SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ege'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 8 ASP A 193
ASP A  32
TYR A  38
ARG A  35
 ZN  A 508 (-2.1A)
ZN  A 509 (-1.9A)
None
None
 1.29A 1ceaA-5egeA:
undetectable
1ceaB-5egeA:
undetectable		 1ceaA-5egeA:
12.31
1ceaB-5egeA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 7 ASP A 193
ASP A  32
TYR A  38
ARG A  35
 ZN  A 508 (-2.1A)
ZN  A 509 (-1.9A)
None
None
 1.32A 1ceaB-5egeA:
undetectable		 1ceaB-5egeA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 7 ASP A 193
ASP A  32
TYR A  38
ARG A  35
 ZN  A 508 (-2.1A)
ZN  A 509 (-1.9A)
None
None
 1.32A 1cebA-5egeA:
undetectable		 1cebA-5egeA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 7 ASP A 193
ASP A  32
TYR A  38
ARG A  35
 ZN  A 508 (-2.1A)
ZN  A 509 (-1.9A)
None
None
 1.30A 1cebB-5egeA:
undetectable		 1cebB-5egeA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 5 ASP A 193
HIS A 197
HIS A 241
HIS A 354
 ZN  A 508 (-2.1A)
ZN  A 508 ( 3.2A)
ZN  A 509 (-3.4A)
ZN  A 508 (-3.3A)
 0.45A 1ei6A-5egeA:
30.0		 1ei6A-5egeA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 8 ASP A  32
ASP A 193
HIS A 197
HIS A 241
HIS A 354
 ZN  A 509 (-1.9A)
ZN  A 508 (-2.1A)
ZN  A 508 ( 3.2A)
ZN  A 509 (-3.4A)
ZN  A 508 (-3.3A)
 0.51A 1ei6C-5egeA:
30.0		 1ei6C-5egeA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		3 / 3 TRP A 353
PHE A 328
TRP A 248
 None
 1.42A 1r15C-5egeA:
undetectable		 1r15C-5egeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		3 / 3 TRP A 353
PHE A 328
TRP A 248
 None
 1.42A 1r15F-5egeA:
undetectable		 1r15F-5egeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		3 / 3 TRP A 353
PHE A 328
TRP A 248
 None
 1.42A 1r15G-5egeA:
undetectable		 1r15G-5egeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		3 / 3 TRP A 353
PHE A 328
TRP A 248
 None
 1.41A 1r15H-5egeA:
undetectable		 1r15H-5egeA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 224
LEU A  27
TYR A 137
VAL A 170
ALA A 169
 None
 1.15A 1tlsA-5egeA:
undetectable		 1tlsA-5egeA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.94A 1xzxX-5egeA:
undetectable		 1xzxX-5egeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.96A 1y0xX-5egeA:
undetectable		 1y0xX-5egeA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 11 GLU A 254
ALA A 330
GLU A 331
ASP A 269
PHE A 328
 None
 1.24A 2admA-5egeA:
undetectable		 2admA-5egeA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 11 GLU A 254
ALA A 330
GLU A 331
ASP A 269
PHE A 328
 None
 1.19A 2admB-5egeA:
undetectable		 2admB-5egeA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		3 / 3 THR A 126
PRO A 400
TYR A 389
 None
 0.70A 2dxrA-5egeA:
undetectable		 2dxrA-5egeA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 7 TYR A 188
GLY A  33
TYR A  75
ASP A 245
 None
 0.97A 2g72B-5egeA:
undetectable		 2g72B-5egeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.91A 2h77A-5egeA:
undetectable		 2h77A-5egeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.96A 2h79A-5egeA:
undetectable		 2h79A-5egeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 8 TYR A 356
TYR A  38
HIS A 197
GLY A 196
 None
None
ZN  A 508 ( 3.2A)
None
 1.10A 2ha4A-5egeA:
undetectable		 2ha4A-5egeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.94A 3gwsX-5egeA:
undetectable		 3gwsX-5egeA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 11 ALA A 393
ILE A 398
GLY A 397
LEU A 123
LEU A 184
 None
 1.02A 3kw2A-5egeA:
undetectable		 3kw2A-5egeA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 11 ALA A 393
ILE A 398
GLY A 397
LEU A 123
LEU A 184
 None
 1.04A 3kw2B-5egeA:
undetectable		 3kw2B-5egeA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		6 / 11 ILE A 236
SER A 412
PHE A 374
ILE A 383
VAL A 388
VAL A 410
 None
 1.40A 3kw4A-5egeA:
