SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 5eef HDAC6
(Danio
rerio) 		8 / 11 PRO A  83
HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.45A 1c3sA-5eefA:
41.3		 1c3sA-5eefA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5eef HDAC6
(Danio
rerio) 		5 / 11 GLY A 234
GLY A 191
GLY A 321
GLY A 361
ASP A 323
 None
None
None
TSN  A2002 ( 3.8A)
ZN  A2001 ( 2.7A)
 1.11A 1mxgA-5eefA:
undetectable		 1mxgA-5eefA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5eef HDAC6
(Danio
rerio) 		4 / 4 SER A 185
VAL A 108
PHE A  71
VAL A  89
 None
 1.49A 1o86A-5eefA:
undetectable		 1o86A-5eefA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 5eef HDAC6
(Danio
rerio) 		4 / 5 ILE A 401
TRP A 286
LEU A 398
PRO A 393
 None
 1.15A 1s8fA-5eefA:
undetectable
1s8fB-5eefA:
undetectable		 1s8fA-5eefA:
18.53
1s8fB-5eefA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		6 / 12 ASP A 149
HIS A 192
HIS A 193
GLY A 201
ASP A 230
HIS A 232
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
 1.34A 1t69A-5eefA:
41.5		 1t69A-5eefA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		8 / 12 HIS A 192
HIS A 193
GLY A 201
PHE A 202
ASP A 230
HIS A 232
ASP A 323
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.45A 1t69A-5eefA:
41.5		 1t69A-5eefA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 TYR A 152
HIS A 193
GLY A 201
HIS A 232
ASP A 323
 None
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
 1.40A 1t69A-5eefA:
41.5		 1t69A-5eefA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		4 / 5 LEU A 343
LEU A 305
LEU A 303
LEU A 347
 None
 1.16A 1yajD-5eefA:
undetectable		 1yajD-5eefA:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		5 / 11 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.14A 1zz1A-5eefA:
49.6		 1zz1A-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		8 / 11 HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.44A 1zz1A-5eefA:
49.6		 1zz1A-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		5 / 11 HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.01A 1zz1A-5eefA:
49.6		 1zz1A-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.17A 1zz1B-5eefA:
49.9
1zz1C-5eefA:
50.0		 1zz1B-5eefA:
32.32
1zz1C-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		8 / 12 HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.46A 1zz1B-5eefA:
49.9
1zz1C-5eefA:
50.0		 1zz1B-5eefA:
32.32
1zz1C-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.01A 1zz1B-5eefA:
49.9
1zz1C-5eefA:
50.0		 1zz1B-5eefA:
32.32
1zz1C-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		7 / 12 ASP A 149
HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 361
TYR A 363
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.12A 1zz1C-5eefA:
50.0		 1zz1C-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.15A 1zz1C-5eefA:
50.0		 1zz1C-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		8 / 12 HIS A 192
HIS A 193
GLY A 201
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.37A 1zz1C-5eefA:
50.0		 1zz1C-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.00A 1zz1C-5eefA:
50.0		 1zz1C-5eefA:
32.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZ1_D_SHHD2752_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5eef HDAC6
(Danio
rerio) 		7 / 9 HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.46A 1zz1D-5eefA:
49.8		 1zz1D-5eefA:
32.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 5eef HDAC6
(Danio
rerio) 		6 / 11 ALA A 211
ALA A 209
GLU A 360
SER A 167
LEU A 169
VAL A 165
 None
 1.42A 2bxeB-5eefA:
undetectable		 2bxeB-5eefA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5eef HDAC6
(Danio
rerio) 		4 / 7 PHE A  71
ARG A  73
ALA A 110
ASP A  69
 None
 1.23A 2e5dA-5eefA:
undetectable
2e5dB-5eefA:
undetectable		 2e5dA-5eefA:
21.26
2e5dB-5eefA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5eef HDAC6
(Danio
rerio) 		4 / 7 ASP A  69
PHE A  71
ARG A  73
ALA A 110
 None
 1.24A 2e5dA-5eefA:
undetectable
2e5dB-5eefA:
undetectable		 2e5dA-5eefA:
21.26
2e5dB-5eefA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5eef HDAC6
