(Kingella
denitrificans) 		5 / 12 GLY A 209
ASN A 297
VAL A 288
PHE A 290
ILE A 235
 None
 1.07A 3eluA-5ee4A:
undetectable		 3eluA-5ee4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 5 SER A 280
LYS A 267
LEU A 162
ASP A 160
 None
 1.45A 4ifxA-5ee4A:
undetectable		 4ifxA-5ee4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 5 SER A 280
LYS A 267
LEU A 162
ASP A 160
 None
 1.46A 4xdtA-5ee4A:
undetectable		 4xdtA-5ee4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5ee4 HPUA
(Kingella
denitrificans) 		3 / 3 ARG A 305
TYR A 194
GLU A 178
 None
 0.68A 4zzbE-5ee4A:
undetectable		 4zzbE-5ee4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 6 THR A 257
ALA A 251
THR A 250
VAL A 260
 None
 0.86A 5ecoA-5ee4A:
undetectable		 5ecoA-5ee4A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 6 SER A 210
GLY A 227
ASN A 228
ILE A 235
 None
 1.14A 5j4nA-5ee4A:
undetectable		 5j4nA-5ee4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 5ee4 HPUA
(Kingella
denitrificans) 		4 / 6 GLN A  39
ARG A  37
CYH A 120
THR A  88
 None
 1.34A 5mwyA-5ee4A:
undetectable		 5mwyA-5ee4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 5ee4 HPUA
(Kingella
denitrificans) 		5 / 12 VAL A 206
LEU A 221
VAL A 214
PHE A 247
GLY A 302
 None
 1.25A 6brdA-5ee4A:
undetectable		 6brdA-5ee4A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5ee4 HPUA
(Kingella
denitrificans) 		5 / 12 LEU A  89
PHE A 138
SER A 192
ILE A 180
THR A 303
 None
 1.26A 6debB-5ee4A:
undetectable		 6debB-5ee4A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5ee4 HPUA
(Kingella
denitrificans) 		5 / 9 ASP A 111
SER A 112
TYR A  81
GLY A 139
SER A 299
 None
 1.38A 6giqA-5ee4A:
undetectable
6giqE-5ee4A:
undetectable
6giqI-5ee4A:
undetectable		 6giqA-5ee4A:
21.43
6giqE-5ee4A:
21.39
6giqI-5ee4A:
13.44