SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5eg6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 12 PHE C 437
PRO C 432
LEU C  66
ASP C 414
MET C  62
 None
 1.41A 1e7wA-5eg6C:
undetectable		 1e7wA-5eg6C:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 9 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 1.12A 1hpvB-5eg6C:
undetectable		 1hpvB-5eg6C:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 11 SER C 426
CYH C 429
LEU C 399
THR C 400
VAL C 430
 None
 1.09A 1pkvA-5eg6C:
2.7
1pkvB-5eg6C:
undetectable		 1pkvA-5eg6C:
13.40
1pkvB-5eg6C:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 12 LEU C 205
ALA C 245
ALA C 214
VAL C  81
LEU C 309
 None
EDO  C 502 ( 3.7A)
None
None
None
 1.14A 1rbpA-5eg6C:
undetectable		 1rbpA-5eg6C:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		4 / 4 ALA C 362
VAL C  99
PHE C 182
THR C  73
 None
 1.48A 2pkkA-5eg6C:
undetectable		 2pkkA-5eg6C:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 11 LEU C 288
PHE C 314
LEU C 285
VAL C 231
VAL C 213
 None
 1.36A 2po5B-5eg6C:
undetectable		 2po5B-5eg6C:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 9 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 1.08A 2q5kA-5eg6C:
undetectable		 2q5kA-5eg6C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 12 ILE C 356
THR C 359
VAL C 306
ILE C 268
ILE C 248
 None
EDO  C 502 (-3.8A)
None
None
None
 1.20A 2yzqA-5eg6C:
undetectable		 2yzqA-5eg6C:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 9 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 1.05A 3ektB-5eg6C:
undetectable		 3ektB-5eg6C:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 9 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 1.04A 3ekvB-5eg6C:
undetectable		 3ekvB-5eg6C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 9 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 1.05A 3el0B-5eg6C:
undetectable		 3el0B-5eg6C:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 10 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 1.02A 3nujA-5eg6C:
undetectable		 3nujA-5eg6C:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 12 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 0.96A 3pwmA-5eg6C:
undetectable		 3pwmA-5eg6C:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 12 LEU C 288
PHE C 314
LEU C 285
ILE C 268
VAL C 231
 None
 1.39A 3w1wB-5eg6C:
undetectable		 3w1wB-5eg6C:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 12 LEU C 288
PHE C 314
LEU C 285
VAL C 231
VAL C 213
 None
 1.35A 3w1wB-5eg6C:
undetectable		 3w1wB-5eg6C:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 10 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 0.99A 4dqcA-5eg6C:
undetectable		 4dqcA-5eg6C:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 11 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 0.99A 4dqhA-5eg6C:
undetectable		 4dqhA-5eg6C:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		4 / 8 MET C 171
ILE C  76
PRO C 376
VAL C 380
 None
None
None
EDO  C 510 (-3.9A)
 1.21A 4f4dB-5eg6C:
undetectable		 4f4dB-5eg6C:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		4 / 7 ILE C 290
TYR C 270
PRO C 305
HIS C 310
 None
 1.18A 4g5jA-5eg6C:
undetectable		 4g5jA-5eg6C:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 10 VAL C  99
GLY C 130
ILE C 131
PRO C  97
ILE C  76
 None
None
BU1  C 521 (-4.7A)
None
None
 1.06A 4q1wB-5eg6C:
undetectable		 4q1wB-5eg6C:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		5 / 10 ARG C 291
ILE C 348
ALA C 298
LEU C 299
ALA C 302
 None
 1.14A 4xk8B-5eg6C:
undetectable		 4xk8B-5eg6C:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		3 / 3 LYS C 185
ARG C 186
HIS C 164
 None
 1.19A 4zbrA-5eg6C:
undetectable		 4zbrA-5eg6C:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5eg6 RECOMBINING BINDING
PROTEIN SUPPRESSOR
OF HAIRLESS
(Mus
musculus) 		3 / 3 LEU C 316
GLN C 333
LYS C 275
 None
 0.96A 6exiA-5eg6C:
undetectable		 6exiA-5eg6C:
10.22