SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5egn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 7 GLY A  33
TRP A  35
ASP A  52
TYR A  12
 None
 1.04A 1th6A-5egnA:
undetectable		 1th6A-5egnA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 6 THR A  30
GLN A 245
HIS A 242
ASN A  92
 None
 1.45A 1tt0A-5egnA:
1.0		 1tt0A-5egnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 6 THR A  30
GLN A 245
HIS A 242
ASN A  92
 None
 1.42A 1tt0B-5egnA:
undetectable		 1tt0B-5egnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 6 THR A  30
GLN A 245
HIS A 242
ASN A  92
 None
 1.42A 1tt0C-5egnA:
undetectable		 1tt0C-5egnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 6 THR A  30
GLN A 245
HIS A 242
ASN A  92
 None
 1.43A 1tt0D-5egnA:
undetectable		 1tt0D-5egnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 10 ASP A  52
TRP A  35
GLY A  96
GLY A  95
SER A  93
 None
 1.28A 1w76B-5egnA:
7.2		 1w76B-5egnA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 10 THR A 206
GLU A 233
GLY A 231
LEU A 234
ALA A 226
 None
 0.98A 1x7pA-5egnA:
undetectable
1x7pB-5egnA:
2.1		 1x7pA-5egnA:
21.85
1x7pB-5egnA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 5 ILE A  34
ILE A 237
ILE A 161
MET A 165
LEU A 114
 None
 1.32A 1zgyA-5egnA:
undetectable		 1zgyA-5egnA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 7 GLY A  33
TRP A  35
ASP A  52
TYR A  12
 None
 1.04A 2armA-5egnA:
undetectable		 2armA-5egnA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 12 LEU A 199
GLY A  96
ASN A  92
LEU A 122
PHE A 191
 None
 1.03A 2zzmA-5egnA:
undetectable		 2zzmA-5egnA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 12 VAL A  75
LEU A  79
GLY A  96
ALA A  99
LEU A 102
 None
 1.08A 3nt1A-5egnA:
undetectable		 3nt1A-5egnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 12 VAL A  75
LEU A  79
GLY A  96
ALA A  99
LEU A 102
 None
 1.07A 3nt1B-5egnA:
undetectable		 3nt1B-5egnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 7 ASN A 113
ALA A  99
ARG A 109
ALA A  87
 None
 1.05A 3twpA-5egnA:
undetectable		 3twpA-5egnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 7 ASN A 113
ALA A  99
ARG A 109
ALA A  87
 None
 0.89A 3twpB-5egnA:
undetectable		 3twpB-5egnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 7 ASN A 113
ALA A  99
ARG A 109
ALA A  87
 None
 1.11A 3twpC-5egnA:
undetectable		 3twpC-5egnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 5egn ESTERASE
(uncultured
bacterium) 		3 / 3 ASP A  52
GLY A  33
TYR A  12
 None
 0.79A 3w9tC-5egnA:
undetectable		 3w9tC-5egnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 5egn ESTERASE
(uncultured
bacterium) 		3 / 3 ASP A  52
GLY A  33
TYR A  12
 None
 0.78A 3w9tG-5egnA:
undetectable		 3w9tG-5egnA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 11 VAL A  75
ALA A  72
GLY A  91
ILE A  49
PHE A  42
 None
 1.06A 3zosA-5egnA:
undetectable
3zosB-5egnA:
undetectable		 3zosA-5egnA:
22.51
3zosB-5egnA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5egn ESTERASE
(uncultured
bacterium) 		5 / 11 HIS A 168
PHE A 243
ILE A  34
GLY A  95
GLY A  91
 None
 1.21A 4fglA-5egnA:
3.7
4fglB-5egnA:
3.8		 4fglA-5egnA:
23.78
4fglB-5egnA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 5 TYR A  12
ILE A  11
ASN A  31
ILE A  51
 None
 1.07A 4jtpA-5egnA:
undetectable		 4jtpA-5egnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 10 VAL A  75
LEU A  79
GLY A  96
ALA A  99
LEU A 102
 None
 1.09A 4ph9A-5egnA:
undetectable		 4ph9A-5egnA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 10 VAL A  75
LEU A  79
GLY A  96
ALA A  99
LEU A 102
 None
 1.07A 4ph9B-5egnA:
undetectable		 4ph9B-5egnA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 9 VAL A  75
LEU A  79
GLY A  96
ALA A  99
LEU A 102
 None
 1.04A 4rs0A-5egnA:
undetectable		 4rs0A-5egnA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 8 PHE A 142
ALA A 149
LEU A 146
GLY A 143
 None
 1.00A 4xk8a-5egnA:
undetectable		 4xk8a-5egnA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5egn ESTERASE
(uncultured
bacterium) 		4 / 5 VAL A 209
VAL A  90
GLY A  91
PHE A 252
 None
 1.11A 5d4nA-5egnA:
undetectable
5d4nC-5egnA:
undetectable		 5d4nA-5egnA:
20.16
5d4nC-5egnA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5egn ESTERASE
(uncultured
bacterium) 		5 / 9 ASP A  74
ILE A  51
GLY A  32
ILE A  34
ILE A  98
 None
 1.16A 5kr0A-5egnA:
undetectable		 5kr0A-5egnA:
20.61