SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5egw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		3 / 3 TRP A 137
ALA A 163
VAL A 294
 None
 0.95A 1c4dA-5egwA:
undetectable
1c4dB-5egwA:
undetectable		 1c4dA-5egwA:
2.86
1c4dB-5egwA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		5 / 11 ASN A  58
GLY A  38
PHE A  60
GLY A  35
PHE A  57
 None
 1.34A 1ho5A-5egwA:
undetectable		 1ho5A-5egwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		5 / 10 ASN A  58
GLY A  38
PHE A  60
GLY A  35
PHE A  57
 None
 1.33A 1ho5B-5egwA:
undetectable		 1ho5B-5egwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		5 / 12 GLY A 332
ALA A 337
VAL A 243
GLY A 263
VAL A 255
 None
 1.08A 1hsgB-5egwA:
undetectable		 1hsgB-5egwA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		4 / 6 ASN A 190
ARG A 108
ILE A 101
GLY A 196
 None
 0.96A 1oniA-5egwA:
undetectable
1oniB-5egwA:
undetectable		 1oniA-5egwA:
16.53
1oniB-5egwA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		4 / 6 ASN A 190
ARG A 108
ILE A 101
GLY A 196
 None
 0.98A 1oniD-5egwA:
undetectable
1oniF-5egwA:
undetectable		 1oniD-5egwA:
16.53
1oniF-5egwA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		4 / 7 ILE A 101
GLY A 196
ASN A 190
ARG A 108
 None
 0.99A 1oniG-5egwA:
undetectable
1oniI-5egwA:
undetectable		 1oniG-5egwA:
16.53
1oniI-5egwA:
16.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		6 / 10 GLN A 149
GLY A 153
SER A 154
TRP A 156
PHE A 158
HIS A 289
 None
 0.41A 1stfE-5egwA:
31.7
1stfI-5egwA:
undetectable		 1stfE-5egwA:
44.30
1stfI-5egwA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		4 / 8 VAL A 135
LEU A 175
GLY A 166
ALA A 169
 None
 0.92A 2xfsA-5egwA:
undetectable		 2xfsA-5egwA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		4 / 7 GLN A 149
GLY A 153
HIS A 289
TRP A 312
 None
 0.63A 3ai8A-5egwA:
24.6		 3ai8A-5egwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		4 / 7 HIS A  26
GLU A  34
ARG A  28
GLU A  31
 None
 1.27A 3ql6A-5egwA:
undetectable		 3ql6A-5egwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		3 / 3 GLN A 258
PHE A 342
TYR A 125
 None
 0.97A 3ucjB-5egwA:
undetectable		 3ucjB-5egwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		4 / 8 SER A 216
GLU A 224
ASP A 227
ASP A 185
 None
 1.41A 4qb9D-5egwA:
undetectable		 4qb9D-5egwA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5egw CYSTEINE PROTEASE
(Ambrosia
artemisiifolia) 		5 / 12 GLY A 290
TRP A 312
LEU A 197
GLY A 195
GLY A 150
 None
 1.13A 5d4uA-5egwA:
undetectable		 5d4uA-5egwA:
19.85