undetectable		 3kw4A-5egeA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 6 SER A 317
ILE A  90
TYR A 310
ASP A 357
 None
 1.07A 3q70A-5egeA:
undetectable		 3q70A-5egeA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 6 ALA A 173
ILE A 187
LEU A  27
ALA A 182
 None
 0.86A 3r9sC-5egeA:
undetectable		 3r9sC-5egeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 4 VAL A 213
PHE A  34
PHE A 238
VAL A  28
 None
 1.03A 3rv5C-5egeA:
undetectable
3rv5D-5egeA:
undetectable		 3rv5C-5egeA:
11.42
3rv5D-5egeA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.79A 3uvvA-5egeA:
undetectable		 3uvvA-5egeA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 8 GLN A 265
TRP A 277
ASN A 100
THR A  99
 None
None
NAG  A 501 (-1.9A)
None
 1.21A 4d1yA-5egeA:
undetectable
4d1yB-5egeA:
undetectable		 4d1yA-5egeA:
18.62
4d1yB-5egeA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 6 TYR A  75
HIS A 354
HIS A 197
TYR A 157
 None
ZN  A 508 (-3.3A)
ZN  A 508 ( 3.2A)
None
 1.45A 4df2A-5egeA:
undetectable		 4df2A-5egeA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		3 / 3 ARG A 346
TRP A 339
GLY A 348
 None
FUL  A 505 ( 4.4A)
NAG  A 503 ( 3.8A)
 1.02A 4e7cA-5egeA:
undetectable		 4e7cA-5egeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ASP A 193
TYR A  75
LEU A  78
TYR A 188
HIS A 354
 ZN  A 508 (-2.1A)
None
None
None
ZN  A 508 (-3.3A)
 1.28A 4j03A-5egeA:
undetectable		 4j03A-5egeA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 6 GLY A 355
ASP A  66
PRO A  73
HIS A  87
 None
 0.78A 4lajA-5egeA:
undetectable
4lajB-5egeA:
undetectable		 4lajA-5egeA:
21.55
4lajB-5egeA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.99A 4lnwA-5egeA:
undetectable		 4lnwA-5egeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 ILE A 187
ALA A 173
MET A 220
LEU A 237
PHE A 166
 None
 0.96A 4lnxA-5egeA:
undetectable		 4lnxA-5egeA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 12 HIS A 354
HIS A 197
GLY A 196
ASP A  32
GLY A  33
 ZN  A 508 (-3.3A)
ZN  A 508 ( 3.2A)
None
ZN  A 509 (-1.9A)
None
 1.23A 4lxzC-5egeA:
2.9		 4lxzC-5egeA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		3 / 3 PRO A 318
LEU A 319
HIS A 288
 None
 0.49A 4pevA-5egeA:
undetectable		 4pevA-5egeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 8 GLY A 242
SER A 239
SER A  71
HIS A 354
 None
None
ZN  A 509 (-2.0A)
ZN  A 508 (-3.3A)
 1.03A 4wryA-5egeA:
undetectable		 4wryA-5egeA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 8 GLY A 242
SER A 239
SER A  71
HIS A 354
 None
None
ZN  A 509 (-2.0A)
ZN  A 508 (-3.3A)
 1.01A 4wrzA-5egeA:
undetectable		 4wrzA-5egeA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		4 / 8 GLY A 242
SER A 239
SER A  71
HIS A 354
 None
None
ZN  A 509 (-2.0A)
ZN  A 508 (-3.3A)
 0.94A 4ws1A-5egeA:
undetectable		 4ws1A-5egeA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 10 ASP A  32
SER A  71
HIS A 241
TYR A  75
GLU A 143
 ZN  A 509 (-1.9A)
ZN  A 509 (-2.0A)
ZN  A 509 (-3.4A)
None
None
 1.35A 6cggB-5egeA:
0.4		 6cggB-5egeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_B_84GB600_0
(BIFUNCTIONAL AAC/APH)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 10 ASP A 240
SER A  71
HIS A 241
TYR A  75
GLU A 143
 ZN  A 509 (-2.4A)
ZN  A 509 (-2.0A)
ZN  A 509 (-3.4A)
None
None
 1.46A 6cggB-5egeA:
0.4		 6cggB-5egeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 11 ASP A  32
SER A  71
HIS A 241
TYR A  75
GLU A 143
 ZN  A 509 (-1.9A)
ZN  A 509 (-2.0A)
ZN  A 509 (-3.4A)
None
None
 1.35A 6cggD-5egeA:
0.3		 6cggD-5egeA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 5ege ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 6
(Mus
musculus) 		5 / 11 ASP A 240
SER A  71
HIS A 241
TYR A  75
GLU A 143
 ZN  A 509 (-2.4A)
ZN  A 509 (-2.0A)
ZN  A 509 (-3.4A)
None
None
 1.41A 6cggD-5egeA:
0.3		 6cggD-5egeA:
20.18