(Danio
rerio) 		5 / 12 VAL A 325
ILE A 342
LEU A 347
ALA A 374
SER A 375
 None
 1.31A 2iyfB-5eefA:
2.1		 2iyfB-5eefA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5eef HDAC6
(Danio
rerio) 		4 / 7 LEU A 208
ASN A 206
LEU A 120
TYR A 249
 None
 1.13A 2w8yA-5eefA:
undetectable		 2w8yA-5eefA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5eef HDAC6
(Danio
rerio) 		5 / 10 MET A 376
ALA A 320
ALA A 358
LEU A 171
VAL A  66
 None
 1.24A 2wuzA-5eefA:
undetectable		 2wuzA-5eefA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 5eef HDAC6
(Danio
rerio) 		5 / 10 MET A 376
ALA A 320
ALA A 358
LEU A 171
VAL A  66
 None
 1.23A 2wuzB-5eefA:
undetectable		 2wuzB-5eefA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 12 ASP A 328
PHE A 202
HIS A 192
GLY A 201
SER A 150
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.6A)
 1.33A 2y6rC-5eefA:
undetectable		 2y6rC-5eefA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_D_CTCD1385_0
(TETX2 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 10 ASP A 328
PHE A 202
HIS A 192
GLY A 201
SER A 150
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.6A)
 1.35A 2y6rD-5eefA:
0.0		 2y6rD-5eefA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 5eef HDAC6
(Danio
rerio) 		5 / 5 HIS A 192
HIS A 193
ASP A 230
HIS A 232
ASP A 323
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
 0.27A 3c0zA-5eefA:
54.2		 3c0zA-5eefA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5eef HDAC6
(Danio
rerio) 		5 / 8 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.27A 3c0zB-5eefA:
54.7		 3c0zB-5eefA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5eef HDAC6
(Danio
rerio) 		7 / 8 HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
 0.44A 3c0zB-5eefA:
54.7		 3c0zB-5eefA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5eef HDAC6
(Danio
rerio) 		5 / 6 ASP A 149
HIS A 192
HIS A 193
ASP A 230
HIS A 232
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
 1.31A 3c0zC-5eefA:
54.0		 3c0zC-5eefA:
35.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5eef HDAC6
(Danio
rerio) 		5 / 6 HIS A 192
HIS A 193
ASP A 230
HIS A 232
ASP A 323
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
 0.27A 3c0zC-5eefA:
54.0		 3c0zC-5eefA:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5eef HDAC6
(Danio
rerio) 		5 / 12 ILE A 240
ALA A 196
ASN A 207
VAL A 247
ILE A 226
 None
 1.04A 3e00A-5eefA:
undetectable		 3e00A-5eefA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5eef HDAC6
(Danio
rerio) 		4 / 7 VAL A 175
VAL A 168
ASN A 182
GLY A 183
 None
None
EDO  A2006 ( 4.1A)
None
 1.07A 3kmoB-5eefA:
undetectable		 3kmoB-5eefA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5eef HDAC6
(Danio
rerio) 		3 / 3 ALA A 209
ARG A 213
LYS A 217
 None
 1.11A 3kp5B-5eefA:
undetectable		 3kp5B-5eefA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 5eef HDAC6
(Danio
rerio) 		5 / 11 LEU A 102
VAL A 372
PHE A 184
LEU A  65
GLU A  97
 None
 1.49A 3m8pA-5eefA:
undetectable
3m8pB-5eefA:
undetectable		 3m8pA-5eefA:
20.24
3m8pB-5eefA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 11 ASP A 328
PHE A 202
HIS A 192
GLY A 201
SER A 150
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.6A)
 1.31A 3v3oC-5eefA:
undetectable		 3v3oC-5eefA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 11 ASN A 200
GLN A 235
HIS A 233
GLY A 236
GLY A 361
 None
None
None
None
TSN  A2002 ( 3.8A)
 1.38A 4a99C-5eefA:
1.3		 4a99C-5eefA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 10 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.30A 4bz6A-5eefA:
40.4		 4bz6A-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		8 / 10 HIS A 192
HIS A 193
ASP A 230
HIS A 232
ASP A 323
PRO A 329
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.33A 4bz6A-5eefA:
40.4		 4bz6A-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		6 / 10 HIS A 193
HIS A 232
ASP A 323
PRO A 329
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.18A 4bz6A-5eefA:
