SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eft'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		5 / 11 ILE B 230
LEU B 196
ALA B  88
ILE B  60
VAL B 195
 None
 1.10A 2fxdA-5eftB:
undetectable		 2fxdA-5eftB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		4 / 7 LEU B  56
PHE B 121
ILE B  52
PHE B 199
 None
 0.81A 2opxA-5eftB:
undetectable		 2opxA-5eftB:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		5 / 9 PHE B 288
GLU B 285
GLY B 308
GLU B 280
ILE B 278
 None
 1.18A 2w98A-5eftB:
undetectable		 2w98A-5eftB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		4 / 8 PHE B 203
LEU B 253
PHE B 261
LEU B 264
 None
 0.92A 3i45A-5eftB:
undetectable		 3i45A-5eftB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		4 / 6 ILE B  14
HIS B 206
LEU B  48
ASP B 215
 None
 1.00A 3oi8A-5eftB:
undetectable		 3oi8A-5eftB:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		4 / 6 SER B 168
ASP B 120
ARG B 175
GLU B 189
 None
 1.25A 4eysA-5eftB:
undetectable		 4eysA-5eftB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		3 / 3 PHE B 199
TYR B  12
TYR B 223
 None
 1.04A 4ffwA-5eftB:
undetectable		 4ffwA-5eftB:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		5 / 12 LEU B 253
LEU B 204
LEU B 207
ILE B  52
PHE B 261
 None
 1.01A 4odrA-5eftB:
undetectable
4odrB-5eftB:
undetectable		 4odrA-5eftB:
16.47
4odrB-5eftB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		5 / 11 LEU B 253
LEU B 204
LEU B 207
ILE B  52
PHE B 261
 None
 1.07A 4odrA-5eftB:
undetectable
4odrB-5eftB:
undetectable		 4odrA-5eftB:
16.47
4odrB-5eftB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		5 / 12 GLY B 208
ASN B 212
ILE B  14
VAL B 220
THR B   8
 None
 0.94A 4q5mA-5eftB:
undetectable		 4q5mA-5eftB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		4 / 7 LEU B 264
ARG B 265
LEU B 268
LEU B 253
 None
 0.79A 4wg0L-5eftB:
undetectable
4wg0M-5eftB:
undetectable		 4wg0L-5eftB:
7.91
4wg0M-5eftB:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5eft P9-1
(Southern
rice
black-streaked
dwarf
virus) 		5 / 12 ILE B 249
GLU B 221
LEU B  55
GLY B  51
TYR B  12
 None
 0.92A 5igtA-5eftB:
0.7		 5igtA-5eftB:
20.58