SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ee5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		4 / 4 THR A 199
LEU A 202
VAL A 175
LEU A 172
 ALY  A 195 ( 3.5A)
CL  A 308 (-4.0A)
None
None
 0.91A 1mz9D-5ee5A:
undetectable		 1mz9D-5ee5A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 11 ALA A 174
ILE A 151
ILE A 131
ALA A 158
ALA A 154
 None
None
None
None
CL  A 312 (-3.4A)
 1.09A 2qhfA-5ee5A:
undetectable		 2qhfA-5ee5A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A  81
GLY A 114
CYH A 135
ILE A 134
CYH A  88
 None
 1.17A 3ko0A-5ee5A:
undetectable
3ko0C-5ee5A:
undetectable		 3ko0A-5ee5A:
20.59
3ko0C-5ee5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A  81
GLY A 114
CYH A 135
ILE A 134
CYH A  88
 None
 1.22A 3ko0L-5ee5A:
undetectable
3ko0N-5ee5A:
undetectable		 3ko0L-5ee5A:
20.59
3ko0N-5ee5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 10 GLY A 114
CYH A 135
ILE A 134
CYH A  88
PHE A  81
 None
 1.23A 3ko0R-5ee5A:
undetectable
3ko0T-5ee5A:
undetectable		 3ko0R-5ee5A:
20.59
3ko0T-5ee5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A  44
ALA A  40
LEU A  12
LEU A 106
LEU A 112
 None
 0.95A 3uvvA-5ee5A:
undetectable		 3uvvA-5ee5A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 MET A 209
PHE A 206
ILE A 131
ASP A 128
GLY A 169
 None
 1.45A 4djfA-5ee5A:
undetectable		 4djfA-5ee5A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		4 / 8 LEU A 126
LEU A 103
LYS A   8
TYR A  80
 None
 0.97A 5hbsA-5ee5A:
undetectable		 5hbsA-5ee5A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		4 / 6 ARG A 129
PHE A  81
ILE A 134
THR A 133
 None
 1.14A 5vceA-5ee5A:
undetectable		 5vceA-5ee5A:
18.28