40.4		 4bz6A-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.29A 4bz6A-5eefA:
40.4
4bz6B-5eefA:
40.5		 4bz6A-5eefA:
27.59
4bz6B-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		8 / 12 HIS A 192
HIS A 193
ASP A 230
HIS A 232
ASP A 323
PRO A 329
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.33A 4bz6A-5eefA:
40.4
4bz6B-5eefA:
40.5		 4bz6A-5eefA:
27.59
4bz6B-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		6 / 12 HIS A 193
HIS A 232
ASP A 323
PRO A 329
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.15A 4bz6A-5eefA:
40.4
4bz6B-5eefA:
40.5		 4bz6A-5eefA:
27.59
4bz6B-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.30A 4bz6C-5eefA:
40.5		 4bz6C-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		9 / 12 HIS A 192
HIS A 193
GLY A 201
ASP A 230
HIS A 232
ASP A 323
PRO A 329
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.44A 4bz6C-5eefA:
40.5		 4bz6C-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		6 / 12 HIS A 193
HIS A 232
ASP A 323
PRO A 329
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.18A 4bz6C-5eefA:
40.5		 4bz6C-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 10 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.29A 4bz6D-5eefA:
40.7		 4bz6D-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		8 / 10 HIS A 192
HIS A 193
ASP A 230
HIS A 232
ASP A 323
PRO A 329
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.36A 4bz6D-5eefA:
40.7		 4bz6D-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 10 HIS A 192
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.22A 4bz6D-5eefA:
40.7		 4bz6D-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		6 / 10 HIS A 193
HIS A 232
ASP A 323
PRO A 329
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.19A 4bz6D-5eefA:
40.7		 4bz6D-5eefA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5eef HDAC6
(Danio
rerio) 		5 / 12 LEU A 171
LEU A 180
MET A 376
ILE A 186
LEU A 357
 None
 1.16A 4j24A-5eefA:
undetectable		 4j24A-5eefA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5eef HDAC6
(Danio
rerio) 		5 / 12 LEU A 171
LEU A 180
MET A 376
ILE A 186
LEU A 357
 None
 1.15A 4j24B-5eefA:
undetectable		 4j24B-5eefA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		6 / 12 ASP A 149
HIS A 192
HIS A 193
GLY A 201
ASP A 230
HIS A 232
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
 1.31A 4lxzA-5eefA:
43.5		 4lxzA-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A  82
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 None
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.15A 4lxzA-5eefA:
43.5		 4lxzA-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		11 / 12 HIS A  82
PRO A  83
HIS A 192
HIS A 193
GLY A 201
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 None
None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.55A 4lxzA-5eefA:
43.5		 4lxzA-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.02A 4lxzA-5eefA:
43.5		 4lxzA-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		5 / 12 PRO A  83
HIS A 192
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 1.03A 4lxzA-5eefA:
43.5		 4lxzA-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		5 / 11 ASP A 149
HIS A 192
HIS A 193
ASP A 230
HIS A 232
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
 1.06A 4lxzB-5eefA:
43.5		 4lxzB-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		6 / 11 HIS A  82
HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.07A 4lxzB-5eefA:
43.5		 4lxzB-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		10 / 11 HIS A  82
PRO A  83
HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 None
None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.54A 4lxzB-5eefA:
43.5		 4lxzB-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		6 / 11 HIS A  82
PRO A  83
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 None
None
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.12A 4lxzB-5eefA:
43.5		 4lxzB-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		5 / 11 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.37A 4lxzB-5eefA:
