SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ees'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		3 / 3 ALA A  84
VAL A  89
TRP A  92
 None
 0.88A 1av2C-5eesA:
undetectable
1av2D-5eesA:
undetectable		 1av2C-5eesA:
4.10
1av2D-5eesA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 11 PHE A 107
LEU A  64
VAL A  89
PHE A  81
VAL A  60
 None
 1.31A 1q23J-5eesA:
undetectable		 1q23J-5eesA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 11 PHE A 107
LEU A  64
VAL A  89
PHE A  81
VAL A  60
 None
 1.30A 1q23L-5eesA:
undetectable		 1q23L-5eesA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 10 LEU A 102
LEU A 242
ALA A 104
LEU A 113
VAL A 112
 None
 1.24A 2bxeA-5eesA:
undetectable		 2bxeA-5eesA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 8 CYH A  67
THR A  55
THR A  78
VAL A  89
 None
NAP  A 302 (-4.4A)
NAP  A 302 ( 4.1A)
None
 1.04A 2fb2A-5eesA:
undetectable		 2fb2A-5eesA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 8 ILE A 184
ALA A 128
PHE A 202
ALA A 121
 None
 0.94A 3hrdA-5eesA:
undetectable
3hrdB-5eesA:
undetectable		 3hrdA-5eesA:
21.85
3hrdB-5eesA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 11 ALA A 222
VAL A  22
GLY A 228
VAL A   7
ILE A  18
 None
 1.02A 3lzvB-5eesA:
undetectable		 3lzvB-5eesA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 10 ALA A 222
VAL A  22
GLY A 228
VAL A   7
ILE A  18
 None
 1.01A 3nujA-5eesA:
undetectable		 3nujA-5eesA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A   9
THR A  56
ASN A  63
VAL A  19
GLY A  35
 NAP  A 302 (-3.5A)
NAP  A 302 ( 4.2A)
NAP  A 302 ( 3.7A)
None
NAP  A 302 (-3.8A)
 0.87A 3sglA-5eesA:
3.0		 3sglA-5eesA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 9 VAL A  52
VAL A  51
VAL A  22
ILE A  18
GLY A   9
 None
None
None
None
NAP  A 302 (-3.5A)
 1.16A 4fwdA-5eesA:
undetectable		 4fwdA-5eesA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		4 / 4 ILE A   3
VAL A  51
VAL A 229
ARG A 230
 None
 1.32A 4m6tA-5eesA:
undetectable		 4m6tA-5eesA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 12 SER A  25
VAL A  50
ASP A  27
ILE A   3
GLY A   2
 None
 0.86A 4y8wA-5eesA:
undetectable		 4y8wA-5eesA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5ees 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE
(Corynebacterium
glutamicum) 		5 / 12 SER A  25
VAL A  50
ASP A  27
ILE A   3
GLY A   2
 None
 0.84A 4y8wB-5eesA:
undetectable		 4y8wB-5eesA:
17.49