SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5efx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5efx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 2
(Homo
sapiens) 		5 / 9 THR A 553
LEU A 479
VAL A 493
GLY A 477
VAL A 565
 None
 1.32A 1dz8B-5efxA:
undetectable		 1dz8B-5efxA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 5efx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 2
(Homo
sapiens) 		5 / 9 GLY A 464
GLU A 467
PHE A 579
LEU A 503
ILE A 445
 None
 1.47A 1oltA-5efxA:
undetectable		 1oltA-5efxA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5efx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 2
(Homo
sapiens) 		5 / 12 LEU A 442
MET A 449
PHE A 463
LEU A 581
LEU A 523
 None
 1.50A 4o8fB-5efxA:
undetectable		 4o8fB-5efxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5efx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 2
(Homo
sapiens) 		4 / 6 GLY A 464
GLU A 467
TYR A 446
ILE A 445
 None
 0.95A 5kmfA-5efxA:
undetectable
5kmfC-5efxA:
undetectable		 5kmfA-5efxA:
17.20
5kmfC-5efxA:
17.20