43.5		 4lxzB-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		6 / 12 ASP A 149
HIS A 192
HIS A 193
GLY A 201
ASP A 230
HIS A 232
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
 1.27A 4lxzC-5eefA:
43.4		 4lxzC-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		10 / 12 PRO A  83
HIS A 192
HIS A 193
GLY A 201
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 None
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.48A 4lxzC-5eefA:
43.4		 4lxzC-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		6 / 12 PRO A  83
HIS A 192
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 1.16A 4lxzC-5eefA:
43.4		 4lxzC-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5eef HDAC6
(Danio
rerio) 		5 / 12 PRO A  83
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 None
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.12A 4lxzC-5eefA:
43.4		 4lxzC-5eefA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5eef HDAC6
(Danio
rerio) 		5 / 11 VAL A 325
ILE A 342
LEU A 347
ALA A 374
SER A 375
 None
 1.28A 4m83A-5eefA:
undetectable		 4m83A-5eefA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		9 / 12 HIS A 192
HIS A 193
GLY A 201
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.51A 4qa0A-5eefA:
42.0		 4qa0A-5eefA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.22A 4qa0A-5eefA:
42.0		 4qa0A-5eefA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.92A 4qa0A-5eefA:
42.0		 4qa0A-5eefA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 11 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.31A 4qa0B-5eefA:
41.9		 4qa0B-5eefA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		8 / 11 HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.53A 4qa0B-5eefA:
41.9		 4qa0B-5eefA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 11 HIS A 192
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.22A 4qa0B-5eefA:
41.9		 4qa0B-5eefA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 11 HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.93A 4qa0B-5eefA:
41.9		 4qa0B-5eefA:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.30A 4qa2A-5eefA:
41.8		 4qa2A-5eefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		9 / 12 HIS A 192
HIS A 193
GLY A 201
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.41A 4qa2A-5eefA:
41.8		 4qa2A-5eefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.22A 4qa2A-5eefA:
41.8		 4qa2A-5eefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.94A 4qa2A-5eefA:
41.8		 4qa2A-5eefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 193
ASP A 230
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 ( 2.7A)
None
 1.29A 4qa2B-5eefA:
42.3		 4qa2B-5eefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		9 / 12 HIS A 192
HIS A 193
GLY A 201
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.40A 4qa2B-5eefA:
42.3		 4qa2B-5eefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 192
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.22A 4qa2B-5eefA:
42.3		 4qa2B-5eefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5eef HDAC6
(Danio
rerio) 		5 / 12 HIS A 193
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.93A 4qa2B-5eefA:
42.3		 4qa2B-5eefA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5eef HDAC6
(Danio
rerio) 		4 / 8 PHE A 241
SER A 246
ALA A 215
PHE A 158
 None
 1.00A 4rkuA-5eefA:
undetectable
4rkuJ-5eefA:
undetectable		 4rkuA-5eefA:
19.61
4rkuJ-5eefA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5eef HDAC6
(Danio
rerio) 		3 / 3 MET A 136
GLU A 140
LEU A 144
 None
 0.70A 4v2oB-5eefA:
undetectable		 4v2oB-5eefA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5eef HDAC6
(Danio
rerio) 		5 / 9 VAL A 224
VAL A 247
PHE A 241
ILE A 237
LEU A 317
 None
 1.13A 5e4dA-5eefA:
undetectable		 5e4dA-5eefA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5eef HDAC6
(Danio
rerio) 		5 / 11 VAL A 224
VAL A 247
PHE A 241
ILE A 237
LEU A 317
 None
 1.11A 5e4dB-5eefA:
undetectable		 5e4dB-5eefA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 12 PRO A  83
