SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ee7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A 242
HIS A 177
ILE A 176
 None
 0.66A 1s9pB-5ee7A:
undetectable		 1s9pB-5ee7A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 VAL A 285
VAL A 280
TRP A 282
 None
OLA  A1210 ( 4.5A)
None
 0.98A 1w5uC-5ee7A:
undetectable
1w5uD-5ee7A:
undetectable		 1w5uC-5ee7A:
4.11
1w5uD-5ee7A:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 GLY A 164
GLY A 165
LEU A 160
SER A 167
ASN A 174
 None
None
OLA  A1207 ( 4.0A)
None
None
 1.08A 1xdsA-5ee7A:
undetectable		 1xdsA-5ee7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 GLY A 164
GLY A 165
LEU A 160
SER A 167
ASN A 174
 None
None
OLA  A1207 ( 4.0A)
None
None
 1.06A 1xdsB-5ee7A:
undetectable		 1xdsB-5ee7A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		3 / 3 LEU A 252
LEU A 328
MET A 338
 None
 0.80A 1ya3B-5ee7A:
undetectable		 1ya3B-5ee7A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 ALA A1127
PHE A1151
LEU A1131
ALA A1128
ILE A1076
 None
 0.94A 2aclA-5ee7A:
2.3
2aclE-5ee7A:
2.2		 2aclA-5ee7A:
18.06
2aclE-5ee7A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A 316
ILE A 325
GLY A 246
HIS A 250
LEU A 247
 None
None
None
OLA  A1209 (-3.8A)
None
 1.22A 2j7xA-5ee7A:
undetectable		 2j7xA-5ee7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 5 ASN A 404
ALA A 178
LEU A 156
THR A 353
 5MV  A1201 (-3.5A)
None
None
5MV  A1201 (-3.8A)
 0.78A 3dl9A-5ee7A:
undetectable		 3dl9A-5ee7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 ALA A1127
PHE A1151
LEU A1131
ALA A1128
ILE A1076
 None
 1.02A 3falC-5ee7A:
undetectable		 3falC-5ee7A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 ALA A1127
PHE A1151
LEU A1131
ALA A1128
ILE A1076
 None
 0.97A 3fc6A-5ee7A:
2.3		 3fc6A-5ee7A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		3 / 3 VAL A 285
VAL A 280
TRP A 282
 None
OLA  A1210 ( 4.5A)
None
 0.90A 3l8lC-5ee7A:
undetectable
3l8lD-5ee7A:
undetectable		 3l8lC-5ee7A:
4.11
3l8lD-5ee7A:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 10 VAL A 279
VAL A 311
TYR A 233
ILE A 235
GLN A 232
 None
None
None
PE5  A1216 (-3.9A)
None
 1.25A 3retA-5ee7A:
1.5
3retB-5ee7A:
1.5		 3retA-5ee7A:
12.90
3retB-5ee7A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A 316
ILE A 325
GLY A 246
HIS A 250
LEU A 247
 None
None
None
OLA  A1209 (-3.8A)
None
 1.26A 4j26A-5ee7A:
undetectable		 4j26A-5ee7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
 None
PE5  A1216 (-4.7A)
None
None
None
 1.37A 4mmfA-5ee7A:
undetectable		 4mmfA-5ee7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 9 ALA A 237
TYR A 239
GLY A 393
PHE A 184
GLY A 234
 None
PE5  A1216 (-4.7A)
None
None
None
 1.40A 4mmfB-5ee7A:
undetectable		 4mmfB-5ee7A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 11 LEU A 316
ILE A 325
GLY A 246
HIS A 250
LEU A 247
 None
None
None
OLA  A1209 (-3.8A)
None
 1.22A 4pxmB-5ee7A:
undetectable		 4pxmB-5ee7A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		4 / 7 THR A1024
TYR A1016
GLU A1009
HIS A1029
 None
 1.01A 5ecnA-5ee7A:
undetectable		 5ecnA-5ee7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Escherichia
virus
T4;
Homo
sapiens) 		5 / 12 LEU A 388
LEU A 192
LEU A 394
GLY A 393
ALA A 154
 OLA  A1204 (-3.7A)
OLA  A1207 ( 4.5A)
OLA  A1204 ( 4.3A)
None
None
 1.32A 5j7wC-5ee7A:
undetectable		 5j7wC-5ee7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A 388
LEU A 192
LEU A 394
GLY A 393
ALA A 154
 OLA  A1204 (-3.7A)
OLA  A1207 ( 4.5A)
OLA  A1204 ( 4.3A)
None
None
 1.25A 6qxsD-5ee7A:
undetectable		 6qxsD-5ee7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A 388
LEU A 192
LEU A 394
GLY A 393
ALA A 154
 OLA  A1204 (-3.7A)
OLA  A1207 ( 4.5A)
OLA  A1204 ( 4.3A)
None
None
 1.30A 6qyaB-5ee7A:
undetectable		 6qyaB-5ee7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A 388
LEU A 192
LEU A 394
GLY A 393
ALA A 154
 OLA  A1204 (-3.7A)
OLA  A1207 ( 4.5A)
OLA  A1204 ( 4.3A)
None
None
 1.30A 6qyaD-5ee7A:
undetectable		 6qyaD-5ee7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5ee7 GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR
(Homo
sapiens;
Escherichia
virus
T4) 		5 / 12 LEU A 180
LEU A 249
GLY A 246
ASN A 318
ALA A 173
 None
 1.28A 6r2eH-5ee7A:
undetectable		 6r2eH-5ee7A:
20.51