SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5efr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 6 PHE A 419
THR A 413
LEU A 459
VAL A 448
 None
 1.05A 2feuA-5efrA:
undetectable		 2feuA-5efrA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		5 / 12 ARG A1145
ILE A1103
ALA A1071
ARG A1114
GLU A1111
 None
 1.19A 2j0dA-5efrA:
undetectable		 2j0dA-5efrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 4 ALA A1041
TYR A1045
ALA A1073
TYR A1076
 None
 1.18A 2wlkA-5efrA:
undetectable
2wlkB-5efrA:
undetectable		 2wlkA-5efrA:
19.53
2wlkB-5efrA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 7 PHE A 419
THR A 413
LEU A 459
VAL A 448
 None
 1.04A 3fwfB-5efrA:
undetectable		 3fwfB-5efrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 5 TYR A1101
GLN A1074
ILE A1054
LEU A1077
 None
 1.06A 3ls4L-5efrA:
undetectable		 3ls4L-5efrA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 8 ILE A1098
GLU A1111
TYR A1146
PHE A1142
 None
 1.03A 3rqwI-5efrA:
2.4
3rqwJ-5efrA:
1.6		 3rqwI-5efrA:
18.57
3rqwJ-5efrA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 5 ARG A 408
TYR A1177
THR A 393
PRO A 415
 None
 1.44A 4mjqA-5efrA:
undetectable		 4mjqA-5efrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA407_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 5 ASP A1153
THR A1156
GLN A1157
ARG A1160
 None
 0.86A 5k9dA-5efrA:
undetectable		 5k9dA-5efrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1S_B_SAMB604_0
(RADICAL SAM)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		5 / 9 LEU A 325
THR A 368
VAL A 383
TYR A 355
SER A 352
 None
 1.47A 5v1sB-5efrA:
0.0		 5v1sB-5efrA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 7 PHE A 419
THR A 413
LEU A 459
VAL A 448
 None
 1.05A 5wk9A-5efrA:
undetectable		 5wk9A-5efrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5efr BAMA-BAMD FUSION
PROTEIN
(Rhodothermus
marinus) 		4 / 7 ARG A1212
TYR A1171
LEU A1176
TYR A1190
 None
 1.38A 6g2pA-5efrA:
undetectable		 6g2pA-5efrA:
20.30