HIS A 192
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 1.03A 5eeiA-5eefA:
60.5		 5eeiA-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		10 / 12 PRO A  83
SER A 150
HIS A 192
HIS A 193
GLY A 201
PHE A 202
ASP A 230
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.6A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.42A 5eeiA-5eefA:
60.5		 5eeiA-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 12 PRO A  83
HIS A 192
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 1.02A 5eeiB-5eefA:
61.1		 5eeiB-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		10 / 12 PRO A  83
SER A 150
HIS A 192
HIS A 193
GLY A 201
PHE A 202
ASP A 230
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.6A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.43A 5eeiB-5eefA:
61.1		 5eeiB-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		11 / 12 HIS A  82
PRO A  83
SER A 150
HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
GLY A 361
TYR A 363
 None
None
TSN  A2002 (-3.6A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 ( 3.8A)
TSN  A2002 (-4.3A)
 0.49A 5eenA-5eefA:
61.0		 5eenA-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		6 / 12 HIS A  82
SER A 150
HIS A 232
ASP A 323
GLY A 362
TYR A 363
 None
TSN  A2002 (-3.6A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
TSN  A2002 (-4.3A)
 1.27A 5eenA-5eefA:
61.0		 5eenA-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		6 / 12 HIS A 192
HIS A 193
ASP A 230
HIS A 232
ASP A 323
GLY A 321
 TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
None
 1.17A 5eenA-5eefA:
61.0		 5eenA-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 12 PRO A  83
HIS A 192
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.99A 5eenA-5eefA:
61.0		 5eenA-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		10 / 12 HIS A  82
PRO A  83
SER A 150
HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
TYR A 363
 None
None
TSN  A2002 (-3.6A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.50A 5eenB-5eefA:
28.2		 5eenB-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 12 PRO A  83
HIS A 192
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 1.00A 5eenB-5eefA:
28.2		 5eenB-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		10 / 12 HIS A  82
PRO A  83
SER A 150
HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
TYR A 363
 None
None
TSN  A2002 (-3.6A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.47A 5ef8A-5eefA:
61.1		 5ef8A-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 12 PRO A  83
HIS A 192
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 1.04A 5ef8A-5eefA:
61.1		 5ef8A-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		5 / 12 PRO A  83
HIS A 192
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.9A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.98A 5ef8B-5eefA:
61.2		 5ef8B-5eefA:
47.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 5eef HDAC6
(Danio
rerio) 		9 / 12 PRO A  83
SER A 150
HIS A 192
HIS A 193
PHE A 202
ASP A 230
HIS A 232
ASP A 323
TYR A 363
 None
TSN  A2002 (-3.6A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
TSN  A2002 (-3.9A)
ZN  A2001 (-2.3A)
ZN  A2001 (-3.1A)
ZN  A2001 ( 2.7A)
TSN  A2002 (-4.3A)
 0.42A 5ef8B-5eefA:
61.2		 5ef8B-5eefA:
47.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5eef HDAC6
(Danio
rerio) 		5 / 6 TRP A 229
GLY A 371
THR A 368
SER A 375
VAL A 372
 None
 1.39A 5ewuB-5eefA:
2.9		 5ewuB-5eefA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5eef HDAC6
(Danio
rerio) 		4 / 7 GLY A 191
PHE A 205
SER A 164
ASN A 200
 None
 0.83A 5n5dB-5eefA:
4.4		 5n5dB-5eefA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5eef HDAC6
(Danio
rerio) 		4 / 6 GLN A 366
MET A  93
ASN A 364
LEU A  96
 None
 1.31A 5xdhA-5eefA:
undetectable
5xdhC-5eefA:
undetectable		 5xdhA-5eefA:
11.33
5xdhC-5eefA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5eef HDAC6
(Danio
rerio) 		3 / 3 LYS A 288
ASN A 287
SER A 400
 None
 1.13A 5yw0A-5eefA:
undetectable		 5yw0A-5eefA:
22.83